Search Results - "SEBOKOVA, Elena"

Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans by Finan, Brian, Ma, Tao, Ottaway, Nickki, Müller, Timo D, Habegger, Kirk M, Heppner, Kristy M, Kirchner, Henriette, Holland, Jenna, Hembree, Jazzminn, Raver, Christine, Lockie, Sarah H, Smiley, David L, Gelfanov, Vasily, Yang, Bin, Hofmann, Susanna, Bruemmer, Dennis, Drucker, Daniel J, Pfluger, Paul T, Perez-Tilve, Diego, Gidda, Jaswant, Vignati, Louis, Zhang, Lianshan, Hauptman, Jonathan B, Lau, Michele, Brecheisen, Mathieu, Uhles, Sabine, Riboulet, William, Hainaut, Emmanuelle, Sebokova, Elena, Conde-Knape, Karin, Konkar, Anish, DiMarchi, Richard D, Tschöp, Matthias H

“…We report the discovery and translational therapeutic efficacy of a peptide with potent, balanced co-agonism at both of the receptors for the incretin hormones…”
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Dipeptidyl peptidase IV inhibitors: the next generation of new promising therapies for the management of type 2 diabetes by Sebokova, Elena, Christ, Andreas D, Boehringer, Markus, Mizrahi, Jacques

“…Type 2 diabetes is a chronic metabolic disease characterized by the presence of both fasting and postprandial hyperglycemia which is a result of pancreas…”
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Effects of pioglitazone and fenofibrate co-administration on bone biomechanics and histomorphometry in ovariectomized rats by Smith, Susan Y., Samadfam, Rana, Chouinard, Luc, Awori, Malaika, Bénardeau, Agnes, Bauss, Frieder, Guldberg, Robert E., Sebokova, Elena, Wright, Matthew B.

“…Pioglitazone, the peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist is an effective therapy for type 2 diabetes, but has been associated with…”
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Effects of aleglitazar, a balanced dual peroxisome proliferator-activated receptor α/γ agonist on glycemic and lipid parameters in a primate model of the metabolic syndrome by Hansen, Barbara C, Tigno, Xenia T, Bénardeau, Agnes, Meyer, Markus, Sebokova, Elena, Mizrahi, Jacques

“…Glycemic control and management of dyslipidemia to reduce cardiovascular risk are major therapeutic goals in individuals with type 2 diabetes mellitus (T2DM)…”
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Medium-chain fatty acids ameliorate insulin resistance caused by high-fat diets in rats by Wein, Silvia, Wolffram, Siegfried, Schrezenmeir, Jürgen, Gašperiková, Daniela, Klimeš, Iwar, Šeböková, Elena

“…Background High dietary intake of saturated fat impairs insulin sensitivity and lipid metabolism. The influence of fatty acid chain length, however, is not yet…”
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Increased thyroid volume and frequency of thyroid disorders signs in schoolchildren from nitrate polluted area by Tajtáková, Mária, Semanová, Zuzana, Tomková, Zlatica, Szökeová, Edita, Majoroš, Jozef, Rádiková, Žofia, Šeböková, Elena, Klimeš, Iwar, Langer, Pavel

“…Thyroid volume (ThV) and echogenicity by ultrasound were estimated in 324 schoolchildren (aged between 10 and 13-years) from high nitrate area (HNA) located in…”
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Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance by Madsen, Lise, Guerre-Millo, Michéle, Flindt, Esben N, Berge, Kjetil, Tronstad, Karl Johan, Bergene, Elin, Sebokova, Elena, Rustan, Arild C, Jensen, Jørgen, Mandrup, Susanne, Kristiansen, Karsten, Klimes, Iwar, Staels, Bart, Berge, Rolf K

“…Tetradecylthioacetic acid (TTA) is a non-beta-oxidizable fatty acid analog, which potently regulates lipid homeostasis. Here we evaluate the ability of TTA to…”
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Increased thyroid volume, prevalence of thyroid antibodies and impaired fasting glucose in young adults from organochlorine cocktail polluted area: Outcome of transgenerational transmission? by Langer, Pavel, Kočan, Anton, Tajtáková, Mária, Koška, Juraj, Rádiková, Žofia, Kšinantová, Lucia, Imrich, Richard, Hučková, Miloslava, Drobná, Beáta, Gašperíková, Daniela, Šeböková, Elena, Klimeš, Iwar

