Search Results - "SCHWEIKER, S. L"

6-Azasteroids : potent dual inhibitors of human type 1 and 2 steroid 5α-reductase by FRYE, S. V, HAFFNER, C. D, VAN ARNOLD, J, BICKETT, D. M, MOSS, M. L, GAOCHOA TIAN, UNWALLA, R. J, LEE, F. W, TIPPIN, T. K, JMAES, M. K, GRIZZLE, M. K, JAMES, M. K, MALONEY, P. R, SCHUSTER, S. V, MOOK, R. A, DORSEY, G. F, HINER, R. N, BATCHELOR, K. W, BRAMSON, H. N, STUART, J. D, SCHWEIKER, S. L

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Optimizing production of serially diluted compounds and distribution to multiple targets by Harris, Cole O., Schweiker, Stephanie L.

“…The need for a multiple‐target compound selectivity programme led to the establishment of a single robotic system that produces a compound′s serial dilution…”
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Novel pyrazolopyrimidine derivatives as GSK-3 inhibitors by PEAT, Andrew J, BOUCHERON, Joyce A, WANG, Tony Y, ZHOU, Huiqiang Q, THOMSON, Stephen A, DICKERSON, Scott H, GARRIDO, Dulce, MILLS, Wendy, PECKHAM, Jennifer, PREUGSCHAT, Frank, SMALLEY, Terrence, SCHWEIKER, Stephanie L, WILSON, Jayme R

“…A series of [1-aryl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]arylhydrazones were discovered as novel inhibitors glycogen synthase kinase-3 (GSK-3). Based on initial…”
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Synthesis and evaluation of novel heterocyclic inhibitors of GSK-3 by Smalley, Terrence L., Peat, Andrew J., Boucheron, Joyce A., Dickerson, Scott, Garrido, Dulce, Preugschat, Frank, Schweiker, Stephanie L., Thomson, Stephen A., Wang, Tony Y.

“…Novel heterocyclic GSK-3 inhibitors based on a previously described template have been synthesized as a potential treatment for diabetes. Several compounds…”
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Novel GSK-3 inhibitors with improved cellular activity by PEAT, Andrew J, GARRIDO, Dulce, BOUCHERON, Joyce A, SCHWEIKER, Stephanie L, DICKERSON, Scott H, WILSON, Jayme R, WANG, Tony Y, THOMSON, Stephen A

“…A novel series of [1-(1H-benzimidazol-7-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl] arylhydrazones was synthesized and shown to potently inhibit glycogen synthase…”
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4-Acylamino-6-arylfuro[2,3- d]pyrimidines: potent and selective glycogen synthase kinase-3 inhibitors by Maeda, Yutaka, Nakano, Masato, Sato, Hideyuki, Miyazaki, Yasushi, Schweiker, Stephanie L, Smith, Jeffery L, Truesdale, Anne T

“…A novel and potent series of selective GSK-3 inhibitors are described. Some derivatives showed excellent potency in a cellular assay. Modeling studies of a…”
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Structure-activity relationships for inhibition of type 1 and 2 human 5α-reductase and human adrenal 3β-hydroxy-Δ5-steroid dehydrogenase/3-keto-Δ5-steroid isomerase by 6-azaandrost-4-en-3-ones : optimization of the C17 substituent by FRYE, S. V, HAFFNER, C. D, SCHWEIKER, S. L, VAN ARNOLD, J, BICKETT, D. M, MOSS, M. L, GAOCHOA TIAN, LEE, F. W, TIPPIN, T. K, JAMES, M. K, GRIZZLE, M. K, LONG, J. E, MALONEY, P. R, CROOM, D. K, HINER, R. N, DORSEY, G. F, NOE, R. A, UNWALLA, R. J, BATCHELOR, K. W, BRAMSON, H. N, STUART, J. D

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6-Azasteroids : structure-activity relationships for inhibition of type 1 and 2 human 5α-reductase and human adrenal 3β-hydroxy-Δ5-steroid dehydrogenase/3-keto-Δ5-steroid isomerase by FRYE, S. V, HAFFNER, C. D, BATCHELOR, K. W, BRAMSON, H. N, STUART, J. D, SCHWEIKER, S. L, VAN ARNOLD, J, CROOM, S, BICKETT, D. M, MOSS, M. L, TIAN, G, UNWALLA, R. J, MALONEY, P. R, LEE, F. W, TIPPIN, T. K, JAMES, M. K, GRIZZLE, M. K, LONG, J. E, SCHUSTER, S. V, MOOK, R. A, DORSEY, G. F, HINER, R. N, CRIBBS, C. M, WHEELER, T. N, RAY, J. A, ANDREWS, R. C

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Optimizing production of serially diluted compounds and distribution to multiple targets by HARRIS, Cole O, SCHWEIKER, Stephanie L

“…The need for a multiple-target compound selectivity programme led to the establishment of a single robotic system that produces a compound's serial dilution…”
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