Search Results - "SEEGMILLER, J. E"

Interleukin 1β Suppresses Transforming Growth Factor-Induced Inorganic Pyrophosphate (PPi) Production and Expression of the PPi- Generating Enzyme PC-1 in Human Chondrocytes by Lotz, Martin, Rosen, Fred, McCabe, Greg, Quach, Jacqueline, Blanco, Francisco, Dudler, Jean, Solan, Joell, Goding, James, Seegmiller, J. Edwin, Terkeltaub, Robert

“…Articular cartilage chondrocytes have the unique ability to elaborate large amounts of extracellular pyrophosphate (PPi), and transforming growth factor β…”
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Increased Gene Expression of Alzheimer Disease β-Amyloid Precursor Protein in Senescent Cultured Fibroblasts by Adler, Mark J., Coronel, Crystal, Shelton, Earl, Seegmiller, J. E., Dewji, Nazneen N.

“…The pathological hallmark of Alzheimer disease is the accumulation of neurofibrillary tangles and neuritic plaques in the brains of patients. Plaque cores…”
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Effects of ascorbic acid in alkaptonuria: alterations in benzoquinone acetic acid and an ontogenic effect in infancy by WOLFF, J. A, BARSHOP, B, NYHAN, W. L, LESLIE, J, SEEGMILLER, J. E, GRUBER, H, GARST, M, WINTER, S, MICHALS, K, MATALON, R

“…The effects of ascorbic acid on the excretion of homogentisic acid and its derivative benzoquinone acetic acid were studied in two adults and three infants…”
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Chondrocyte-Derived Apoptotic Bodies and Calcification of Articular Cartilage by Hashimoto, Sanshiro, Ochs, Robert L., Rosen, Fred, Quach, Jacqueline, McCabe, Greg, Solan, Joell, Seegmiller, J. Edwin, Terkeltaub, Robert, Lotz, Martin

“…Chondrocytes exposed to nitric oxide (NO) or antibody to Fas undergo cell death by apoptosis. This study examines structural and functional properties of…”
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Detection of 5'-phosphoribosyl-4-(N-succinylcarboxamide)-5-aminoimidazole in urine by use of the Bratton-Marshall reaction: identification of patients deficient in adenylosuccinate lyase activity by Laikind, P K, Seegmiller, J E, Gruber, H E

“…The Bratton-Marshall reaction can be used to identify patients with adenylosuccinate lyase deficiency. These patients excrete in their urine the…”
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Biochemical Basis for the Enhanced Toxicity of Deoxyribonucleosides toward Malignant Human T Cell Lines by Carson, Dennis A., Kaye, Jonathan, Matsumoto, Steven, Seegmiller, J. E., Thompson, Linda

“…Human malignant T cell lines have high levels of deoxyribonucleoside phosphorylating activity and low levels of deoxyribonucleotide dephosphorylating activity…”
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Lymphospecific Toxicity in Adenosine Deaminase Deficiency and Purine Nucleoside Phosphorylase Deficiency: Possible Role of Nucleoside Kinase(s) by Carson, Dennis A., Kaye, Jonathan, Seegmiller, J. E.

“…Inherited deficiencies of the enzymes adenosine deaminase (adenosine aminohydrolase; EC 3.5.4.4) and purine nucleoside phosphorylase…”
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Differential Sensitivity of Human Leukemic T Cell Lines and B Cell Lines to Growth Inhibition by Deoxyadenosine by Carson, Dennis A, Kaye, Jonathan, Seegmiller, J. E

“…Previous experiments have suggested that the lymphospecific toxicity associated with inherited deficiencies of the enzymes adenosine deaminase (ADA) (adenosine…”
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Luminescent immobilized enzyme test systems for inorganic pyrophosphate: assays using firefly luciferase and nicotinamide-mononucleotide adenylyl transferase or adenosine-5'-triphosphate sulfurylase by Barshop, B A, Adamson, D T, Vellom, D C, Rosen, F, Epstein, B L, Seegmiller, J E

