Search Results - "SCHWARZMAN, A. L"

Screening for LRRK2 mutations in patients with Parkinson's disease in Russia: identification of a novel LRRK2 variant by Pchelina, S. N., Yakimovskii, A. F., Emelyanov, A. K., Ivanova, O. N., Schwarzman, A. L., Singleton, A. B.

“…Background and purpose:  Mutations in LRRK2, encoding leucine‐rich repeat kinase 2 (or Dardarin), cause autosomal dominant Parkinson's disease (AdPD) and are…”
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Dendrimer D5 is a Vector for Peptide Transport to Brain Cells by Sarantseva, S. V, Bolshakova, O. I, Timoshenko, S. I, Kolobov, A. A, Schwarzman, A. L

“…Dendrimers are a new class of nonviral vectors for gene or drug transport. Dendrimer capacity to penetrate through the blood-brain barrier remaines little…”
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Modern genetic approaches to searching for targets for medicinal preparations by Sarantseva, S. V, Schwarzman, A. L

“…In spite of a vast number of drug preparations used in medicine, advances in treating most socially important human diseases remain modest. Historically, many…”
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Transthyretin Sequesters Amyloid β Protein and Prevents Amyloid Formation by Schwarzman, Alexander L., Gregori, Luisa, Vitek, Michael P., Lyubski, Sergey, Strittmatter, Warren J., Enghilde, Jan J., Bhasin, Ramaninder, Silverman, Josh, Weisgraber, Karl H., Coyle, Patricia K., Zagorski, Michael G., Talafous, Joseph, Eisenberg, Moises, Saunders, Ann M., Roses, Allen D., Goldgaber, Dmitry

“…The cardinal pathological features of Alzheimer disease are depositions of aggregated amyloid β protein (Aβ) in the brain and cerebrovasculature. However, the…”
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Transmission of pathogenic protein aggregates in Alzheimer’s disease by Schwarzman, A. L., Sarantseva, S. V.

“…Deposits of amyloid peptide Aβ and intracellular aggregates of hyperphosphorylated tau protein in the brain of patients are major neuropathological features of…”
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Prion Properties of Alpha-Synuclein by Schwarzman, A. L., Senkevich, K. A., Emelyanov, A. K., Pchelina, S. N.

“…— The prion properties of alpha-synuclein, a key aggregating protein involved in the pathogenesis of so-called synucleinopathies, including Parkinson’s disease…”
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High Level of α-Synuclein mRNA in Peripheral Lymphocytes of Patients with Alcohol Dependence Syndrome by Taraskina, A. E, Filimonov, V. A, Kozlovskaya, Yu. A, Morozova, M. N, Gaschin, D. V, Schwarzman, A. L

“…The content of mRNA for α-synuclein (a key protein of the dopaminergic system) was elevated in the peripheral lymphocytes of patients with alcohol dependence…”
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Reduced Content of α-Synuclein in Peripheral Blood Leukocytes of Patients with LRRK2-Associated Parkinson’s Disease by Pchelina, S. N., Emelyanov, A. K., Yakimovskii, A. F., Miller, D. W., Shabalina, I. G., Drozdova, A. S., Schwarzman, A. L.

“…Measurement of α-synuclein level in the peripheral blood was proposed as a diagnostic test for Parkinson’s disease. However, the results of these studies…”
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Role of the ABC transporters A1 and G1, key reverse cholesterol transport proteins, in atherosclerosis by Demina, E. P., Miroshnikova, V. V., Schwarzman, A. L.

“…Atherosclerosis is one of the most common causes of death worldwide. Epidemiology studies firmly established an inverse relationship between atherogenesis and…”
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Studying the pathogenesis of Alzheimer's disease in a Drosophila melanogaster model: Human APP overexpression in the brain of transgenic flies leads to deficit of the synaptic protein synaptotagmin by Sarantseva, S. V, Bolshakova, O. I, Timoshenko, S. I, Rodin, D. I, Vitek, M, Schwarzman, A. L

