Search Results - "SEEGER, Werner"

Hypoxia-inducible factor signaling in pulmonary hypertension by Pullamsetti, Soni Savai, Mamazhakypov, Argen, Weissmann, Norbert, Seeger, Werner, Savai, Rajkumar

“…Pulmonary hypertension (PH) is characterized by pulmonary artery remodeling that can subsequently culminate in right heart failure and premature death…”
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Pulmonary hypertension in chronic lung disease and hypoxia by Nathan, Steven D, Barbera, Joan A, Gaine, Sean P, Harari, Sergio, Martinez, Fernando J, Olschewski, Horst, Olsson, Karen M, Peacock, Andrew J, Pepke-Zaba, Joanna, Provencher, Steeve, Weissmann, Norbert, Seeger, Werner

“…Pulmonary hypertension (PH) frequently complicates the course of patients with various forms of chronic lung disease (CLD). CLD-associated PH (CLD-PH) is…”
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Senescence-associated secretory phenotype and its possible role in chronic obstructive pulmonary disease by Kumar, Manish, Seeger, Werner, Voswinckel, Robert

“…Chronic obstructive pulmonary disease (COPD) is a major disease of the lungs. It primarily occurs after a prolonged period of cigarette smoking. Chronic…”
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Validation of the Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio for the Assessment of Right Ventricular-Arterial Coupling in Severe Pulmonary Hypertension by Tello, Khodr, Wan, Jun, Dalmer, Antonia, Vanderpool, Rebecca, Ghofrani, Hossein A, Naeije, Robert, Roller, Fritz, Mohajerani, Emad, Seeger, Werner, Herberg, Ulrike, Sommer, Natascha, Gall, Henning, Richter, Manuel J

“…The ratios of tricuspid annular plane systolic excursion (TAPSE)/echocardiographically measured systolic pulmonary artery pressure (PASP), fractional area…”
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Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy by Zheng, Xiang, Turkowski, Kati, Mora, Javier, Brüne, Bernhard, Seeger, Werner, Weigert, Andreas, Savai, Rajkumar

“…Cancer research in recent decades has highlighted the potential influence of the tumor microenvironment on the progression and metastasis of most known cancer…”
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Macrophage and Tumor Cell Cross-Talk Is Fundamental for Lung Tumor Progression: We Need to Talk by Sarode, Poonam, Schaefer, Martina Barbara, Grimminger, Friedrich, Seeger, Werner, Savai, Rajkumar

“…Regardless of the promising results of certain immune checkpoint blockers, current immunotherapeutics have met a bottleneck concerning response rate, toxicity,…”
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Relevance of the TAPSE/PASP ratio in pulmonary arterial hypertension by Tello, Khodr, Axmann, Jens, Ghofrani, Hossein A., Naeije, Robert, Narcin, Newroz, Rieth, Andreas, Seeger, Werner, Gall, Henning, Richter, Manuel J.

“…The ratio of echocardiography-derived tricuspid annular plane systolic excursion (TAPSE) and pulmonary arterial systolic pressure (PASP) has recently been…”
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Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis by Kheirollahi, Vahid, Wasnick, Roxana M., Biasin, Valentina, Vazquez-Armendariz, Ana Ivonne, Chu, Xuran, Moiseenko, Alena, Weiss, Astrid, Wilhelm, Jochen, Zhang, Jin-San, Kwapiszewska, Grazyna, Herold, Susanne, Schermuly, Ralph T., Mari, Bernard, Li, Xiaokun, Seeger, Werner, Günther, Andreas, Bellusci, Saverio, El Agha, Elie

“…Idiopathic pulmonary fibrosis (IPF) is a fatal disease in which the intricate alveolar network of the lung is progressively replaced by fibrotic scars…”
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Reserve of Right Ventricular-Arterial Coupling in the Setting of Chronic Overload by Tello, Khodr, Dalmer, Antonia, Axmann, Jens, Vanderpool, Rebecca, Ghofrani, Hossein A, Naeije, Robert, Roller, Fritz, Seeger, Werner, Sommer, Natascha, Wilhelm, Jochen, Gall, Henning, Richter, Manuel J

“…Right ventricular (RV) maladaptation and failure determine outcome in pulmonary hypertension. The adaptation of RV function to loading (RV-pulmonary arterial…”
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More on Single-Beat Estimation of Right Ventriculoarterial Coupling in Pulmonary Arterial Hypertension by Tello, Khodr, Richter, Manuel J, Axmann, Jens, Buhmann, Martin, Seeger, Werner, Naeije, Robert, Ghofrani, Hossein Ardeschir, Gall, Henning

“…The RV then uses a dimensional or "heterometric" adaptation (Starling's law of the heart) to maintain flow output in response to metabolic demand (3). Because…”
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Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension by Savai, Rajkumar, Al-Tamari, Hamza M, Sedding, Daniel, Kojonazarov, Baktybek, Muecke, Christian, Teske, Rebecca, Capecchi, Mario R, Weissmann, Norbert, Grimminger, Friedrich, Seeger, Werner, Schermuly, Ralph Theo, Pullamsetti, Soni Savai

“…Activation of the transcription factor FoxO1 ameliorates vascular remodeling in pulmonary hypertension, pointing to a potential new therapeutic strategy for…”
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Evaluation and Prognostic Relevance of Right Ventricular-Arterial Coupling in Pulmonary Hypertension by Richter, Manuel J, Peters, Dana, Ghofrani, Hossein A, Naeije, Robert, Roller, Fritz, Sommer, Natascha, Gall, Henning, Grimminger, Friedrich, Seeger, Werner, Tello, Khodr

