Search Results - "SCHWARTZ, Benjamin D"

Vamorolone trial in Duchenne muscular dystrophy shows dose-related improvement of muscle function by Hoffman, Eric P, Schwartz, Benjamin D, Mengle-Gaw, Laurel J, Smith, Edward C, Castro, Diana, Mah, Jean K, McDonald, Craig M, Kuntz, Nancy L, Finkel, Richard S, Guglieri, Michela, Bushby, Katharine, Tulinius, Mar, Nevo, Yoram, Ryan, Monique M, Webster, Richard, Smith, Andrea L, Morgenroth, Lauren P, Arrieta, Adrienne, Shimony, Maya, Siener, Catherine, Jaros, Mark, Shale, Phil, McCall, John M, Nagaraju, Kanneboyina, van den Anker, John, Conklin, Laurie S, Cnaan, Avital, Gordish-Dressman, Heather, Damsker, Jesse M, Clemens, Paula R

“…OBJECTIVETo study vamorolone, a first-in-class steroidal anti-inflammatory drug, in Duchenne muscular dystrophy (DMD). METHODSAn open-label,…”
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Efficacy and safety of vamorolone in Duchenne muscular dystrophy: An 18-month interim analysis of a non-randomized open-label extension study by Smith, Edward C., Conklin, Laurie S., Hoffman, Eric P., Clemens, Paula R., Mah, Jean K., Finkel, Richard S., Guglieri, Michela, Tulinius, Mar, Nevo, Yoram, Ryan, Monique M., Webster, Richard, Castro, Diana, Kuntz, Nancy L., Kerchner, Laurie, Morgenroth, Lauren P., Arrieta, Adrienne, Shimony, Maya, Jaros, Mark, Shale, Phil, Gordish-Dressman, Heather, Hagerty, Laura, Dang, Utkarsh J., Damsker, Jesse M., Schwartz, Benjamin D., Mengle-Gaw, Laurel J., McDonald, Craig M.

“…The differential mechanism of action of vamorolone compared to traditional corticosteroid anti-inflammatory drugs is attributed to the loss of gene…”
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Phase IIa trial in Duchenne muscular dystrophy shows vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug by Conklin, Laurie S., Damsker, Jesse M., Hoffman, Eric P., Jusko, William J., Mavroudis, Panteleimon D., Schwartz, Benjamin D., Mengle-Gaw, Laurel J., Smith, Edward C., Mah, Jean K., Guglieri, Michela, Nevo, Yoram, Kuntz, Nancy, McDonald, Craig M., Tulinius, Mar, Ryan, Monique M., Webster, Richard, Castro, Diana, Finkel, Richard S., Smith, Andrea L., Morgenroth, Lauren P., Arrieta, Adrienne, Shimony, Maya, Jaros, Mark, Shale, Phil, McCall, John M., Hathout, Yetrib, Nagaraju, Kanneboyina, van den Anker, John, Ward, Leanne M., Ahmet, Alexandra, Cornish, Michaelyn R., Clemens, Paula R.

“…[Display omitted] We report a first-in-patient study of vamorolone, a first-in-class dissociative steroidal anti-inflammatory drug, in Duchenne muscular…”
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Efficacy and Safety of Vamorolone Over 48 Weeks in Boys With Duchenne Muscular Dystrophy: A Randomized Controlled Trial by Dang, Utkarsh J, Damsker, Jesse M, Guglieri, Michela, Clemens, Paula R, Perlman, Seth J, Smith, Edward C, Horrocks, Iain, Finkel, Richard S, Mah, Jean K, Deconinck, Nicolas, Goemans, Nathalie M, Haberlová, Jana, Straub, Volker, Mengle-Gaw, Laurel, Schwartz, Benjamin D, Harper, Amy, Shieh, Perry B, De Waele, Liesbeth, Castro, Diana, Yang, Michele L, Ryan, Monique M, McDonald, Craig M, Tulinius, Mar, Webster, Richard I, Mcmillan, Hugh J, Kuntz, Nancy, Rao, Vamshi K, Baranello, Giovanni, Spinty, Stefan, Childs, Anne-Marie, Sbrocchi, Annie M, Selby, Kathryn A, Monduy, Migvis, Nevo, Yoram, Vilchez, Juan J, Nascimento-Osorio, Andres, Niks, Erik H, De Groot, Imelda J M, Katsalouli, Marina, Van Den Anker, John N, Ward, Leanne M, Leinonen, Mika, D'Alessandro, Andrea L, Hoffman, Eric P

“…Vamorolone is a dissociative agonist of the glucocorticoid receptor that has shown similar efficacy and reduced safety concerns in comparison with prednisone…”
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Cyclooxygenase-2 inhibitors: promise or peril? by Laurel J. Mengle-Gaw, Benjamin D. Schwartz

“…THE discovery of two isoforms of the cyclooxygenase enzyme, COX-1 and COX-2, and the development of COX-2-specific inhibitors as anti-inflammatories and…”
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Efficacy and Safety of Vamorolone in Duchenne Muscular Dystrophy: A 30-Month Nonrandomized Controlled Open-Label Extension Trial by Mah, Jean K, Clemens, Paula R, Guglieri, Michela, Smith, Edward C, Finkel, Richard S, Tulinius, Mar, Nevo, Yoram, Ryan, Monique M, Webster, Richard, Castro, Diana, Kuntz, Nancy L, McDonald, Craig M, Damsker, Jesse M, Schwartz, Benjamin D, Mengle-Gaw, Laurel J, Jackowski, Stefan, Stimpson, Georgia, Ridout, Deborah A, Ayyar-Gupta, Vandana, Baranello, Giovanni, Manzur, Adnan Y, Muntoni, Francesco, Gordish-Dressman, Heather, Leinonen, Mika, Ward, Leanne M, Hoffman, Eric P, Dang, Utkarsh J

