Search Results - "SCHWEIZER, Patrick"

siRNA-Finder (si-Fi) Software for RNAi-Target Design and Off-Target Prediction by Lück, Stefanie, Kreszies, Tino, Strickert, Marc, Schweizer, Patrick, Kuhlmann, Markus, Douchkov, Dimitar

“…RNA interference (RNAi) is a technique used for transgene-mediated gene silencing based on the mechanism of posttranscriptional gene silencing (PTGS). PTGS is…”
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HIGS: Host-Induced Gene Silencing in the Obligate Biotrophic Fungal Pathogen Blumeria graminis by Nowara, Daniela, Gay, Alexandra, Lacomme, Christophe, Shaw, Jane, Ridout, Christopher, Douchkov, Dimitar, Hensel, Götz, Kumlehn, Jochen, Schweizer, Patrick

“…Powdery mildew fungi are obligate biotrophic pathogens that only grow on living hosts and cause damage in thousands of plant species. Despite their agronomical…”
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The Symptom Complex of Familial Sinus Node Dysfunction and Myocardial Noncompaction Is Associated With Mutations in the HCN4 Channel by Schweizer, Patrick A., MD, Schröter, Julian, BSc, Greiner, Sebastian, MD, Haas, Jan, PhD, Yampolsky, Pessah, PhD, Mereles, Derliz, MD, Buss, Sebastian J., MD, Seyler, Claudia, PhD, Bruehl, Claus, PhD, Draguhn, Andreas, MD, Koenen, Michael, PhD, Meder, Benjamin, MD, Katus, Hugo A., MD, Thomas, Dierk, MD

“…Abstract Background Inherited arrhythmias were originally considered isolated electrical defects. There is growing evidence that ion channel dysfunction also…”
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Atrial fibrillation complicated by heart failure induces distinct remodeling of calcium cycling proteins by Lugenbiel, Patrick, Wenz, Fabian, Govorov, Katharina, Schweizer, Patrick A, Katus, Hugo A, Thomas, Dierk

“…Atrial fibrillation (AF) and heart failure (HF) are two of the most common cardiovascular diseases. They often coexist and account for significant morbidity…”
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Upregulation of K(2P)3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation by Schmidt, Constanze, Wiedmann, Felix, Voigt, Niels, Zhou, Xiao-Bo, Heijman, Jordi, Lang, Siegfried, Albert, Virginia, Kallenberger, Stefan, Ruhparwar, Arjang, Szabó, Gábor, Kallenbach, Klaus, Karck, Matthias, Borggrefe, Martin, Biliczki, Peter, Ehrlich, Joachim R, Baczkó, István, Lugenbiel, Patrick, Schweizer, Patrick A, Donner, Birgit C, Katus, Hugo A, Dobrev, Dobromir, Thomas, Dierk

“…Antiarrhythmic management of atrial fibrillation (AF) remains a major clinical challenge. Mechanism-based approaches to AF therapy are sought to increase…”
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Comparative Evaluation of Two Pulsed Field Ablation Systems for Atrial Fibrillation: Insights from Real-World Clinical Implementation and Short-Term Outcomes by Zylla, Maura M., Mages, Christine, Rahm, Ann-Kathrin, Wiedmann, Felix, Schweizer, Patrick A., Thomas, Dierk, Frey, Norbert, Lugenbiel, Patrick

“…Pulsed field ablation (PFA) is a safe and effective technology for catheter ablation of atrial fibrillation (AF). Multiple PFA-platforms for AF-ablation have…”
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Differential accumulation of callose, arabinoxylan and cellulose in nonpenetrated versus penetrated papillae on leaves of barley infected with Blumeria graminis f. sp. hordei by Chowdhury, Jamil, Henderson, Marilyn, Schweizer, Patrick, Burton, Rachel A, Fincher, Geoffrey B, Little, Alan

“…In plants, cell walls are one of the first lines of defence for protecting cells from successful invasion by fungal pathogens and are a major factor in basal…”
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Therapeutic targeting of two-pore-domain potassium (K(2P)) channels in the cardiovascular system by Wiedmann, Felix, Schmidt, Constanze, Lugenbiel, Patrick, Staudacher, Ingo, Rahm, Ann-Kathrin, Seyler, Claudia, Schweizer, Patrick A, Katus, Hugo A, Thomas, Dierk

“…The improvement of treatment strategies in cardiovascular medicine is an ongoing process that requires constant optimization. The ability of a therapeutic…”
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HERG K+ channel-dependent apoptosis and cell cycle arrest in human glioblastoma cells by Staudacher, Ingo, Jehle, Julian, Staudacher, Kathrin, Pledl, Hans-Werner, Lemke, Dieter, Schweizer, Patrick A, Becker, Rüdiger, Katus, Hugo A, Thomas, Dierk

“…Glioblastoma (GB) is associated with poor patient survival owing to uncontrolled tumor proliferation and resistance to apoptosis. Human ether-a-go-go-related…”
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Histone deacetylase 2-dependent ventricular electrical remodeling in a porcine model of early heart failure by Syren, Pascal, Rahm, Ann-Kathrin, Schweizer, Patrick A., Bruehl, Claus, Katus, Hugo A., Frey, Norbert, Thomas, Dierk, Lugenbiel, Patrick

“…Heart failure (HF) is linked to electrical remodeling that promotes ventricular arrhythmias. Underlying molecular signaling is insufficiently understood, in…”
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GPD1L-A306del modifies sodium current in a family carrying the dysfunctional SCN5A-G1661R mutation associated with Brugada syndrome by Semino, Francesca, Darche, Fabrice F., Bruehl, Claus, Koenen, Michael, Skladny, Heyko, Katus, Hugo A., Frey, Norbert, Draguhn, Andreas, Schweizer, Patrick A.

