Search Results - "SECKLER, M. M"

Advances in D-Amino Acids in Neurological Research by Seckler, James M, Lewis, Stephen J

“…D-amino acids have been known to exist in the human brain for nearly 40 years, and they continue to be a field of active study to today. This review article…”
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Nitrosyl factors play a vital role in the ventilatory depressant effects of fentanyl in unanesthetized rats by Seckler, James M., Grossfield, Alan, May, Walter J., Getsy, Paulina M., Lewis, Stephen J.

“…There is an urgent need to understand the intracellular mechanisms by which synthetic opioids, such as fentanyl, depress breathing. We used L-NAME…”
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d-Cystine di(m)ethyl ester reverses the deleterious effects of morphine on ventilation and arterial blood gas chemistry while promoting antinociception by Gaston, Benjamin, Baby, Santhosh M., May, Walter J., Young, Alex P., Grossfield, Alan, Bates, James N., Seckler, James M., Wilson, Christopher G., Lewis, Stephen J.

“…We have identified thiolesters that reverse the negative effects of opioids on breathing without compromising antinociception. Here we report the effects of d…”
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Glutathione ethyl ester reverses the deleterious effects of fentanyl on ventilation and arterial blood-gas chemistry while prolonging fentanyl-induced analgesia by Jenkins, Michael W., Khalid, Faiza, Baby, Santhosh M., May, Walter J., Young, Alex P., Bates, James N., Cheng, Feixiong, Seckler, James M., Lewis, Stephen J.

“…There is an urgent need to develop novel compounds that prevent the deleterious effects of opioids such as fentanyl on minute ventilation while, if possible,…”
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Detection of trace concentrations of S-nitrosothiols by means of a capacitive sensor by Seckler, James M, Meyer, Nikki M, Burton, Spencer T, Bates, James N, Gaston, Benjamin, Lewis, Stephen J

“…Small molecule S-nitrosothiols are a class of endogenous chemicals in the body, which have been implicated in a variety of biological functions. However, the…”
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S-nitroso-L-cysteine stereoselectively blunts the adverse effects of morphine on breathing and arterial blood gas chemistry while promoting analgesia by Getsy, Paulina M., Young, Alex P., Bates, James N., Baby, Santhosh M., Seckler, James M., Grossfield, Alan, Hsieh, Yee-Hsee, Lewis, Tristan H.J., Jenkins, Michael W., Gaston, Benjamin, Lewis, Stephen J.

“…S-nitrosothiols exert multiple effects on neural processes in the central and peripheral nervous system. This study shows that intravenous infusion of…”
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The ventilatory depressant actions but not the antinociceptive effects of morphine are blunted in rats receiving intravenous infusion of L-cysteine ethyl ester by Lewis, Tristan H.J., May, Walter J., Young, Alex P., Bates, James N., Baby, Santhosh M., Getsy, Paulina M., Ryan, Rita M., Hsieh, Yee-Hsee, Seckler, James M., Lewis, Stephen J.

“…This study demonstrates that intravenous infusion of the cell-penetrant thiol ester, L-cysteine ethyl ester (L-CYSee), to adult male Sprague-Dawley rats…”
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Hypoxia releases S-nitrosocysteine from carotid body glomus cells-relevance to expression of the hypoxic ventilatory response by Seckler, James M, Getsy, Paulina M, May, Walter J, Gaston, Benjamin, Baby, Santhosh M, Lewis, Tristan H J, Bates, James N, Lewis, Stephen J

“…We have provided indirect pharmacological evidence that hypoxia may trigger release of the S-nitrosothiol, S-nitroso-L-cysteine (L-CSNO), from primary carotid…”
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Multiple approaches for large-scale CO2 capture by adsorption with 13X zeolite in multi-stage fluidized beds assessment by Prado, D. S., Vilarrasa-García, E., Sampronha, E., Beleli, Y. S., Moreira, F. S., Paiva, J. L., Roux, G. A. C. L., Bastos-Neto, M., Azevedo, D. C. S., Silva, E. C. N., Seckler, M. M.

