Search Results - "SCHWARTZ, Peter J"

1970–2020: 50 years of research on the long QT syndrome—from almost zero knowledge to precision medicine by Schwartz, Peter J

“…Abstract To those of us involved in clinical research it seldom happens to begin working on a rather obscure disease, still largely unexplored, and to follow…”
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QTc behavior during exercise and genetic testing for the long-QT syndrome by Schwartz, Peter J, Crotti, Lia

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Cardiac sympathetic denervation to prevent life-threatening arrhythmias by Schwartz, Peter J.

“…Key Points After initial reports of the successful treatment of patients with angina, left cardiac sympathetic denervation (LCSD) entered clinical practice in…”
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Precision Medicine and cardiac channelopathies: when dreams meet reality by Gnecchi, Massimiliano, Sala, Luca, Schwartz, Peter J

“…Abstract Precision Medicine (PM) is an innovative approach that, by relying on large populations’ datasets, patients’ genetics and characteristics, and…”
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Impact of Genetics on the Clinical Management of Channelopathies by Schwartz, Peter J., MD, Ackerman, Michael J., MD, PhD, George, Alfred L., MD, Wilde, Arthur A.M., MD, PhD

“…There are few areas in cardiology in which the impact of genetics and genetic testing on clinical management has been as great as in cardiac channelopathies,…”
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From patient-specific induced pluripotent stem cells to clinical translation in long QT syndrome Type 2 by Schwartz, Peter J, Gnecchi, Massimiliano, Dagradi, Federica, Castelletti, Silvia, Parati, Gianfranco, Spazzolini, Carla, Sala, Luca, Crotti, Lia

“…Abstract Aims Having shown that Lumacaftor rescued the hERG trafficking defect in the induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) of two…”
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Exercise Training-Induced Repolarization Abnormalities Masquerading as Congenital Long QT Syndrome by Dagradi, Federica, Spazzolini, Carla, Castelletti, Silvia, Pedrazzini, Matteo, Kotta, Maria-Christina, Crotti, Lia, Schwartz, Peter J.

“…BACKGROUND:The diagnosis of long QT syndrome (LQTS) is rather straightforward. We were surprised by realizing that, despite long-standing experience, we were…”
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Identification of a targeted and testable antiarrhythmic therapy for long-QT syndrome type 2 using a patient-specific cellular model by Mehta, Ashish, Ramachandra, Chrishan J A, Singh, Pritpal, Chitre, Anuja, Lua, Chong Hui, Mura, Manuela, Crotti, Lia, Wong, Philip, Schwartz, Peter J, Gnecchi, Massimiliano, Shim, Winston

“…Abstract Aims Loss-of-function mutations in the hERG gene causes long-QT syndrome type 2 (LQT2), a condition associated with reduced IKr current. Four…”
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European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) Expert Consensus Statement on the State of Genetic Testing for Cardiac Diseases by Wilde, Arthur A.M., Semsarian, Christopher, Márquez, Manlio F., Sepehri Shamloo, Alireza, Ackerman, Michael J., Ashley, Euan A., Sternick, Eduardo Back, Barajas-Martinez, Héctor, Behr, Elijah R., Bezzina, Connie R., Breckpot, Jeroen, Charron, Philippe, Chockalingam, Priya, Crotti, Lia, Gollob, Michael H., Lubitz, Steven, Makita, Naomasa, Ohno, Seiko, Ortiz-Genga, Martín, Sacilotto, Luciana, Schulze-Bahr, Eric, Shimizu, Wataru, Sotoodehnia, Nona, Tadros, Rafik, Ware, James S., Winlaw, David S., Kaufman, Elizabeth S., Aiba, Takeshi, Bollmann, Andreas, Choi, Jong-Il, Dalal, Aarti, Darrieux, Francisco, Giudicessi, John, Guerchicoff, Mariana, Hong, Kui, Krahn, Andrew D., MacIntyre, Ciorsti, Mackall, Judith A., Mont, Lluís, Napolitano, Carlo, Ochoa, Juan Pablo, Peichl, Petr, Pereira, Alexandre C., Schwartz, Peter J., Skinner, Jon, Stellbrink, Christoph, Tfelt-Hansen, Jacob, Deneke, Thomas