“…Richter et al discuss their study on the prognostic relevance of right ventricular (RV)-arterial coupling in pulmonary hypertension (PH). RV function is the…”
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The Giessen Pulmonary Hypertension Registry: Survival in pulmonary hypertension subgroups by Gall, Henning, MD, PhD, Felix, Janine F., MD, PhD, Schneck, Franziska K., MD, Milger, Katrin, MD, Sommer, Natascha, PhD, Voswinckel, Robert, MD, Franco, Oscar H., MD, PhD, Hofman, Albert, MD, PhD, Schermuly, Ralph T., PhD, Weissmann, Norbert, PhD, Grimminger, Friedrich, PhD, Seeger, Werner, MD, Ghofrani, Hossein A., MD

“…Background Pulmonary hypertension (PH) is a severe, progressive disease. Although 5 PH subgroups are recognized, reports on survival have focused mainly on…”
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The European IPF registry (eurIPFreg): baseline characteristics and survival of patients with idiopathic pulmonary fibrosis by Guenther, Andreas, Krauss, Ekaterina, Tello, Silke, Wagner, Jasmin, Paul, Bettina, Kuhn, Stefan, Maurer, Olga, Heinemann, Sabine, Costabel, Ulrich, Barbero, María Asunción Nieto, Müller, Veronika, Bonniaud, Philippe, Vancheri, Carlo, Wells, Athol, Vasakova, Martina, Pesci, Alberto, Sofia, Matteo, Klepetko, Walter, Seeger, Werner, Drakopanagiotakis, Fotios, Crestani, Bruno

“…Since 2009, IPF patients across Europe are recruited into the eurIPFreg, providing epidemiological data and biomaterials for translational research. The…”
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Macrophage and cancer cell cross-talk via CCR2 and CX3CR1 is a fundamental mechanism driving lung cancer by Schmall, Anja, Al-Tamari, Hamza M, Herold, Susanne, Kampschulte, Marian, Weigert, Andreas, Wietelmann, Astrid, Vipotnik, Natasha, Grimminger, Friedrich, Seeger, Werner, Pullamsetti, Soni Savai, Savai, Rajkumar

“…Recent studies indicate that tumor-associated macrophages (MΦ) with an M2 phenotype can influence cancer progression and metastasis, but the regulatory…”
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The emerging role of epigenetics in pulmonary hypertension by Gamen, Elisabetta, Seeger, Werner, Pullamsetti, Soni Savai

“…Epigenetics is usually defined as the study of changes in phenotype and gene expression not related to sequence alterations, but rather the chemical…”
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Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis by El Agha, Elie, Moiseenko, Alena, Kheirollahi, Vahid, De Langhe, Stijn, Crnkovic, Slaven, Kwapiszewska, Grazyna, Szibor, Marten, Kosanovic, Djuro, Schwind, Felix, Schermuly, Ralph T., Henneke, Ingrid, MacKenzie, BreAnne, Quantius, Jennifer, Herold, Susanne, Ntokou, Aglaia, Ahlbrecht, Katrin, Braun, Thomas, Morty, Rory E., Günther, Andreas, Seeger, Werner, Bellusci, Saverio

“…Idiopathic pulmonary fibrosis (IPF) is a form of progressive interstitial lung disease with unknown etiology. Due to a lack of effective treatment, IPF is…”
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Updated Treatment Algorithm of Pulmonary Arterial Hypertension by Galiè, Nazzareno, MD, Corris, Paul A., MD, Frost, Adaani, MD, Girgis, Reda E., MD, Granton, John, MD, Jing, Zhi Cheng, MD, Klepetko, Walter, MD, McGoon, Michael D., MD, McLaughlin, Vallerie V., MD, Preston, Ioana R., MD, Rubin, Lewis J., MD, Sandoval, Julio, MD, Seeger, Werner, MD, Keogh, Anne, MD

“…The demands on a pulmonary arterial hypertension (PAH) treatment algorithm are multiple and in some ways conflicting. The treatment algorithm usually includes…”
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Pulmonary Hypertension Due to Left Heart Diseases by Vachiéry, Jean-Luc, MD, Adir, Yochai, MD, MHA, Barberà, Joan Albert, MD, PhD, Champion, Hunter, MD, Coghlan, John Gerard, MD, Cottin, Vincent, MD, PhD, De Marco, Teresa, MD, Galiè, Nazzareno, MD, Ghio, Stefano, MD, Gibbs, J. Simon R., MD, Martinez, Fernando, MD, Semigran, Marc, MD, Simonneau, Gerald, MD, Wells, Athol, MD, MBSHB, Seeger, Werner, MD, PhD

“…Pulmonary hypertension (PH), a common complication of left heart diseases (LHD), negatively impacts symptoms, exercise capacity, and outcome. Although the true…”
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Cardiac Magnetic Resonance Imaging-Based Right Ventricular Strain Analysis for Assessment of Coupling and Diastolic Function in Pulmonary Hypertension by Tello, Khodr, Dalmer, Antonia, Vanderpool, Rebecca, Ghofrani, Hossein A., Naeije, Robert, Roller, Fritz, Seeger, Werner, Wilhelm, Jochen, Gall, Henning, Richter, Manuel J.

“…This study sought to compare cardiac magnetic resonance (CMR) imaging-derived right ventricular (RV) strain and invasively measured pressure-volume…”
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