“…In 137 females (F) and 94 males (M) aged 21–35 years from organochlorines (OCs) polluted area (POLL) increased thyroid volume (ThV), prevalence of antibodies…”
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Cytosolic citrate and malonyl-CoA regulation in rat muscle in vivo by Saha, A.K, Laybutt, D.R, Dean, D, Vavvas, D, Sebokova, E, Ellis, B, Klimes, I, Kraegen, E.W, Shafrir, E, Ruderman, N.B

“…In liver, insulin and glucose acutely increase the concentration of malonyl-CoA by dephosphorylating and activating acetyl-CoA carboxylase (ACC). In contrast,…”
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Possible effects of environmental nitrates and toxic organochlorines on human thyroid in highly polluted areas in Slovakia by Rádiková, Zofia, Tajtáková, Mária, Kocan, Anton, Trnovec, Tomás, Seböková, Elena, Klimes, Iwar, Langer, Pavel

“…Heavy environmental pollution resulting from uncontrolled industrial and agricultural activities has occurred in several areas of Slovakia. So far, field…”
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Fish from industrially polluted freshwater as the main source of organochlorinated pollutants and increased frequency of thyroid disorders and dysglycemia by Langer, Pavel, Kočan, Anton, Tajtaková, Mária, Petrík, Ján, Chovancová, Jana, Drobná, Beáta, Jursa, Stanislav, Rádiková, Žofia, Koška, Juraj, Kšinantová, Lucia, Hučková, Miloslava, Imrich, Richard, Wimmerová, Soňa, Gašperíková, Daniela, Shishiba, Yoshimasa, Trnovec, Tomáš, Šeböková, Elena, Klimeš, Iwar

“…In a certain area of Michalovce district in East Slovakia, heavy industrial pollution by polychlorinated biphenyls (PCBs) developed in 1955–1984 and very high…”
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A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents by Finan, Brian, Yang, Bin, Ottaway, Nickki, Smiley, David L, Ma, Tao, Clemmensen, Christoffer, Chabenne, Joe, Zhang, Lianshan, Habegger, Kirk M, Fischer, Katrin, Campbell, Jonathan E, Sandoval, Darleen, Seeley, Randy J, Bleicher, Konrad, Uhles, Sabine, Riboulet, William, Funk, Jürgen, Hertel, Cornelia, Belli, Sara, Sebokova, Elena, Conde-Knape, Karin, Konkar, Anish, Drucker, Daniel J, Gelfanov, Vasily, Pfluger, Paul T, Müller, Timo D, Perez-Tilve, Diego, DiMarchi, Richard D, Tschöp, Matthias H

“…A rationally designed peptide agonist that targets three key hormone receptors reduces obesity and its complications in a manner superior to other agonists. We…”
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Thyroid ultrasound volume, structure and function after long-term high exposure of large population to polychlorinated biphenyls, pesticides and dioxin by Langer, Pavel, Tajtáková, Mária, Kočan, Anton, Petrík, Ján, Koška, Juraj, Kšinantová, Lucia, Rádiková, Žofia, Ukropec, Jozef, Imrich, Richard, Hučková, Miloslava, Chovancová, Jana, Drobná, Beáta, Jursa, Stanislav, Vlček, Miroslav, Bergman, Aake, Athanasiadou, Maria, Hovander, Lotta, Shishiba, Yoshimasa, Trnovec, Tomáš, Šeböková, Elena, Klimeš, Iwar

“…We examined 2046 adults (834 males and 1212 females aged 20–75 years) from polluted district in East Slovakia (POLL) and two neighboring upstream and upwind…”
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Possible effects of persistent organochlorinated pollutants cocktail on thyroid hormone levels and pituitary–thyroid interrelations by Langer, Pavel, Kočan, Anton, Tajtáková, Mária, Rádiková, Žofia, Petrík, Ján, Koška, Juraj, Kšinantová, Lucia, Imrich, Richard, Hučková, Miloslava, Chovancová, Jana, Drobná, Beáta, Jursa, Stanislav, Bergman, Aake, Athanasiadou, Maria, Hovander, Lotta, Gašperíková, Daniela, Trnovec, Tomáš, Šeböková, Elena, Klimeš, Iwar