“…Inorganic pyrophosphate was measured by luminescence produced by a pyrophosphatase (NAD adenylyl-transferase or ATP sulfurylase) coimmobilized with firefly…”
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Partial phenotypic correction of human Lesch-Nyhan (hypoxanthine-guanine phosphoribosyltransferase-deficient) lymphoblasts with a transmissible retroviral vector by Willis, R C, Jolly, D J, Miller, A D, Plent, M M, Esty, A C, Anderson, P J, Chang, H C, Jones, O W, Seegmiller, J E, Friedmann, T

“…A human Lesch-Nyhan (hereditary, severe hypoxanthine-guanine phosphoribosyltransferase (HPR transferase) deficiency) B-lymphoblast line was infected with an…”
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Contributions of Lesch‐Nyhan syndrome to the understanding of purine metabolism by Seegmiller, J. E.

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Adenosine Kinase Initiates the Major Route of Ribavirin Activation in a Cultured Human Cell Line by Willis, R. C., Carson, D. A., Seegmiller, J. E.

“…Inhibition of IMP dehydrogenase (EC 1.2.1.14) by ribavirin causes the normal human lymphoblast to excrete increased amounts of newly formed purine into the…”
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Effect of adenosine deaminase inhibition upon human lymphocyte blastogenesis by Carson, D A, Seegmiller, J E

“…The biochemical mechanisms by which a genetically determined deficiency of adenosine deaminase leads to immunodeficiency are still poorly understood and…”
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Adenine nucleotide degradation during energy depletion in human lymphoblasts. Adenosine accumulation and adenylate energy charge correlation by Matsumoto, S S, Raivio, K O, Seegmiller, J E

“…Adenine nucleotide breakdown to nucleosides and purine bases was measured in cultures of human lymphoblastoid cells following: 1) the inhibition of oxidative…”
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Glial Cells Metabolically Cooperate: A Potential Requirement for Gene Replacement Therapy by Gruber, H. E., Koenker, R., Luchtman, L. A., Willis, R. C., Seegmiller, J. E.

“…Immunofluorescently labeled glial cells are shown by radioautography to metabolically cooperate with hypoxanthine phosphoribosyltransferase-deficient…”
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Purine nucleotide reutilization by human lymphoblast lines with aberrations of the inosinate cycle by Willis, R C, Kaufman, A H, Seegmiller, J E

“…A purine nucleotide (inosinate) cycle is demonstrated with human lymphoblasts. The lymphoblast requires approximately 50 nmol of purine/10(6) cell increment…”
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Retroviral Vector-Mediated Gene Transfer into Human Hematopoietic Progenitor Cells by Gruber, Harry E., Finley, Kim D., Hershberg, Robert M., Katzman, Scott S., Laikind, Paul K., Seegmiller, J. Edwin, Friedmann, Theodore, Yee, Jiing-Kuan, Jolly, Douglas J.

“…The transfer of the human gene for hypoxanthine phosphoribosyltransferase (HPRT) into human bone marrow cells was accomplished by use of a retroviral vector…”
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Adenosine metabolism in phytohemagglutinin-stimulated human lymphocytes by Snyder, F F, Mendelsohn, J, Seegmiller, J E

“…The association of a human genetic deficiency of adenosine deaminase activity with combined immunodeficiency prompted a study of the effects of adenosine and…”
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Ochronosis: a report of a case and a review of literature by Konttinen, Y T, Hoikka, V, Landtman, M, Saari, H, Santavirta, S, Metsärinne, K, Seegmiller, J E

“…A patient with alkaptonuria and ochronotic pigment deposited in articular cartilage and sclerae clinically manifested a serious osteoarthritis of the…”
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Regulation of de novo purine biosynthesis in human lymphoblasts. Coordinate control of proximal (rate-determining) steps and the inosinic acid branch point by Hershfield, M S, Seegmiller, J E

“…Purine nucleotide synthesis de novo has been studied in a permanent tissue culture line of human splenic lymphoblasts with particular attention to coordination…”
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