Search Results - "SEED, THOMAS"

A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures by Singh, Vijay K., Seed, Thomas M.

“…Purpose: The increasing global risk of nuclear and radiological accidents or attacks has driven renewed research interest in developing medical countermeasures…”
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Radiation countermeasures for hematopoietic acute radiation syndrome: growth factors, cytokines and beyond by Singh, Vijay K., Seed, Thomas M.

“…The intent of this article is to report the status of some of the pharmaceuticals currently in late stage development for possible use for individuals…”
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Pharmacological management of ionizing radiation injuries: current and prospective agents and targeted organ systems by Singh, Vijay K, Seed, Thomas M

“…: There is a limited array of currently available medicinals that are useful for either the prevention, mitigation or treatment of bodily injuries arising from…”
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How necessary are animal models for modern drug discovery? by Singh, Vijay K, Seed, Thomas M

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Entolimod as a radiation countermeasure for acute radiation syndrome by Singh, Vijay K., Seed, Thomas M.

“…•Salmonella typhimurium flagellin is a stable protein and natural activator of NF-κB.•Entolimod is truncated flagellin retaining radioprotective…”
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A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part II. Countermeasures for limited indications, internalized radionuclides, emesis, late effects, and agents demonstrating efficacy in large animals with or without FDA IND status by Singh, Vijay K., Garcia, Melissa, Seed, Thomas M.

“…Purpose: The threat of a radiological/nuclear event is a critical concern for all government agencies involved in national security and public health…”
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Development of gamma-tocotrienol as a radiation medical countermeasure for the acute radiation syndrome: current status and future perspectives by Singh, Vijay K, Seed, Thomas M

“…The possibility of exposure to high doses of total- or partial-body ionizing radiation at a high dose rate due to radiological/nuclear accidents or terrorist…”
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The potential value of 5-androstenediol in countering acute radiation syndrome by Singh, Vijay K., Seed, Thomas M.

“…•5-androstenediol (5-AED) is an androstene series steroid hormone involved in the maintenance of innate immunity.•This agent has been shown to be effective…”
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BIO 300: a promising radiation countermeasure under advanced development for acute radiation syndrome and the delayed effects of acute radiation exposure by Singh, Vijay K, Seed, Thomas M

“…There are no radioprotectors currently approved by the United States Food and Drug Administration (US FDA) for either the hematopoietic acute radiation…”
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Colony-stimulating factors for the treatment of the hematopoietic component of the acute radiation syndrome (H-ARS): A review by Singh, Vijay K., Newman, Victoria L., Seed, Thomas M.

“…•Threats of radiation exposure require availability of treatment information.•No drugs or biologics have been approved by US FDA to treat H-ARS.•G-CSF and…”
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Repurposing Pharmaceuticals Previously Approved by Regulatory Agencies to Medically Counter Injuries Arising Either Early or Late Following Radiation Exposure by Singh, Vijay K., Seed, Thomas M

“…The increasing risks of radiological or nuclear attacks or associated accidents have served to renew interest in developing radiation medical countermeasures…”
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Vitamin E: tocopherols and tocotrienols as potential radiation countermeasures by Singh, Vijay K., Beattie, Lindsay A., Seed, Thomas M.

“…Despite the potential devastating health consequences of intense total-body irradiation, and the decades of research, there still remains a dearth of safe and…”
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Metabolomics-based predictive biomarkers of radiation injury and countermeasure efficacy: current status and future perspectives by Singh, Vijay K, Seed, Thomas M, Cheema, Amrita K

“…There is an urgent need for specific and sensitive bioassays to augment biodosimetric assessments of unwanted and excessive radiation exposures that originate…”
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The safety and efficacy of interleukin 11 for radiation injury by Singh, Vijay K, Seed, Thomas M

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Analysis of the metabolomic profile in serum of irradiated nonhuman primates treated with Ex-Rad, a radiation countermeasure by Li, Yaoxiang, Girgis, Michael, Wise, Stephen Y., Fatanmi, Oluseyi O., Seed, Thomas M., Maniar, Manoj, Cheema, Amrita K., Singh, Vijay K.

“…To date, the United States Food and Drug Administration (FDA) has approved four drugs to mitigate hematopoietic acute radiation syndrome and all four are…”
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A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part III. Countermeasures under early stages of development along with 'standard of care' medicinal and procedures not requiring regulatory approval for use by Singh, Vijay K., Hanlon, Briana K., Santiago, Paola T., Seed, Thomas M.

“…Purpose: Terrorist attacks, with their intent to maximize psychological and economic damage as well as inflicting sickness and death on given targeted…”
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Pathology of acute sub-lethal or near-lethal irradiation of nonhuman primates prophylaxed with the nutraceutical, gamma tocotrienol by Singh, Vijay K., Wise, Stephen Y., Fatanmi, Oluseyi O., Petrus, Sarah A., Carpenter, Alana D., Lugo-Roman, Luis A., Lee, Sang-Ho, Hauer-Jensen, Martin, Seed, Thomas M.

“…Exposure to high, marginally lethal doses or higher of ionizing radiation, either intentional or accidental, results in injury to various organs. Currently,…”
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Histopathological studies of nonhuman primates exposed to supralethal doses of total- or partial-body radiation: influence of a medical countermeasure, gamma-tocotrienol by Singh, Vijay K., Wise, Stephen Y., Fatanmi, Oluseyi O., Petrus, Sarah A., Carpenter, Alana D., Lee, Sang-Ho, Hauer-Jensen, Martin, Seed, Thomas M.

“…Despite remarkable scientific progress over the past six decades within the medical arts and in radiobiology in general, limited radiation medical…”
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Medical Countermeasures for Radiation Exposure and Related Injuries: Characterization of Medicines, FDA-Approval Status and Inclusion into the Strategic National Stockpile by Singh, Vijay K, Romaine, Patricia L.P, Seed, Thomas M

“…ABSTRACTWorld events over the past decade have highlighted the threat of nuclear terrorism as well as an urgent need to develop radiation countermeasures for…”
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Metabolomic studies in tissues of mice treated with amifostine and exposed to gamma-radiation by Cheema, Amrita K., Li, Yaoxiang, Girgis, Michael, Jayatilake, Meth, Simas, Madison, Wise, Stephen Y., Olabisi, Ayodele O., Seed, Thomas M., Singh, Vijay K.

“…Although multiple radioprotectors are currently being investigated preclinically for efficacy and safety, few studies have investigated concomitant metabolic…”
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