Search Results - "SEDEGAH, M"

Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8⁺ T Cell Immunity by Epstein, J. E., Tewari, K., Lyke, K. E., Sim, B. K. L., Billingsley, P. F., Laurens, M. B., Gunasekera, A., Chakravarty, S., James, E. R., Sedegah, M., Richman, A., Velmurugan, S., Reyes, S., Li, M., Tucker, K., Ahumada, A., Ruben, A. J., Li, T., Stafford, R., Eappen, A. G., Tamminga, C., Bennett, J. W., Ockenhouse, C. F., Murphy, J. R., Komisar, J., Thomas, N., Loyevsky, M., Birkett, A., Plowe, C. V., Loucq, C., Edelman, R., Richie, T. L., Seder, R. A., Hoffman, S. L.

“…Our goal is to develop a vaccine that sustainably prevents Plasmodium falciparum (Pf) malaria in ≥80% of recipients. Pf sporozoites (PfSPZ) administered by…”
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Plasma concentrations of transforming growth factor beta 1 in non-progressive HIV-1 infection correlates with markers of disease progression by Maina, Edward K., Abana, C.Z., Bukusi, E.A., Sedegah, M., Lartey, M., Ampofo, W.K.

“…•T-cell phenotypes are not restored after ART/viral suppression in HIV-1 infection.•TGF β 1 and IL-10 may explain lack of CD4+ T-cells recovery in progressive…”
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CD4+ T cell counts in initiation of antiretroviral therapy in HIV infected asymptomatic individuals; controversies and inconsistencies by Maina, E.K, Bonney, E.Y, Bukusi, E.A, Sedegah, M, Lartey, M, Ampofo, W.K

“…Highlights • Assesses available data on optimal time to initiate therapy in HIV-infected asymptomatic individuals with respect to CD4+ T cell threshold. •…”
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Cross-protection between attenuated Plasmodium berghei and P. yoelii sporozoites by SEDEGAH, M, WEISS, W.W, HOFFMAN, S.L

“…An attenuated Plasmodium falciparum sporozoite (PfSPZ) vaccine is under development, in part, based on studies in mice with P. berghei. We used P. berghei and…”
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Protection against Malaria by Immunization with Plasmid DNA Encoding Circumsporozoite Protein by Sedegah, Martha, Hedstrom, Richard, Hobart, Peter, Hoffman, Stephen L.

“…Immunization with irradiated sporozoites protects animals and humans against malaria, and the circumsporozoite protein is a target of this protective immunity…”
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Interleukin 12 Induction of Interferon γ-Dependent Protection Against Malaria by Sedegah, Martha, Finkelman, Fred, Hoffman, Stephen L.

“…Intraperitoneal injection of recombinant Interleukin 12 (rIL-12) at 30 ng/day for 5 days beginning 1 to 2 days before sporozoite challenge or administration of…”
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Interleukin-12- and Gamma Interferon-Dependent Protection against Malaria Conferred by CpG Oligodeoxynucleotide in Mice by GRAMZINSKI, Robert A, DOOLAN, Denise L, SEDEGAH, Martha, DAVIS, Heather L, KRIEG, Arthur M, HOFFMAN, Stephen L

“…ERRATUM ( vol. 70 , p. 5338 ) Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg…”
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Reduced immunogenicity of DNA vaccine plasmids in mixtures by SEDEGAH, M, CHAROENVIT, Y, NARUM, D. L, CARUCCI, D. J, ROGERS, W. O, MINH, L, BELMONTE, M, MAJAM, V. F, ABOT, S, GANESHAN, H, KUMAR, S, BACON, D. J, STOWERS, A

“…We measured the ability of nine DNA vaccine plasmids encoding candidate malaria vaccine antigens to induce antibodies and interferon-gamma responses when…”
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Plasmid Vaccine Expressing Granulocyte-Macrophage Colony-Stimulating Factor Attracts Infiltrates Including Immature Dendritic Cells into Injected Muscles by Haddad, Diana, Ramprakash, Jayanthi, Sedegah, Martha, Charoenvit, Yupin, Baumgartner, Roxanne, Kumar, Sanjai, Hoffman, Stephen L, Weiss, Walter R

“…Plasmid-encoded GM-CSF (pGM-CSF) is an adjuvant for genetic vaccines; however, little is known about how pGM-CSF enhances immunogenicity. We now report that…”
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Complete protection against Plasmodium yoelii by adoptive transfer of a CD8+ cytotoxic T-cell clone recognizing sporozoite surface protein 2 by KHUSMITH, S, SEDEGAH, M, HOFFMAN, S. L