“…Loss-of-function variants of SCN5A , encoding the sodium channel alpha subunit Nav1.5 are associated with high phenotypic variability and multiple cardiac…”
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Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling by Yampolsky, Pessah, Koenen, Michael, Mosqueira, Matias, Geschwill, Pascal, Nauck, Sebastian, Witzenberger, Monika, Seyler, Claudia, Fink, Thomas, Kruska, Mathieu, Bruehl, Claus, Schwoerer, Alexander P., Ehmke, Heimo, Fink, Rainer H. A., Draguhn, Andreas, Thomas, Dierk, Katus, Hugo A., Schweizer, Patrick A.

“…HCN channels underlie the depolarizing funny current (I f ) that contributes importantly to cardiac pacemaking. I f is upregulated in failing and infarcted…”
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Improved Generation of Human Induced Pluripotent Stem Cell-Derived Cardiac Pacemaker Cells Using Novel Differentiation Protocols by Darche, Fabrice F., Ullrich, Nina D., Huang, Ziqiang, Koenen, Michael, Rivinius, Rasmus, Frey, Norbert, Schweizer, Patrick A.

“…Current protocols for the differentiation of human-induced pluripotent stem cells (hiPSC) into cardiomyocytes only generate a small amount of cardiac pacemaker…”
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A Distinct Cardiomyopathy: HCN4 Syndrome Comprising Myocardial Noncompaction, Bradycardia, Mitral Valve Defects, and Aortic Dilation by Schweizer, Patrick A., Koenen, Michael, Katus, Hugo A., Thomas, Dierk

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Host-Induced Gene Silencing in Barley Powdery Mildew Reveals a Class of Ribonuclease-Like Effectors by PLIEGO, Clara, NOWARA, Daniela, SCHWEIZER, Patrick, BINDSCHEDLER, Laurence V, SPANU, Pietro D, BONCIANI, Giulia, GHEORGHE, Dana M, RUO XU, SURANA, Priyanka, WHIGHAM, Ehren, NETTLETON, Dan, BOGDANOVE, Adam J, WISE, Roger P

“…Obligate biotrophic pathogens of plants must circumvent or counteract defenses to guarantee accommodation inside the host. To do so, they secrete a variety of…”
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Virus-induced inhibition of cardiac pacemaker channel HCN4 triggers bradycardia in human-induced stem cell system by Peischard, Stefan, Möller, Melina, Disse, Paul, Ho, Huyen Tran, Verkerk, Arie O., Strutz-Seebohm, Nathalie, Budde, Thomas, Meuth, Sven G., Schweizer, Patrick A., Morris, Silke, Mücher, Lena, Eisner, Verónica, Thomas, Dierk, Klingel, Karin, Busch, Karin, Seebohm, Guiscard

“…The enterovirus Coxsackievirus B3 (CVB3) is known to be a major source for the development of cardiac dysfunctions like viral myocarditis (VMC) and dilatative…”
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Large-Scale Data Integration Reveals Colocalization of Gene Functional Groups with Meta-QTL for Multiple Disease Resistance in Barley by Schweizer, Patrick, Stein, Nils

“…Race-nonspecific and durable resistance of plant genotypes to major pathogens is highly relevant for yield stability and sustainable crop production but…”
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Augmentation of myocardial I f dysregulates calcium homeostasis and causes adverse cardiac remodeling by Yampolsky, Pessah, Koenen, Michael, Mosqueira, Matias, Geschwill, Pascal, Nauck, Sebastian, Witzenberger, Monika, Seyler, Claudia, Fink, Thomas, Kruska, Mathieu, Bruehl, Claus, Schwoerer, Alexander P, Ehmke, Heimo, Fink, Rainer H A, Draguhn, Andreas, Thomas, Dierk, Katus, Hugo A, Schweizer, Patrick A

“…HCN channels underlie the depolarizing funny current (I ) that contributes importantly to cardiac pacemaking. I is upregulated in failing and infarcted hearts,…”
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The C-terminal HCN4 variant P883R alters channel properties and acts as genetic modifier of atrial fibrillation and structural heart disease by Weigl, Isabel, Geschwill, Pascal, Reiss, Miriam, Bruehl, Claus, Draguhn, Andreas, Koenen, Michael, Sedaghat-Hamedani, Farbod, Meder, Benjamin, Thomas, Dierk, Katus, Hugo A., Schweizer, Patrick A.

“…Atrial fibrillation (AF) is the most frequent sustained arrhythmia and can lead to structural cardiac changes, known as tachycardia-induced cardiomyopathy…”
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Inhibition of cardiac two-pore-domain K+ (K2P) channels--an emerging antiarrhythmic concept by Schmidt, Constanze, Wiedmann, Felix, Schweizer, Patrick A, Katus, Hugo A, Thomas, Dierk

“…Effective and safe pharmacological management of cardiac arrhythmia still constitutes a major clinical challenge. Outward potassium currents mediated by…”
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