Search Results - "SCHWARZ, Sylvia"

A phase 1b study of AFM13 in combination with pembrolizumab in patients with relapsed or refractory Hodgkin lymphoma by Bartlett, Nancy L., Herrera, Alex F., Domingo-Domenech, Eva, Mehta, Amitkumar, Forero-Torres, Andres, Garcia-Sanz, Ramon, Armand, Philippe, Devata, Sumana, Izquierdo, Antonia Rodriguez, Lossos, Izidore S., Reeder, Craig, Sher, Taimur, Chen, Robert, Schwarz, Sylvia E., Alland, Leila, Strassz, Andras, Prier, Kim, Choe-Juliak, Cassandra, Ansell, Stephen M.

“…In relapsed/refractory Hodgkin lymphoma (R/R HL), immunotherapies such as the anti-programmed death-1 inhibitor pembrolizumab have demonstrated efficacy as…”
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A novel orf virus vector-based COVID-19 booster vaccine shows cross-neutralizing activity in the absence of anti-vector neutralizing immunity by Klinkardt, Ute, Schunk, Mirjam, Ervin, John, Schindler, Christoph, Sugimoto, Danny, Rankin, Bruce, Amann, Ralf, Monti, Martina, Kutschenko, Anna, Schumacher, Carsten, Huber, Kristina, Zeder, Andreas, Heikkila, Nelli, Didierlaurent, Arnaud M, Schwarz, Sylvia E, Derouazi, Madiha

“…Next-generation COVID-19 vaccines are being developed to expand the breadth of coverage against existing and future variants and to extend the duration of…”
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Safety of AFM11 in the treatment of patients with B-cell malignancies: findings from two phase 1 studies by Topp, Max, Dlugosz-Danecka, Monika, Skotnicki, Aleksander B, Salogub, Galina, Viardot, Andreas, Klein, Andreas K, Hess, Georg, Michel, Christian S, Grosicki, Sebastian, Gural, Alex, Schwarz, Sylvia E, Pietzko, Kerstin, Gärtner, Ulrike, Strassz, András, Alland, Leila, Mayer, Jiri

“…The prognosis for patients with relapsed and/or refractory (R/R) non-Hodgkin's lymphoma (NHL) or acute lymphoblastic leukaemia (ALL) remains poor, with…”
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Role of Predicted Metalloprotease Motif of Jab1/Csn5 in Cleavage of Nedd8 from Cul1 by Cope, Gregory A., Greg S. B. Suh, Aravind, L., Schwarz, Sylvia E., Zipursky, S. Lawrence, Koonin, Eugene V., Deshaies, Raymond J.

“…COP9 signalosome (CSN) cleaves the ubiquitin-like protein Nedd8 from the Cul1 subunit of SCF ubiquitin ligases. The Jab1/MPN domain metalloenzyme (JAMM) motif…”
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Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1 by Gostissa, Monica, Hengstermann, Arnd, Fogal, Valentina, Sandy, Peter, Schwarz, Sylvia E., Scheffner, Martin, Del Sal, Giannino

“…The growth‐suppressive properties of p53 are controlled by posttranslational modifications and by regulation of its turnover rate. Here we show that p53 can be…”
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The ubiquitin-like proteins SMT3 and SUMO-1 are conjugated by the UBC9 E2 enzyme by Schwarz, S.E, Matuschewski, K, Liakopoulos, D, Scheffner, M, Jentsch, S

“…The ubiquitin-like protein SMT3 from Saccharomyces cerevisiae and SUMO-1, its mammalian homolog, can be covalently attached to other proteins…”
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Cloning of Human Ubiquitin-conjugating Enzymes UbcH6 and UbcH7 (E2-F1) and Characterization of Their Interaction with E6-AP and RSP5 () by Nuber, Ulrike, Schwarz, Sylvia, Kaiser, Peter, Schneider, Rainer, Scheffner, Martin

“…E6-AP, a 100-kDa cellular protein, was originally identified through its interaction with the E6 protein of the oncogenic human papillomavirus types 16 and 18…”
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Hemodynamic and catecholamine stress responses to insertion of the combitube®, laryngeal mask airway or tracheal intubation by OCZENSKI, W, KRENN, H, DAHABA, A. A, BINDER, M, EL-SCHAHAWI-KIENZL, I, JELLINEK, H, SCHWARZ, S, FITZGERALD, R. D

“…In a prospective, randomized, and controlled trial, we compared the stress responses after insertion of the Combitube (CT; Kendall-Sheridan Catheter Corp.,…”
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HLA-DR as a marker for increased risk for systemic inflammation and septic complications after cardiac surgery by Oczenski, Wolfgang, Krenn, Herbert, Jilch, Ruth, Watzka, Herbert, Waldenberger, Ferdinand, K ller, Ursula, Schwarz, Sylvia, Fitzgerald, Robert D.

