Search Results - "SCHWARZ, Yvonne"
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TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses
Published in PLoS biology (01-09-2019)“…Transient receptor potential (TRP) proteins form Ca2+-permeable, nonselective cation channels, but their role in neuronal Ca2+ homeostasis is elusive. In the…”
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2
Human gut bacterial communities are altered by addition of cruciferous vegetables to a controlled fruit- and vegetable-free diet
Published in The Journal of nutrition (01-09-2009)“…In the human gut, commensal bacteria metabolize food components that typically serve as energy sources. These components have the potential to influence gut…”
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3
Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory
Published in The EMBO journal (15-09-2017)“…Canonical transient receptor potential (TRPC) channels influence various neuronal functions. Using quantitative high‐resolution mass spectrometry, we…”
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4
A synaptic temperature sensor for body cooling
Published in Neuron (Cambridge, Mass.) (20-10-2021)“…Deep brain temperature detection by hypothalamic warm-sensitive neurons (WSNs) has been proposed to provide feedback information relevant for thermoregulation…”
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5
SNARE force synchronizes synaptic vesicle fusion and controls the kinetics of quantal synaptic transmission
Published in The Journal of neuroscience (04-08-2010)“…Neuronal communication relies on rapid and discrete intercellular signaling but neither the molecular mechanisms of the exocytotic machinery that define the…”
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Synergistic actions of v-SNARE transmembrane domains and membrane-curvature modifying lipids in neurotransmitter release
Published in eLife (11-05-2020)“…Vesicle fusion is mediated by assembly of SNARE proteins between opposing membranes. While previous work suggested an active role of SNARE transmembrane…”
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v-SNARE transmembrane domains function as catalysts for vesicle fusion
Published in eLife (25-06-2016)“…Vesicle fusion is mediated by an assembly of SNARE proteins between opposing membranes, but it is unknown whether transmembrane domains (TMDs) of SNARE…”
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8
Reliability of Serum Biomarkers of Inflammation from Repeated Measures in Healthy Individuals
Published in Cancer epidemiology, biomarkers & prevention (01-07-2012)“…Biomarkers of low-grade systemic inflammation are used to study the associations of inflammation with chronic diseases, including cancer. However, relatively…”
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9
A mechanism for exocytotic arrest by the Complexin C-terminus
Published in eLife (25-07-2018)“…ComplexinII (CpxII) inhibits non-synchronized vesicle fusion, but the underlying mechanisms have remained unclear. Here, we provide evidence that the far…”
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10
Membrane-proximal tryptophans of synaptobrevin II stabilize priming of secretory vesicles
Published in The Journal of neuroscience (07-11-2012)“…Trans-soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE) complexes formed between the SNARE motifs of synaptobrevin II,…”
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CYP1A2, GSTM1, and GSTT1 Polymorphisms and Diet Effects on CYP1A2 Activity in a Crossover Feeding Trial
Published in Cancer epidemiology, biomarkers & prevention (01-11-2009)“…Cytochrome P-450 1A2 (CYP1A2) is a biotransformation enzyme that activates several procarcinogens. CYP1A2 is induced by cruciferous and inhibited by apiaceous…”
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12
Modulation of Human Serum Glutathione S-Transferase A1/2 Concentration by Cruciferous Vegetables in a Controlled Feeding Study Is Influenced by GSTM1 and GSTT1 Genotypes
Published in Cancer epidemiology, biomarkers & prevention (01-11-2009)“…Glutathione S -transferases (GST) detoxify a wide range of carcinogens. Isothiocyanates (ITC), from cruciferous vegetables, are substrates for and inducers of…”
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13
UGT1A6 polymorphism and salicylic acid glucuronidation following aspirin
Published in Pharmacogenetics and genomics (01-08-2007)“…OBJECTIVESIn vivo, aspirin (acetylsalicylic acid) is rapidly deacetylated to form salicylic acid, which then undergoes primary or secondary glucuronidation…”
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Determinants of Aspirin Metabolism in Healthy Men and Women: Effects of Dietary Inducers of UDP-Glucuronosyltransferases
Published in Journal of nutrigenetics and nutrigenomics (01-01-2011)“…Background/Aims: Interindividual variation in aspirin (ASA) metabolism is attributed to concomitant use of drugs or alcohol, urine pH, ethnicity, sex, and…”
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15
Astrocytes control synaptic strength by two distinct v-SNARE-dependent release pathways
Published in Nature neuroscience (01-11-2017)“…The mechanisms of gliotransmitter release and their impact on neuronal signaling have remained largely elusive. The authors describe two functionally…”
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Serum β-Glucuronidase Activity in Response to Fruit and Vegetable Supplementation: A Controlled Feeding Study
Published in Cancer epidemiology, biomarkers & prevention (01-07-2008)“…Background: Fruit and vegetable (F&V) intake may lower the risk of some cancers. One hypothesized, but understudied, chemopreventive mechanism is that plant…”
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17
Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes
Published in Neuron (Cambridge, Mass.) (21-12-2022)“…In the mammalian brain TRPC channels, a family of Ca2+-permeable cation channels, are involved in a variety of processes from neuronal growth and synapse…”
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Dietary biomarker evaluation in a controlled feeding study in women from the Women's Health Initiative cohort
Published in The American journal of clinical nutrition (01-02-2017)“…Controlled human feeding studies are necessary for robust nutritional biomarker development and validation. Previous feeding studies have typically evaluated…”
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Large scale, unbiased analysis of elementary calcium signaling events in cardiac myocytes
Published in Journal of molecular and cellular cardiology (01-10-2019)“…The identification of spatiotemporally restricted Ca2+ signals, Ca2+ sparks, was instrumental for our understanding of cardiac Ca2+ homeostasis. High-speed 2D…”
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20
A short isoform of STIM1 confers frequency-dependent synaptic enhancement
Published in Cell reports (Cambridge) (16-03-2021)“…Store-operated Ca2+-entry (SOCE) regulates basal and receptor-triggered Ca2+ signaling with STIM proteins sensing the endoplasmic reticulum (ER) Ca2+ content…”
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