“…Vamorolone is a synthetic steroidal drug with potent anti-inflammatory properties. Initial open-label, multiple ascending dose-finding studies of vamorolone…”
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Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects by Simon, L S, Lanza, F L, Lipsky, P E, Hubbard, R C, Talwalker, S, Schwartz, B D, Isakson, P C, Geis, G S

“…To investigate the efficacy and safety of SC-58635 (celecoxib), an antiinflammatory and analgesic agent that acts by selective cyclooxygenase 2 (COX-2)…”
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Clinical and histological assessment of collagen-induced arthritis progression in the diabetes-resistant BB/Wor rat by Knoerzer, D B, Donovan, M G, Schwartz, B D, Mengle-Gaw, L J

“…Collagen-induced arthritis in the diabetes-resistant BB (DR BB)/Wor rat is a severe, aggressive disease initiated by immunization with heterologous native Type…”
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A peptidomimetic that specifically inhibits human leukocyte antigen DRB10401-restricted T cell proliferation by Woulfe, S L, Bono, C P, Zacheis, M L, Welply, J K, Kirschmann, D A, Baudino, T A, Wang, Y, Stone, D A, Hanson, G J, Vuletich, J L, Bedell, L J, Schwartz, B D, Howard, S C

“…The ability of a peptidomimetic (SC-67655) to block the peptide binding site of the rheumatoid arthritis-linked human leukocyte antigen encoded by the…”
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An Improved Method for Isolation of H-2 and Ia Alloantigens with Immunoprecipitation Induced by Protein A-Bearing Staphylococci by Cullen, Susan E, Schwartz, Benjamin D

“…Mouse alloantigens, including the histocompatibility (H-2) and immune response linked (Ia) antigen molecules, can be readily isolated by a new precipitation…”
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Efficacy and safety of tacrolimus in patients with rheumatoid arthritis: A double‐blind trial by Yocum, David E., Furst, Daniel E., Kaine, Jeffrey L., Baldassare, Andrew R., Stevenson, Jon T., Borton, Mary Ann, Mengle‐Gaw, Laurel J., Schwartz, Benjamin D., Wisemandle, Wayne, Mekki, Qais A.

“…Objective To evaluate the efficacy and safety of tacrolimus as monotherapy in controlling the signs and symptoms of patients with rheumatoid arthritis (RA)…”
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Tacrolimus in rheumatoid arthritis patients receiving concomitant methotrexate: A six-month, open-label study by KREMER, Joel M, HABROS, Joseph S, KOLBA, Karen S, KAINE, Jeffrey L, BORTON, Mary Ann, MENGLE-GAW, Laurel J, SCHWARTZ, Benjamin D, WISEMANDLE, Wayne, MEKKI, Qais A

“…To assess the safety of tacrolimus used in combination with oral methotrexate (MTX) to control the signs and symptoms of rheumatoid arthritis (RA) in patients…”
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Isolation of H-2 Alloantigens Solubilized by the Detergent NP-40 by Schwartz, Benjamin D, Nathenson, Stanley G

“…Murine tumor cells of two different H-2 genotypes (H-2b and H-2d) were radiolabeled in suspension culture with 3H-fucose, and intact, labeled cells were…”
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Isoelectric Focusing of Guinea Pig Ia Antigens by Schwartz, Benjamin D, Gordon, Diane, Thomas, David W

“…To ascertain whether guinea pig Ia antigen-bearing molecules might act as receptors for exogenous antigens, Ia molecules from strain 2 and strain 13 guinea…”
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Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig by Knoerzer, D B, Karr, R W, Schwartz, B D, Mengle-Gaw, L J

“…Antigen-specific T cell activation requires two independent signalling events, one mediated through T cell receptor engagement by the antigen-presenting…”
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Macrophage Ia Antigens by Cowing, Carol, Schwartz, Benjamin D., Dickler, Howard B.

“…By indirect immunofluorescence and microcytotoxicity it was demonstrated that different populations of murine macrophages bear different amounts of Ia antigens…”
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Structural Differences Between the Ia Antigens Determined by the I-A and I-C Subregions by Cullen, Susan E, Littman, Dan R, Schwartz, Benjamin D

“…Ia antigens isolated from radiolabeled spleen cells by immune precipitation from detergent extracts using subregion specific anti-Ia sera showed superficial…”
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Labeling Characteristics and Separation of Ia Antigen Subunits by Schwartz, Benjamin D, Vitetta, Ellen S, Cullen, Susan E

“…Experiments with biosynthetic incorporation of 3H-amino acids into murine and guinea pig Ia antigens have indicated that these antigens consist of two…”
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Tacrolimus in rheumatoid arthritis patients receiving concomitant methotrexate by Kremer, Joel M., Habros, Joseph S., Kolba, Karen S., Kaine, Jeffrey L., Borton, Mary Ann, Mengle‐Gaw, Laurel J., Schwartz, Benjamin D., Wisemandle, Wayne, Mekki, for the Tacrolimus‐Methotrexate Rheumatoid Arthritis Study Group, Qais A.

“…Objective To assess the safety of tacrolimus used in combination with oral methotrexate (MTX) to control the signs and symptoms of rheumatoid arthritis (RA) in…”
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Guinea Pig Homologues of TL and QA-2 Antigens by Schwartz, Benjamin D, Cigen, Ragnhild, Berggard, Ingemar, Shevach, Ethan M

“…The H-2, thymus-leukemia (TL), and Qa-2 antigens of mice are encoded by closely linked genes on murine chromosome 17, and have structural similiarity in that…”
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