Search Results - "SCOTT, Geoff I"
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Transfer of gold nanoparticles from the water column to the estuarine food web
Published in Nature nanotechnology (01-07-2009)“…Within the next five years the manufacture of large quantities of nanomaterials may lead to unintended contamination of terrestrial and aquatic ecosystems 1 …”
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Prior exposure to microcystin alters host gut resistome and is associated with dysregulated immune homeostasis in translatable mouse models
Published in Scientific reports (07-07-2022)“…A strong association between exposure to the common harmful algal bloom toxin microcystin and the altered host gut microbiome has been shown. We tested the…”
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Subchronic Oral Cylindrospermopsin Exposure Alters the Host Gut Microbiome and Is Associated with Progressive Hepatic Inflammation, Stellate Cell Activation, and Mild Fibrosis in a Preclinical Study
Published in Toxins (01-12-2022)“…Epidemiological studies have reported a strong association between liver injury and incidences of hepatocellular carcinoma in sections of humans globally…”
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Environmental microcystin targets the microbiome and increases the risk of intestinal inflammatory pathology via NOX2 in underlying murine model of Nonalcoholic Fatty Liver Disease
Published in Scientific reports (19-06-2019)“…With increased climate change pressures likely to influence harmful algal blooms, exposure to microcystin, a known hepatotoxin and a byproduct of…”
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Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21
Published in American journal of physiology: Gastrointestinal and liver physiology (01-10-2019)“…Nonalcoholic fatty liver disease (NAFLD) is an emerging global pandemic. Though significant progress has been made in unraveling the pathophysiology of the…”
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Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood-brain barrier dysfunction, and neurodegeneration are NLRP3 and S100B dependent
Published in Toxicology (Amsterdam) (01-09-2021)“…Nonalcoholic fatty liver disease (NAFLD) has been shown to be associated with extrahepatic comorbidities including neuronal inflammation and Alzheimer’s-like…”
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Early microcystin-LR exposure-linked inflammasome activation in mice causes development of fatty liver disease and insulin resistance
Published in Environmental toxicology and pharmacology (01-11-2020)“…[Display omitted] •Early exposure of microcystin primes mouse liver for hepatic inflammation in adulthood.•Early microcystin priming followed by high fat diet…”
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Higher intestinal and circulatory lactate associated NOX2 activation leads to an ectopic fibrotic pathology following microcystin co-exposure in murine fatty liver disease
Published in Comparative biochemistry and physiology. Toxicology & pharmacology (01-12-2020)“…Clinical studies implicated an increased risk of intestinal fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). Our previous studies have shown…”
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Sequence Variation among Group III F-Specific RNA Coliphages from Water Samples and Swine Lagoons
Published in Applied and Environmental Microbiology (01-02-2006)“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Microcystin exposure worsens nonalcoholic fatty liver disease associated ectopic glomerular toxicity via NOX-2-MIR21 axis
Published in Environmental toxicology and pharmacology (01-01-2020)“…•Microcystin exposure in NAFLD hastens mesangial cell activation.•Mesangial cell proinflammatory events are a fallout of NOX 2 activation following microcystin…”
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11
Fish tissue quality in near-coastal areas of the Gulf of Mexico receiving point source discharges
Published in The Science of the total environment (04-02-2002)“…The objective of this study was to determine inorganic and organic contaminant concentrations in edible tissue of fish collected from eight coastal areas…”
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