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Vagus Nerve Stimulation for the Treatment of Heart Failure: The INOVATE-HF Trial by Gold, Michael R., MD, PhD, Van Veldhuisen, Dirk J., MD, PhD, Hauptman, Paul J., MD, Borggrefe, Martin, MD, Kubo, Spencer H., MD, Lieberman, Randy A., MD, Milasinovic, Goran, MD, Berman, Brett J., MD, Djordjevic, Sanja, MD, Neelagaru, Suresh, MD, Schwartz, Peter J., MD, Starling, Randall C., MDs, MPH, Mann, Douglas L., MD

“…Abstract Background Heart Failure (HF) is increasing in prevalence and is a major cause of morbidity and mortality, despite advances in medical and device…”
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Calmodulin mutations and life-threatening cardiac arrhythmias: insights from the International Calmodulinopathy Registry by Crotti, Lia, Spazzolini, Carla, Tester, David J, Ghidoni, Alice, Baruteau, Alban-Elouen, Beckmann, Britt-Maria, Behr, Elijah R, Bennett, Jeffrey S, Bezzina, Connie R, Bhuiyan, Zahurul A, Celiker, Alpay, Cerrone, Marina, Dagradi, Federica, De Ferrari, Gaetano M, Etheridge, Susan P, Fatah, Meena, Garcia-Pavia, Pablo, Al-Ghamdi, Saleh, Hamilton, Robert M, Al-Hassnan, Zuhair N, Horie, Minoru, Jimenez-Jaimez, Juan, Kanter, Ronald J, Kaski, Juan P, Kotta, Maria-Christina, Lahrouchi, Najim, Makita, Naomasa, Norrish, Gabrielle, Odland, Hans H, Ohno, Seiko, Papagiannis, John, Parati, Gianfranco, Sekarski, Nicole, Tveten, Kristian, Vatta, Matteo, Webster, Gregory, Wilde, Arthur A M, Wojciak, Julianne, George, Alfred L, Ackerman, Michael J, Schwartz, Peter J

“…Abstract Aims Calmodulinopathies are rare life-threatening arrhythmia syndromes which affect mostly young individuals and are, caused by mutations in any of…”
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Clinical neurocardiology defining the value of neuroscience‐based cardiovascular therapeutics by Shivkumar, Kalyanam, Ajijola, Olujimi A., Anand, Inder, Armour, J. Andrew, Chen, Peng‐Sheng, Esler, Murray, Ferrari, Gaetano M., Fishbein, Michael C., Goldberger, Jeffrey J., Harper, Ronald M., Joyner, Michael J., Khalsa, Sahib S., Kumar, Rajesh, Lane, Richard, Mahajan, Aman, Po, Sunny, Schwartz, Peter J., Somers, Virend K., Valderrabano, Miguel, Vaseghi, Marmar, Zipes, Douglas P.

“…The autonomic nervous system regulates all aspects of normal cardiac function, and is recognized to play a critical role in the pathophysiology of many…”
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Prevalence of the Congenital Long-QT Syndrome by SCHWARTZ, Peter J, STRAMBA-BADIALE, Marco, MOSCA, Fabio, NESPOLI, Luigi, RIMINI, Alessandro, ROSATI, Enrico, SALICE, Patrizia, SPAZZOLINI, Carla, CROTTI, Lia, PEDRAZZINI, Matteo, BESANA, Alessandra, BOSI, Giuliano, GABBARINI, Fulvio, GOULENE, Karine, INSOLIA, Roberto, MANNARINO, Savina