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Effect on antibody and T-cell responses of mixing five GMP-produced DNA plasmids and administration with plasmid expressing GM-CSF by Sedegah, M, Charoenvit, Y, Aguiar, J, Sacci, J, Hedstrom, R, Kumar, S, Belmonte, A, Lanar, D E, Jones, T R, Abot, E, Druilhe, P, Corradin, G, Epstein, J E, Richie, T L, Carucci, D J, Hoffman, S L

“…One potential benefit of DNA vaccines is the capacity to elicit antibody and T-cell responses against multiple antigens at the same time by mixing plasmids…”
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CD8+ T Cells (Cytotoxic/Suppressors) are Required for Protection in Mice Immunized with Malaria Sporozoites by Weiss, Walter R., Sedegah, Martha, Beaudoin, Richard L., Miller, Louis H., Good, Michael F.

“…In recent malaria sporozoite vaccine trials in humans and mice, antibodies to the sporozoite coat protein have given only modest protection against sporozoite…”
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Sterile protection of monkeys against malaria after administration of interleukin-12 by Hoffman, S.L, Crutcher, J.M, Puri, S.K, Ansari, A.A, Villinger, F, Franke, E.D, Singh, P.P, Finkelman, F, Gately, M.K, Dutta, G.P, Sedegah, M

“…An estimated 300-500 million new infections and 1.5-2.7 million deaths attributed to malaria occur annually in the developing world, and every year tens of…”
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The Infectivity of Plasmodium yoelii in Different Strains of Mice by Belmonte, M, Jones, T. R, Lu, M, Arcilla, R, Smalls, T, Belmonte, A, Rosenbloom, J, Carucci, D. J, Sedegah, M

“…We evaluated the effect of using Medium 199 alone and Medium 199 supplemented with 5% normal mouse serum, 5% fetal calf serum, 5% bovine serum albumin or 5%…”
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Recombinant Attenuated Toxoplasma gondii Expressing the Plasmodium yoelii Circumsporozoite Protein Provides Highly Effective Priming for CD8+ T Cell-Dependent Protective Immunity Against Malaria by Charest, Hugues, Sedegah, Martha, Yap, George S, Gazzinelli, Ricardo T, Caspar, Patricia, Hoffman, Stephen L, Sher, Alan

“…The protozoan parasite Toxoplasma gondii elicits strong cell-mediated immunity against itself as well as nonspecific resistance against other pathogens and…”
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Protection against malaria by immunization with a Plasmodium yoelii circumsporozoite protein nucleic acid vaccine by Hoffman, S L, Sedegah, M, Hedstrom, R C

“…Nucleic acid vaccines provide an exciting new alternative approach to developing the multiantigen vaccines designed to induce protective antibody and T-cell…”
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Immunogenicity and protective efficacy of a Plasmodium yoelii Hsp60 DNA vaccine in BALB/c mice by SANCHEZ, Gloria I, SEDEGAH, Martha, ROGERS, William O, JONES, Trevor R, SACCI, John, WITNEY, Adam, CARUCCI, Daniel J, KUMAR, Nirbhay, HOFFMAN, Stephen L

“…The gene encoding the 60-kDa heat shock protein of Plasmodium yoelii (PyHsp60) was cloned into the VR1012 and VR1020 mammalian expression vectors. Groups of 10…”
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Safety, immunogenicity, and efficacy of a malaria sporozoite vaccine administered with monophosphoryl lipid A, cell wall skeleton of mycobacteria, and squalane as adjuvant by Hoffman, S L, Edelman, R, Bryan, J P, Schneider, I, Davis, J, Sedegah, M, Gordon, D, Church, P, Gross, M, Silverman, C

“…A Plasmodium falciparum circumsporozoite protein (PfCSP) recombinant fusion protein, R32NS1(81), formulated with monophosphoryl lipid A, cell wall skeleton of…”
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Nucleic acid malaria vaccines. Current status and potential by Hoffman, S L, Doolan, D L, Sedegah, M, Gramzinski, R, Wang, H, Gowda, K, Hobart, P, Margalith, M, Norman, J, Hedstrom, R C

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Characterization of Plasmodium yoelii monoclonal antibodies directed against stage-specific sporozoite antigens by CHAROENVIT, Y, LEEF, M. F, YUAN, L. F, SEDEGAH, M, BEAUDOIN, R. L

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