Search Results - "SEARS, CATHERINE R"

DNA repair targeted therapy: The past or future of cancer treatment? by Gavande, Navnath S, VanderVere-Carozza, Pamela S, Hinshaw, Hilary D, Jalal, Shadia I, Sears, Catherine R, Pawelczak, Katherine S, Turchi, John J

“…The repair of DNA damage is a complex process that relies on particular pathways to remedy specific types of damage to DNA. The range of insults to DNA…”
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Knowledge Gaps and Research Priorities in Immune Checkpoint Inhibitor-related Pneumonitis. An Official American Thoracic Society Research Statement by Sears, Catherine R, Peikert, Tobias, Possick, Jennifer D, Naidoo, Jarushka, Nishino, Mizuki, Patel, Sandip P, Camus, Philippe, Gaga, Mina, Garon, Edward B, Gould, Michael K, Limper, Andrew H, Montgrain, Philippe R, Travis, William D, Rivera, M Patricia

“…Immune checkpoint inhibitors (ICIs) have revolutionized cancer care but are associated with unique adverse events, including potentially life-threatening…”
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DNA repair as an emerging target for COPD-lung cancer overlap by Sears, Catherine R.

“…Cigarette smoking is the leading cause of lung cancer and chronic obstructive pulmonary disease (COPD). Many of the detrimental effects of cigarette smoke have…”
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Xeroderma Pigmentosum Complementation Group C (XPC): Emerging Roles in Non-Dermatologic Malignancies by Nasrallah, Nawar Al, Wiese, Benjamin M, Sears, Catherine R

“…Xeroderma pigmentosum complementation group C (XPC) is a DNA damage recognition protein essential for initiation of global-genomic nucleotide excision repair…”
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XPC protects against smoking- and carcinogen-induced lung adenocarcinoma by Zhou, Huaxin, Saliba, Jacob, Sandusky, George E, Sears, Catherine R

“…Cigarette smoke (CS) contains hundreds of carcinogens and is a potent inducer of oxidative and bulky DNA damage, which when insufficiently repaired leads to…”
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Discovery and development of novel DNA-PK inhibitors by targeting the unique Ku–DNA interaction by Gavande, Navnath S, VanderVere-Carozza, Pamela S, Pawelczak, Katherine S, Mendoza-Munoz, Pamela, Vernon, Tyler L, Hanakahi, Leslyn A, Summerlin, Matthew, Dynlacht, Joseph R, Farmer, Annabelle H, Sears, Catherine R, Nasrallah, Nawar Al, Garrett, Joy, Turchi, John J

“…Abstract DNA-dependent protein kinase (DNA-PK) plays a critical role in the non-homologous end joining (NHEJ) repair pathway and the DNA damage response (DDR)…”
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Complex Cisplatin-Double Strand Break (DSB) Lesions Directly Impair Cellular Non-Homologous End-Joining (NHEJ) Independent of Downstream Damage Response (DDR) Pathways by Sears, Catherine R., Turchi, John J.

“…The treatment for advanced stage non-small cell lung cancer (NSCLC) often includes platinum-based chemotherapy and IR. Cisplatin and IR combination therapy…”
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Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9 by Fu, Yongyao, Pajulas, Abigail, Wang, Jocelyn, Zhou, Baohua, Cannon, Anthony, Cheung, Cherry Cheuk Lam, Zhang, Jilu, Zhou, Huaxin, Fisher, Amanda Jo, Omstead, David T., Khan, Sabrina, Han, Lei, Renauld, Jean-Christophe, Paczesny, Sophie, Gao, Hongyu, Liu, Yunlong, Yang, Lei, Tighe, Robert M., Licona-Limón, Paula, Flavell, Richard A., Takatsuka, Shogo, Kitamura, Daisuke, Sun, Jie, Bilgicer, Basar, Sears, Catherine R., Yang, Kai, Kaplan, Mark H.

