Search Results - "SEEBURG, P. H"

Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus by Niewoehner, B., Single, F. N., Hvalby, Ø., Jensen, V., Meyer zum Alten Borgloh, S., Seeburg, P. H., Rawlins, J. N. P., Sprengel, R., Bannerman, D. M.

“…Novel spatially restricted genetic manipulations can be used to assess contributions made by synaptic plasticity to learning and memory, not just selectively…”
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Spatial memory dissociations in mice lacking GluR1 by Bannerman, D. M, Reisel, D, Schmitt, W. B, Deacon, R. M. J, Flint, J, Borchardt, T, Seeburg, P. H, Rawlins, J. N. P

“…Gene-targeted mice lacking the AMPA receptor subunit GluR1 (GluR-A) have deficits in hippocampal CA3-CA1 long-term potentiation. We now report that they showed…”
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Deletion of Glutamate Receptor-A (GluR-A) AMPA Receptor Subunits Impairs One-Trial Spatial Memory by Sanderson, D. J, Gray, A, Simon, A, Taylor, A. M, Deacon, R. M. J, Seeburg, P. H, Sprengel, R, Good, M. A, Rawlins, J. N. P, Bannerman, D. M

“…Genetically modified mice lacking the glutamate receptor A (GluR-A) subunit of the AMPA receptor (GluR-A-/- mice) display normal spatial reference memory but…”
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Hippocampal NMDA receptors are important for behavioural inhibition but not for encoding associative spatial memories by Taylor, A. M., Bus, T., Sprengel, R., Seeburg, P. H., Rawlins, J. N. P., Bannerman, D. M.

“…The idea that an NMDA receptor (NMDAR)-dependent long-term potentiation-like process in the hippocampus is the neural substrate for associative spatial…”
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Restoration of spatial working memory by genetic rescue of GluR-A-deficient mice by Bannerman, D M, Schmitt, W B, Sprengel, R, Mack, V, Draft, R W, Seeburg, P H, Deacon, R M J, Rawlins, J N P

“…Gene-targeted mice lacking the AMPA receptor subunit GluR-A (also called GluR1 encoded by the gene Gria1,) have deficits in hippocampal CA3-CA1 long-term…”
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Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2 by Seeburg, Peter H, Higuchi, Miyoko, Maas, Stefan, Single, Frank N, Hartner, Jochen, Rozov, Andrei, Burnashev, Nail, Feldmeyer, Dirk, Sprengel, Rolf

“…RNA editing by site-selective deamination of adenosine to inosine alters codons and splicing in nuclear transcripts, and therefore protein function. ADAR2…”
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The role of the GluR-A (GluR1) AMPA receptor subunit in learning and memory by Sanderson, D J, Good, M A, Seeburg, P H, Sprengel, R, Rawlins, J N P, Bannerman, D M

“…It is widely believed that synaptic plasticity may provide the neural mechanism that underlies certain kinds of learning and memory in the mammalian brain. The…”
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A complex mosaic of high-affinity kainate receptors in rat brain by Wisden, W, Seeburg, PH

“…The significance for CNS function of glutamate-gated cation channels that exhibit high-affinity kainate sites is not understood. Such receptors, which on…”
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A Molecular Determinant for Submillisecond Desensitization in Glutamate Receptors by Mosbacher, J., Schoepfer, R., Monyer, H., Burnashev, N., Seeburg, P. H., Ruppersberg, J. P.

“…The decay of excitatory postsynaptic currents in central neurons mediated by $\alpha$-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptors is…”
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The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon by Wisden, W, Laurie, DJ, Monyer, H, Seeburg, PH

“…The expression patterns of 13 GABAA receptor subunit encoding genes (alpha 1-alpha 6, beta 1-beta 3, gamma 1-gamma 3, delta) were determined in adult rat brain…”
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Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA by Laurie, DJ, Seeburg, PH

“…Developmental and regional alternative splicing of the NMDAR1 subunit gene transcript was examined by in situ hybridization in the developing and adult rat…”
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The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum by Laurie, DJ, Seeburg, PH, Wisden, W

“…In an effort to determine subunit compositions of in vivo GABAA receptors, the cellular localization of 13 subunit encoding mRNAs (alpha 1-alpha 6, beta 1-beta…”
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A Comparison of GluR-A-Deficient and Wild-Type Mice on a Test Battery Assessing Sensorimotor, Affective, and Cognitive Behaviors by Bannerman, D. M, Deacon, R. M. J, Brady, S, Bruce, A, Sprengel, R, Seeburg, P. H, Rawlins, J. N. P

“…Previous studies have demonstrated a spatial working memory deficit in glutamate receptor (GluR)-A (GluR1) AMPA receptor subunit knockout mice. The present…”
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The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray by Tolle, TR, Berthele, A, Zieglgansberger, W, Seeburg, PH, Wisden, W

“…Diverse arrays of glutamate-gated channels in the spinal cord and associated pathways are partly responsible for sensory input, for altered sensitivity to…”
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Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit by Burnashev, N, Monyer, H, Seeburg, P H, Sakmann, B

“…Functionally diverse GluR channels of the AMPA subtype are generated by the assembly of GluR-A, -B, -C, and -D subunits into homo- and heteromeric channels…”
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Control of Kinetic Properties of AMPA Receptor Channels by Nuclear RNA Editing by Lomeli, Hilda, Mosbacher, Johannes, Melcher, Thorsten, Höger, Thomas, Jörg R. P. Geiger, Kuner, Thomas, Monyer, Hannah, Higuchi, Miyoko, Bach, Alfred, Seeburg, Peter H.

“…AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor channels mediate the fast component of excitatory postsynaptic currents in the central…”
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Importance of AMPA Receptors for Hippocampal Synaptic Plasticity But Not for Spatial Learning by Zamanillo, Daniel, Sprengel, Rolf, Hvalby, Øivind, Jensen, Vidar, Burnashev, Nail, Rozov, Andrei, Katharina M. M. Kaiser, Köster, Helmut J., Borchardt, Thilo, Worley, Paul, Lübke, Joachim, Frotscher, Michael, Kelly, Peter H., Sommer, Bernd, Andersen, Per, Seeburg, Peter H., Sakmann, Bert

“…Gene-targeted mice lacking the L-α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunit GluR-A exhibited normal development, life expectancy,…”
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The TINS/TiPS Lecture. The molecular biology of mammalian glutamate receptor channels by Seeburg, P H

“…In native brain membranes the principal excitatory neurotransmitter L-glutamate activates cation-conducting channels with distinct biophysical and…”
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Codon-improved Cre recombinase (iCre) expression in the mouse by Shimshek, D.R., Kim, J., Hübner, M.R., Spergel, D.J., Buchholz, F., Casanova, E., Stewart, A.F., Seeburg, P.H., Sprengel, R.

“…By applying the mammalian codon usage to Cre recombinase, we improved Cre expression, as determined by immunoblot and functional analysis, in three different…”
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Domain Interaction between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95 by Kornau, Hans-Christian, Schenker, Leslie T., Kennedy, Mary B., Seeburg, Peter H.

“…The N-methyl-D-aspartate (NMDA) receptor subserves synaptic glutamate-induced transmission and plasticity in central neurons. The yeast two-hybrid system was…”
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