“…In polluted district of Michalovce in East Slovakia (POLL) and two districts with background pollution (BCGR) 2046 adults (834 males and 1212 females aged…”
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Possible Effects of Polychlorinated Biphenyls and Organochlorinated Pesticides on the Thyroid after Long-term Exposure to Heavy Environmental Pollution by Langer, Pavel, Kočan, Anton, Tajtáková, Mária, Petrík, Ján, Chovancová, Jana, Drobná, Beáta, Jursa, Stanislav, Pavúk, Marián, Koška, Juraj, Trnovec, Tomáš, Šeböková, Elena, Klimes, Iwar

“…The purpose of this work was to study the effects of high environmental exposure to polychlorinated biphenyls (PCBs) and other organochhrines on the thyroid…”
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Taspoglutide, an Analog of Human Glucagon-Like Peptide-1 with Enhanced Stability and in Vivo Potency by Sebokova, Elena, Christ, Andreas D, Wang, Haiyan, Sewing, Sabine, Dong, Jesse Z, Taylor, John, Cawthorne, Michael A, Culler, Michael D

“…Taspoglutide is a novel analog of human glucagon-like peptide-1 [hGLP-1(7-36)NH2] in clinical development for the treatment of type 2 diabetes. Taspoglutide…”
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A Novel Partial Agonist of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) Recruits PPARγ-Coactivator-1α, Prevents Triglyceride Accumulation, and Potentiates Insulin Signaling in Vitro by Burgermeister, Elke, Schnoebelen, Astride, Flament, Angele, Benz, Jörg, Stihle, Martine, Gsell, Bernard, Rufer, Arne, Ruf, Armin, Kuhn, Bernd, Märki, Hans Peter, Mizrahi, Jacques, Sebokova, Elena, Niesor, Eric, Meyer, Markus

“…Partial agonists of peroxisome proliferator-activated receptor-γ (PPARγ), also termed selective PPARγ modulators, are expected to uncouple insulin…”
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Discovery of carmegliptin: A potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes by Mattei, Patrizio, Boehringer, Markus, Di Giorgio, Patrick, Fischer, Holger, Hennig, Michael, Huwyler, Joerg, Koçer, Buelent, Kuhn, Bernd, Loeffler, Bernd M., MacDonald, Alexander, Narquizian, Robert, Rauber, Etienne, Sebokova, Elena, Sprecher, Urs

“…Design, synthesis, and SAR are described for a class of DPP-IV inhibitors based on aminobenzo[ a]quinolizines with non-aromatic substituents in the S1…”
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Combination treatment with pioglitazone and fenofibrate attenuates pioglitazone-mediated acceleration of bone loss in ovariectomized rats by Samadfam, Rana, Awori, Malaika, Bénardeau, Agnes, Bauss, Frieder, Sebokova, Elena, Wright, Matthew, Smith, Susan Y

“…Peroxisome proliferator-activated receptor (PPAR) γ agonists, such as pioglitazone (Pio), improve glycemia and lipid profile but are associated with bone loss…”
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Rhesus Macaques Develop Metabolic Syndrome With Reversible Vascular Dysfunction Responsive to Pioglitazone by XIUQIN ZHANG, RONGLI ZHANG, KAITAO LI, HUILIANG ZHANG, YAN ZHANG, CHAO HAN, YI DING, HUI WANG, NING HOU, YULI LIU, SHUJIANG SHANG, CHUANYUN LI, RAAB, Susanne, SEBOKOVA, Elena, HEPING CHENG, HUANG, Paul L, WEN ZHENG, JUE WANG, NA LIU, TIANGANG ZHU, LIFANG XUE, ZHENTAO SONG, JIAMING MAO

“…The metabolic syndrome (MetS) is a constellation of clinical features that include central obesity, hypertension, atherogenic dyslipidemia, and insulin…”
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