“…Although IL-9 has potent anti-tumor activity in adoptive cell transfer therapy, some models suggest that it can promote tumor growth. Here, we show that IL-9…”
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Low-Coverage Whole Genome Sequencing Using Laser Capture Microscopy with Combined Digital Droplet PCR: An Effective Tool to Study Copy Number and Kras Mutations in Early Lung Adenocarcinoma Development by Mickler, Elizabeth A, Zhou, Huaxin, Phang, Tzu L, Geraci, Mark W, Stearman, Robert S, Sears, Catherine R

“…Defining detailed genomic characterization of early tumor progression is critical to identifying key regulators and pathways in carcinogenesis as potentially…”
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Recognition of DNA Termini by the C-Terminal Region of the Ku80 and the DNA-Dependent Protein Kinase Catalytic Subunit by Woods, Derek S, Sears, Catherine R, Turchi, John J

“…DNA double strand breaks (DSBs) can be generated by endogenous cellular processes or exogenous agents in mammalian cells. These breaks are highly variable with…”
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Lung Cancer Screening: Millions of Promises and More Challenges by Smyth, Robert, Sears, Catherine R.

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Hemophagocytic Lymphohistiocytosis in the Medical ICU: A Single-Institution Cohort Study on Acute Liver Failure and Mortality by Al Nasrallah, Nawar, Al-Hader, Ahmad, Samala, Niharika, Sears, Catherine R

“…Hemophagocytic lymphohistiocytosis is a life-threatening hyperinflammatory disorder that is associated with high morbidity and mortality in the ICU. It has…”
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Biomarkers in Lung Cancer by Sears, Catherine R., Mazzone, Peter J.

“…Biomarkers that focus on lung cancer risk assessment, detection, prognosis, diagnosis, and personalized treatment are in various stages of development. This…”
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Age, Sex, Smoking, and Race: Is Progress Being Made in Lung Cancer Screening Eligibility? by Sears, Catherine R., Rivera, M. Patricia

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Biomarkers in Pulmonary Nodule Diagnosis: Is It Time to Put Away the Biopsy Needle? by Al Nasrallah, Nawar, Sears, Catherine R.

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Patient Perspectives on Shared Decision-Making in Lung Cancer Screening: To Teach or To Trust? by Duncan, Francesca C., Sears, Catherine R.

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DNA Repair Capacity for Personalizing Risk and Treatment Response − Assay Development and Optimization in Human Peripheral Blood Mononuclear Cells (PBMCs) by Nasrallah, Nawar Al, Zhou, Huaxin, Smith, Patricia A., Sears, Catherine R.

“…DNA repair capacity (DRC) is the ability of a cell to repair DNA damage. Differential DRC plays an important role in human disease, including lung and other…”
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Invasive Fungal Infections in the Era of Biologics by Arnold, Tamra M., PharmD, BCPS, Sears, Catherine R., MD, Hage, Chadi A., MD

“…With the advent and widespread use of immunomodulating biologic agents, emerging invasive fungal infections are reported increasingly. To date there is no…”
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DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer by Sears, Catherine R., Cooney, Sean A., Chin-Sinex, Helen, Mendonca, Marc S., Turchi, John J.

“…•Combination cisplatin–radiation causes sequence dependent cytotoxicity in non-small cell lung cancer.•Treatment with combination cisplatin-ionizing radiation…”
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Assessment of Advanced Diagnostic Bronchoscopy Outcomes for Peripheral Lung Lesions: A Delphi Consensus Definition of Diagnostic Yield and Recommendations for Patient-centered Study Designs. An Official American Thoracic Society/American College of Chest Physicians Research Statement by Gonzalez, Anne V, Silvestri, Gerard A, Korevaar, Daniel A, Gesthalter, Yaron, Almeida, Nisha D, Chen, Alex, Gilbert, Chris R, Illei, Peter B, Navani, Neal, Pasquinelli, Mary M, Pastis, Nicholas J, Sears, Catherine R, Shojaee, Samira, Solomon, Stephen B, Steinfort, Daniel P, Maldonado, Fabien, Rivera, M Patricia, Yarmus, Lonny B

“…Advanced diagnostic bronchoscopy targeting the lung periphery has developed at an accelerated pace over the last two decades, while evidence to support…”
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