“…Alzheimer's disease (AD) is a progressive neurodegenerative disease whose main pathomorphological sign is synapse degeneration in the cortex and hippocampus…”
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Endogenous Presenilin 1 Redistributes to the Surface of Lamellipodia upon Adhesion of Jurkat Cells to a Collagen Matrix by Schwarzman, Alexander L., Singh, Nandita, Tsiper, Maria, Gregori, Luisa, Dranovsky, Alex, Vitek, Michael P., Glabe, Charles G., St. George-Hyslop, Peter H., Goldgaber, Dmitry

“…Most familial early-onset Alzheimer's disease cases are caused by mutations in the presenilin 1 (PS1) gene. Subcellular localization of the endogenous PS1 is…”
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Expression of human amyloid precursor protein in Drosophila melanogaster nerve cells causes a decrease in presynaptic gene mRNA levels by Rodin, D I, Schwarzman, A L, Sarantseva, S V

“…Amyloid precursor protein (APP) is a key player in Alzheimer's disease. The proteolytic cleavage of APP results in various short peptide fragments including…”
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Genetic variants of platelet ADP receptor P2Y12 associated with changed platelet functional activity and development of cardiovascular diseases by Sirotkina, O. V, Zabotina, A. M, Berkovich, O. A, Bazhenova, E. A, Vavilova, T. V, Schwarzman, A. L

“…The key role in platelet aggregation is played by the platelet ADP receptor P2Y12, which is the target for antiaggregant drugs, clopidogrel and ticlopidine. At…”
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Protein transduction domain peptide mediates delivery to the brain via the blood-brain barrier in Drosophila melanogaster by Sarantseva, S. V., Bolshakova, O. I., Timoshenko, S. I., Kolobov, A. A., Vitek, M. P., Schwarzman, A. L.

“…The phenomenon of protein transduction represents internalization of short peptides known as protein transduction domains (PTD) by cells. It is widely used in…”
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Association of polymorphisms in apolipoprotein A-I gene with plasma lipid profile in population of Saint-Petersburg by Miroshnikova, V. V., Panteleeva, A. A., Pchelina, S. N., Schwarzman, A. L.

“…Apolipoprotein A-I is a key structure protein of antiatherogenic high density lipoproteins (HDL). The aim of the study was to investigate the relationship…”
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Human APP gene expression in nerve cells of Drosophila melanogaster causes alteration of synaptoptagmin 1 mRNA level by Sarantseva, S. V., Rodin, D. I., Schwarzman, A. L.

“…According to the amyloid cascade hypothesis, hereditary forms of Alzheimer's disease (AD), caused by mutations in the amyloid peptide precursor (APP) gene,…”
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The study of the neuroprotective activity of the apolipoprotein E peptide mimetic Cog1410 in transgenic strains of Drosophila melanogaster by Latypova, E. M., Timoshenko, S. I., Kislik, G. A., Vitek, M. P., Schwarzman, A. L., Sarantseva, S. V.

“…The neuroprotective activity of peptide mimetic of apolipoprotein E (apoE) Cog1410, containing the amino acid sequence of the apoE receptor-binding domain, has…”
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ABCA1 gene expression in peripheral blood lymphocytes and macrophages in patients with atherosclerosis by Demina, E. P., Miroshnikova, V. V., Rodygina, T. I., Kurianov, P. S., Vinogradov, A. G., Denisenko, A. D., Schwarzman, A. L.

“…ABCA1 transporter is known to play an important role in cholesterol transport from peripheral tissues. However, its contribution to atherosclerosis development…”
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Ceruloplasmin gene defect associated with epilepsy in EL mice by Garey, Caroline E, Schwarzman, Alexander L, Rise, Matthew L, Seyfried, Thomas N

“…Epilepsy is a dominant trait in EL mice, a model for human complex partial seizures. We recently mapped the major gene, El-1, to chromosome 9 near the…”
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De novo mutation within the intron-exon junction in the PiZ allele of the alpha-1-antitrypsin gene by SCHWARZMAN, A. L, KOWALSKA, A, RUJNER, J, VLASOV, M. S, GAITSKHOKI, V. S

“…A proband homozygous for the PiZ allele of the alpha-1-antitrypsin gene was found to be a heterozygous carrier of the additional nucleotide substitution (C-T)…”
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