Search Results - "SEBTI, Said"

PTEN counteracts FBXL2 to promote IP3R3- and Ca 2+ -mediated apoptosis limiting tumour growth by Kuchay, Shafi, Giorgi, Carlotta, Simoneschi, Daniele, Pagan, Julia, Missiroli, Sonia, Saraf, Anita, Florens, Laurence, Washburn, Michael P, Collazo-Lorduy, Ana, Castillo-Martin, Mireia, Cordon-Cardo, Carlos, Sebti, Said M, Pinton, Paolo, Pagano, Michele

“…In response to environmental cues that promote IP3 (inositol 1,4,5-trisphosphate) generation, IP3 receptors (IP3Rs) located on the endoplasmic reticulum allow…”
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PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth by Kuchay, Shafi, Giorgi, Carlotta, Simoneschi, Daniele, Pagan, Julia, Missiroli, Sonia, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Collazo-Lorduy, Ana, Castillo-Martin, Mireia, Cordon-Cardo, Carlos, Sebti, Said M., Pinton, Paolo, Pagano, Michele

“…PTEN, a known tumour suppressor, inhibits the FXBL2-dependent degradation of IP3R3, an IP3 receptor, thus augmenting IP3R3-mediated calcium release from the…”
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The GTPase KRAS suppresses the p53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells by Yang, Hua, Xiang, Shengyan, Kazi, Aslamuzzaman, Sebti, Said M.

“…In human cancer cells that harbor mutant KRAS and WT p53 (p53), KRAS contributes to the maintenance of low p53 levels. Moreover, KRAS depletion stabilizes and…”
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Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation by Mahajan, Kiran, Coppola, Domenico, Challa, Sridevi, Fang, Bin, Chen, Y Ann, Zhu, Weiwei, Lopez, Alexis S, Koomen, John, Engelman, Robert W, Rivera, Charlene, Muraoka-Cook, Rebecca S, Cheng, Jin Q, Schönbrunn, Ernst, Sebti, Said M, Earp, H Shelton, Mahajan, Nupam P

“…The AKT/PKB kinase is a key signaling component of one of the most frequently activated pathways in cancer and is a major target of cancer drug development…”
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Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity by Siddiquee, Khandaker, Zhang, Shumin, Guida, Wayne C, Blaskovich, Michelle A, Greedy, Benjamin, Lawrence, Harshani R, Yip, M.L. Richard, Jove, Richard, McLaughlin, Mark M, Lawrence, Nicholas J, Sebti, Said M, Turkson, James

“…S3I-201 (NSC 74859) is a chemical probe inhibitor of Stat3 activity, which was identified from the National Cancer Institute chemical libraries by using…”
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Ral GTPase Down-regulation Stabilizes and Reactivates p53 to Inhibit Malignant Transformation by Tecleab, Awet, Zhang, Xiaolei, Sebti, Said M.

“…Ral GTPases are critical effectors of Ras, yet the molecular mechanism by which they induce malignant transformation is not well understood. In this study, we…”
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Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors by Kazi, Aslamuzzaman, Xiang, Shengyan, Yang, Hua, Chen, Liwei, Kennedy, Perry, Ayaz, Muhammad, Fletcher, Steven, Cummings, Christopher, Lawrence, Harshani R, Beato, Francisca, Kang, Ya'an, Kim, Michael P, Delitto, Andrea, Underwood, Patrick W, Fleming, Jason B, Trevino, Jose G, Hamilton, Andrew D, Sebti, Said M

“…Mutant KRAS is a major driver of pancreatic oncogenesis and therapy resistance, yet KRAS inhibitors are lacking in the clinic. KRAS requires farnesylation for…”
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δ-Tocotrienol, a natural form of vitamin E, inhibits pancreatic cancer stem-like cells and prevents pancreatic cancer metastasis by Husain, Kazim, Centeno, Barbara A, Coppola, Domenico, Trevino, Jose, Sebti, Said M, Malafa, Mokenge P

“…The growth, metastasis, and chemotherapy resistance of pancreatic ductal adenocarcinoma (PDAC) is characterized by the activation and growth of…”
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MDMX Overexpression Prevents p53 Activation by the MDM2 Inhibitor Nutlin by Hu, Baoli, Gilkes, Daniele M., Farooqi, Bilal, Sebti, Said M., Chen, Jiandong

“…The p53 tumor suppressor plays a key role in maintaining genomic stability and protection against malignant transformation. MDM2 and MDMX are both p53-binding…”
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Combined HMG-COA reductase and prenylation inhibition in treatment of CCM by Nishimura, Sayoko, Mishra-Gorur, Ketu, Park, JinSeok, Surovtseva, Yulia V., Sebti, Said M., Levchenko, Andre, Louvi, Angeliki, Gunel, Murat

“…Cerebral cavernous malformations (CCMs) are common vascular anomalies that develop in the central nervous system and, more rarely, the retina. The lesions can…”
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Vitamin E δ-tocotrienol augments the antitumor activity of gemcitabine and suppresses constitutive NF-κB activation in pancreatic cancer by Husain, Kazim, Francois, Rony A, Yamauchi, Teruo, Perez, Marta, Sebti, Said M, Malafa, Mokenge P