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Characterization of Human hect Domain Family Members and Their Interaction with UbcH5 and UbcH7 by Schwarz, Sylvia E., Rosa, José L., Scheffner, Martin

“…The hect domain protein family was originally identified by sequence similarity of its members to the C-terminal region of E6-AP, an E3 ubiquitin-protein…”
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ISRAEL DENYING ENTRY TO TLAIB, OMAR REVEALS LARGER ISSUE by Angell, Eric, Schwarz, Sylvia

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Vacuum-assisted closure for the treatment of cervical and mediastinal necrotizing fasciitis by Oczenski, Wolfgang, Waldenberger, Ferdinand, Nehrer, Greta, Kneifel, Werner, Swoboda, Herwig, Schwarz, Sylvia, Fitzgerald, Robert D

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A phase II open-label multicenter study to assess the efficacy and safety of AFM13 in patients with relapsed or refractory CD30-positive peripheral T-cell lymphoma or transformed mycosis fungoides: The REDIRECT study design and rationale by Choe-Juliak, Cassandra, Alexis, Karenza M., Schwarz, Sylvia, Garcia, Linta, Sawas, Ahmed

“…Abstract only TPS3148 Background: AFM13 is a tetravalent, bispecific (anti-CD30/anti-CD16A) recombinant antibody being developed for the treatment of…”
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A Phase 1 Study Investigating AFM11 in Patients with Relapsed/Refractory B Cell Precursor Acute Lymphoblastic Leukemia: Preliminary Results by Salogub, Galina, Mayer, Jiri, Folber, Frantisek, Grosicki, Sebastian, Skotnicki, Aleksander B, Prochwicz, Anna, Myasnikov, Alexander, Gural, Alexander, Schoenborn-Kellenberger, Oliver, Brindley, Charlie, Knackmuss, Stefan, Schwarz, Sylvia, Schmich, Sandra, Choe-Juliak, Cassandra, Strassz, Andras, Alland, Leila, Doubek, Michael

“…Background AFM11 is a bispecific, tetravalent T cell-engaging antibody construct binding to CD19 on B cell origin malignant cells such as B-precursor acute…”
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A Phase 1b Study Investigating the Combination of the Tetravalent Bispecific NK Cell Engager AFM13 and Pembrolizumab in Patients with Relapsed/Refractory Hodgkin Lymphoma after Brentuximab Vedotin Failure: Updated Safety and Efficacy Data by Bartlett, Nancy L., Chen, Robert W., Domingo-Domenech, Eva, Forero-Torres, Andres, Garcia-Sanz, Ramon, Armand, Philippe, Devata, Sumana, Rodriguez Izquierdo, Antonia, Lossos, Izidore S., Reeder, Craig B., Sher, Taimur, Choe-Juliak, Cassandra, Prier, Kim, Schwarz, Sylvia, Strassz, Andras, Alland, Leila, Ansell, Stephen M.

“…Background AFM13 is a bispecific, tetravalent NK cell-engaging antibody construct binding to CD30 on CD30+ tumor cells and CD16A on NK cells. By engaging…”
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CobraPLUS and Cookgas air-Q versus Fastrach for blind endotracheal intubation: a randomised controlled trial by Erlacher, Wolfgang, Tiefenbrunner, Heide, Kästenbauer, Thomas, Schwarz, Sylvia, Fitzgerald, Robert D

“…BACKGROUND AND OBJECTIVECobraPLUS and Cookgas air-Q are supraglottic airways expected to allow safe ventilation as well as reliable blind intubation. In a…”
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The ubiquitin‐protein ligase E6‐associated protein (E6‐AP) serves as its own substrate by Nuber, Ulrike, Schwarz, Sylvia E., Scheffner, Martin

“…Recognition of substrate proteins by the ubiquitin‐conjugation system is a highly specific and regulated event and involves the action of ubiquitin‐conjugating…”
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Recruitment maneuvers after a positive end-expiratory pressure trial do not induce sustained effects in early adult respiratory distress syndrome by OCZENSKI, Wolfgang, HÖRMANN, Christoph, KELLER, Christian, LORENZL, Norbert, KEPKA, Anton, SCHWARZ, Sylvia, FITZGERALD, Robert D

“…Recruitment maneuvers performed in early adult respiratory distress syndrome remain a matter of dispute in patients ventilated with low tidal volumes and high…”
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HLA-DR as a marker for increased risk for systemic inflammation and septic complications after cardiac surgery by Oczenski, Wolfgang, Krenn, Herbert, Jilch, Ruth, Watzka, Herbert, Waldenberger, Ferdinand, Köller, Ursula, Schwarz, Sylvia, Fitzgerald, Robert D

“…This study investigated the predictive value of a decrease in monocyte HLA-DR expression as an early marker for postoperative SIRS and septic complications. We…”
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Recruitment maneuvers during prone positioning in patients with acute respiratory distress syndrome by Oczenski, Wolfgang, Hörmann, Christoph, Keller, Christian, Lorenzl, Norbert, Kepka, Anton, Schwarz, Sylvia, Fitzgerald, Robert D

“…OBJECTIVE:To evaluate the interaction of recruitment maneuvers and prone positioning on gas exchange and venous admixture in patients with early extrapulmonary…”
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