“…Adsorption is a promising technology for reducing CO 2 emissions from combustion gases. However, some issues must be considered when designing large-scale…”
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S-Nitroso-L-Cysteine Stereoselectively Blunts the Deleterious Effects of Fentanyl on Breathing While Augmenting Antinociception in Freely-Moving Rats by Getsy, Paulina M., Baby, Santhosh M., Gruber, Ryan B., Gaston, Benjamin, Lewis, Tristan H. J., Grossfield, Alan, Seckler, James M., Hsieh, Yee-Hsee, Bates, James N., Lewis, Stephen J.

“…Endogenous and exogenously administered S-nitrosothiols modulate the activities of central and peripheral systems that control breathing. We have unpublished…”
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Allosteric Suppression of HIV-1 Reverse Transcriptase Structural Dynamics upon Inhibitor Binding by Seckler, James M., Barkley, Mary D., Wintrode, Patrick L.

“…Efavirenz is a second-generation nonnucleoside reverse transcriptase inhibitor (NNRTI) and a common component of clinically approved anti-AIDS regimens. NNRTIs…”
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In Situ Observation of Epitaxial Growth during Evaporative Simultaneous Crystallization from Aqueous Electrolytes in Droplets by Penha, Frederico M., Andrade, Fábio R. D., Lanzotti, Amanda S., Moreira Junior, Paulo F., Zago, Gustavo P., Seckler, Marcelo M.

“…In this study, crystallization phenomena were investigated by real-time in situ observation of seeded droplets under evaporation using a self-developed…”
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Thoughts on the role of endogenous D‐cysteine in neuronal function by Seckler, James M.

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Designing product listing pages—Effects on sales and users’ cognitive workload by Schmutz, P., Roth, S.P., Seckler, M., Opwis, K.

“…Product listing pages, where information on multiple products are displayed, represent a vital point of an E-commerce website on which consumer decisions are…”
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Surveying nonvisual arrestins reveals allosteric interactions between functional sites by Seckler, James M., Robinson, Emily N., Lewis, Stephen J., Grossfield, Alan

“…Arrestins are important scaffolding proteins that are expressed in all vertebrate animals. They regulate cell‐signaling events upon binding to active G‐protein…”
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Development of static mixers for miscible fluids in laminar flow with the use of computational fluid dynamics (CFD) by Joaquim Jr, C. F., Reynol, A., Cekinski, E., Seckler, M. M., Nunhez, J. R.

“…Static mixers with improved performance were developed from CFD simulations in a stepwise approach. The relevant geometric features of simple mixer designs and…”
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D-cysteine ethyl ester and D-cystine dimethyl ester reverse the deleterious effects of morphine on arterial blood-gas chemistry and Alveolar-arterial gradient in anesthetized rats by Getsy, Paulina M., Young, Alex P., Grossfield, Alan, Seckler, James M., Wilson, Christopher G., Gaston, Benjamin, Bates, James N., Lewis, Stephen J.

“…We determined whether intravenous injections of the membrane-permeable ventilatory stimulants, D-cysteine ethyl ester (ethyl…”
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Possible Roles of Permafrost Melting, Atmospheric Transport, and Solar Irradiance in the Development of Major Coronavirus and Influenza Pandemics by Hofmeister, Anne M, Seckler, James M, Criss, Genevieve M

“…Major pandemics involving respiratory viruses develop semi-regularly and require a large flux of novel viruses, yet their origination is equivocal. This paper…”
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Membrane Distillation Crystallization Applied to Brine Desalination: A Hierarchical Design Procedure by Pantoja, Carlos E, Nariyoshi, Yuri N, Seckler, Marcelo M

“…A mathematical model for the design of membrane distillation (MD) processes applied to water recovery from brines is developed in this study. The highly saline…”
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Functional evidence that S-nitroso-L-cysteine may be a candidate carotid body neurotransmitter by Getsy, Paulina M, Coffee, Gregory A, Bates, James N, Baby, Santhosh M, Seckler, James M, Palmer, Lisa A, Lewis, Stephen J

“…The primary objective of the present study was to provide further evidence that the endogenous S-nitrosothiol, S-nitroso-L-cysteine (L-CSNO), plays an…”
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