“…The prevalence of genetic arrhythmogenic diseases is unknown. For the long-QT syndrome (LQTS), figures ranging from 1:20 000 to 1:5000 were published, but none…”
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The genetics underlying acquired long QT syndrome: impact for genetic screening by Itoh, Hideki, Crotti, Lia, Aiba, Takeshi, Spazzolini, Carla, Denjoy, Isabelle, Fressart, Véronique, Hayashi, Kenshi, Nakajima, Tadashi, Ohno, Seiko, Makiyama, Takeru, Wu, Jie, Hasegawa, Kanae, Mastantuono, Elisa, Dagradi, Federica, Pedrazzini, Matteo, Yamagishi, Masakazu, Berthet, Myriam, Murakami, Yoshitaka, Shimizu, Wataru, Guicheney, Pascale, Schwartz, Peter J, Horie, Minoru

“…Acquired long QT syndrome (aLQTS) exhibits QT prolongation and Torsades de Pointes ventricular tachycardia triggered by drugs, hypokalaemia, or bradycardia…”
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Autonomic Control of the Heart and Its Clinical Impact. A Personal Perspective by La Rovere, Maria Teresa, Porta, Alberto, Schwartz, Peter J.

“…This essay covers several aspects of the autonomic control of the heart, all relevant to cardiovascular pathophysiology with a direct impact on clinical…”
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Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes by Rocchetti, Marcella, Sala, Luca, Dreizehnter, Lisa, Crotti, Lia, Sinnecker, Daniel, Mura, Manuela, Pane, Luna Simona, Altomare, Claudia, Torre, Eleonora, Mostacciuolo, Gaspare, Severi, Stefano, Porta, Alberto, De Ferrari, Gaetano M, George, Jr, Alfred L, Schwartz, Peter J, Gnecchi, Massimiliano, Moretti, Alessandra, Zaza, Antonio

“…Calmodulin (CaM) is a small protein, encoded by three genes (CALM1-3), exerting multiple Ca2+-dependent modulatory roles. A mutation (F142L) affecting only one…”
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Chronic vagus nerve stimulation: a new and promising therapeutic approach for chronic heart failure by DE FERRARI, Gaetano M, CRIJNS, Harry J. G. M, RASPOPOVIC, Srdjan, KLEIN, Helmut, SWEDBERG, Karl, SCHWARTZ, Peter J, BORGGREFE, Martin, MILASINOVIC, Goran, SMID, Jan, ZABEL, Markus, GAVAZZI, Antonello, SANZO, Antonio, DENNERT, Robert, KUSCHYK, Juergen

“…In chronic heart failure (CHF), reduced vagal activity correlates with increased mortality and acute decompensation. Experimentally, chronic vagus nerve…”
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Implantable cardioverter-defibrillator use in catecholaminergic polymorphic ventricular tachycardia: A systematic review by Roston, Thomas M., Jones, Karolina, Hawkins, Nathaniel M., Bos, J. Martijn, Schwartz, Peter J., Perry, Frances, Ackerman, Michael J., Laksman, Zachary W.M., Kaul, Padma, Lieve, Krystien V.V., Atallah, Joseph, Krahn, Andrew D., Sanatani, Shubhayan

“…The implantable cardioverter-defibrillator (ICD) may be associated with a high risk of complications in patients with catecholaminergic polymorphic ventricular…”
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The congenital long QT syndromes from genotype to phenotype: clinical implications by SCHWARTZ, PETER J.

“… The long QT syndrome (LQTS) is a genetic disorder responsible for many sudden deaths before age 20. The identification of several LQTS genes, all encoding…”
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Autonomic Control of Heart Rate and QT Interval Variability Influences Arrhythmic Risk in Long QT Syndrome Type 1 by Porta, Alberto, MS, PhD, Girardengo, Giulia, MD, Bari, Vlasta, MS, George, Alfred L., MD, Brink, Paul A., MD, PhD, Goosen, Althea, RN, Crotti, Lia, MD, PhD, Schwartz, Peter J., MD

“…Abstract Background A puzzling feature of the long QT syndrome (LQTS) is that family members carrying the same mutation often have divergent symptoms and…”
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