“…The NF-κB transcription factor functions as a crucial regulator of cell survival and chemoresistance in pancreatic cancer. Recent studies suggest that…”
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Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells by Zhou, Liang, Pei, Xinyan, Zhang, Yu, Ning, Yanxia, Li, Lin, Hu, Xiaoyan, Chalasani, Sri Lakshmi, Sharma, Kanika, Nkwocha, Jewel, Yu, Jonathan, Bandyopadhyay, Dipankar, Sebti, Said M, Grant, Steven

“…The relationship between the checkpoint kinase Chk1 and the STAT3 pathway was examined in multiple myeloma cells. Gene expression profiling of U266 cells…”
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Phase II Study of the Mitogen-Activated Protein Kinase 1/2 Inhibitor Selumetinib in Patients With Advanced Hepatocellular Carcinoma by O'NEIL, Bert H, GOFF, Laura W, SEBTI, Said M, SULLIVAN, Daniel M, WOOK KAUH, John Sae, STROSBERG, Jonathan R, BEKAII-SAAB, Tanios S, LEE, Ruey-Min, KAZI, Aslamuzzaman, MOORE, Dominic T, LEAROYD, Maria, LUSH, Richard M

“…PURPOSE Hepatocellular carcinoma (HCC) is a common and deadly malignancy with few systemic therapy options. The RAF/mitogen-activated protein kinase kinase…”
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Mevalonate Metabolism Regulates Basal Breast Cancer Stem Cells and Is a Potential Therapeutic Target by Ginestier, Christophe, Monville, Florence, Wicinski, Julien, Cabaud, Olivier, Cervera, Nathalie, Josselin, Emmanuelle, Finetti, Pascal, Guille, Arnaud, Larderet, Gaelle, Viens, Patrice, Sebti, Said, Bertucci, François, Birnbaum, Daniel, Charafe-Jauffret, Emmanuelle

“…There is increasing evidence that breast tumors are organized in a hierarchy, with a subpopulation of tumorigenic cancer cells, the cancer stem cells (CSCs),…”
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Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine by Carbone, Michele, Amelio, Ivano, Affar, El Bachir, Brugarolas, James, Cannon-Albright, Lisa A, Cantley, Lewis C., Cavenee, Webster K., Chen, Zhijian, Croce, Carlo M., Andrea, Alan D’, Gandara, David, Giorgi, Carlotta, Jia, Wei, Lan, Qing, Mak, Tak Wah, Manley, James L., Mikoshiba, Katsuhiko, Onuchic, Jose N, Pass, Harvey I., Pinton, Paolo, Prives, Carol, Rothman, Nathaniel, Sebti, Said M., Turkson, James, Wu, Xifeng, Yang, Haining, Yu, Herbert, Melino, Gerry

“…The relative contribution of intrinsic genetic factors and extrinsic environmental ones to cancer aetiology and natural history is a lengthy and debated issue…”
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Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX by Phan, Jason, Li, Zhenyu, Kasprzak, Agnieszka, Li, Baozong, Sebti, Said, Guida, Wayne, Schönbrunn, Ernst, Chen, Jiandong

“…MDM2 and MDMX function as key regulators of p53 by binding to its N terminus, inhibiting its transcriptional activity, and promoting degradation. MDM2 and MDMX…”
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Inhibiting Isoprenylation Suppresses FcεRI-Mediated Mast Cell Function and Allergic Inflammation by Dailey, Jordan M, Kee, Sydney A, Tharakan, Anuj, Kazi, Aslamuzzaman, Burchett, Jason R, Kolawole, Elizabeth Motunrayo, Boyd Ballance, William, Kotha, Aditya, Le, Quang T, Schwartz, Lawrence B, Straus, David B, Martin, Rebecca K, Sebti, Said M, Ryan, John J

“…IgE-mediated mast cell activation is a driving force in allergic disease in need of novel interventions. Statins, long used to lower serum cholesterol, have…”
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Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway by NEFEDOVA, Yulia, NAGARAJ, Srinivas, ROSENBAUER, Amsler, MURO-CACHO, Carlos, SEBTI, Said M, GABRILOVICH, Dmitry I

“…Abnormal dendritic cell differentiation and accumulation of immunosuppressive myeloid cells in cancer is one of the major factors of tumor nonresponsiveness…”
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Identification of novel inhibitors that disrupt STAT3-DNA interaction from a γ-AApeptide OBOC combinatorial library by Teng, Peng, Zhang, Xiaolei, Wu, Haifan, Qiao, Qiao, Sebti, Said M, Cai, Jianfeng

“…From a γ-AApeptide-based one-bead-one-compound (OBOC) combinatorial library, we identified γ-AApeptides that can selectively inhibit STAT3-DNA interaction and…”
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Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases by Schonbrunn, Ernst, Betzi, Stephane, Alam, Riazul, Martin, Mathew P, Becker, Andreas, Han, Huijong, Francis, Rawle, Chakrasali, Ramappa, Jakkaraj, Sudhakar, Kazi, Aslamuzzaman, Sebti, Said M, Cubitt, Christopher L, Gebhard, Anthony W, Hazlehurst, Lori A, Tash, Joseph S, Georg, Gunda I

“…Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases that act as key regulatory elements in cell cycle progression. We describe the development…”
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