Search Results - "SCHWÄBLE, J"

Bis(1H-2-indolyl)-1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3 by TELLER, S, KRÄMER, D, SERVE, H, BÖHMER, F-D, BÖHMER, S-A, TSE, K. F, SMALL, D, MAHBOOBI, S, WALLRAPP, C, BECKERS, T, KRATZ-ALBERS, K, SCHWÄBLE, J

“…Aberrant expression and activating mutations of the class III receptor tyrosine kinase Flt3 (Flk-2, STK-1) have been linked to poor prognosis in acute myeloid…”
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Expression of the p14 tumor suppressor predicts survival in acute myeloid leukemia

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Oncogenic receptor tyrosine kinase in leukemia by Mizuki, M, Ueda, S, Matsumura, I, Ishiko, J, Schwäble, J, Serve, H, Kanakura, Y

“…Growth, survival and differentiation of hematopoietic cells are regulated by the interaction between hematopoietic growth factors and their receptors. While…”
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Detection of Rare Target Genes on Northern Blots with cDNA Probes Labeled by Reverse Transcriptase–Polymerase Chain Reaction with Simultaneous Digoxigenin Incorporation by Schwäble, J., Wittrock, J., Schweizer, P., Girgert, R.

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Expression of the p14ARF tumor suppressor predicts survival in acute myeloid leukemia by MÜLLER-TIDOW, C, METZELDER, S. K, LUDWIG, W-D, HEINECKE, A, BÜCHNER, T, BERDEL, W. E, SERVE, H, BUERGER, H, PACKEISEN, J, GANSER, A, HEIL, G, KÜGLER, K, ADIGÜZEL, G, SCHWÄBLE, J, STEFFEN, B

“…Cell cycle aberrations are associated with therapy outcome in many types of cancer. We analyzed mRNA expression levels of 18 cell cycle-related genes in bone…”
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Neuroblastoma: induction of differentiation (Part I). Basical science in pediatric surgery by Girgert, R, Schweizer, P, Schwäble, J

“…Neuroblastoma is the second-most common solid tumor in childhood. The majority of patients have a very poor outcome due to aggressive growth and metastatic…”
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Mutations of growth factor receptor Flt3 in acute myeloid leukemia: transformation of myeloid cells by Ras-dependent and Ras-independent mechanisms by Müller-Tidow, C, Steur, C, Mizuki, M, Schwäble, J, Brandts, C, Berdel, W E, Serve, H

“…The tyrosine kinase receptor Flt3 mediates important functions in early hematopoietic progenitors. Recently mutations of a growth factor receptor have been…”
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AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations by Choudhary, Chunaram, Schwäble, Joachim, Brandts, Christian, Tickenbrock, Lara, Sargin, Bülent, Kindler, Thomas, Fischer, Thomas, Berdel, Wolfgang E., Müller-Tidow, Carsten, Serve, Hubert

“…Activating mutations of Flt3 are found in approximately one third of patients with acute myeloid leukemia (AML) and are an attractive drug target. Two classes…”
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Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations by Mizuki, Masao, Schwäble, Joachim, Steur, Claudia, Choudhary, Chunaram, Agrawal, Shuchi, Sargin, Bülent, Steffen, Björn, Matsumura, Itaru, Kanakura, Yuzuru, Böhmer, Frank D., Müller-Tidow, Carsten, Berdel, Wolfgang E., Serve, Hubert

“…The receptor tyrosine kinase Flt3 is expressed and functionally important in early myeloid progenitor cells and in the majority of acute myeloid leukemia (AML)…”
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Flt3 tandem duplication mutations cooperate with Wnt signaling in leukemic signal transduction by Tickenbrock, Lara, Schwäble, Joachim, Wiedehage, Markus, Steffen, Björn, Sargin, Bülent, Choudhary, Chunaram, Brandts, Christian, Berdel, Wolfgang E., Müller-Tidow, Carsten, Serve, Hubert

“…Activating Flt3 mutations occur in about 30% of patients with acute myeloid leukemia (AML), often as in-frame internal tandem duplication (ITD) at the…”
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Identification of metastasis-associated receptor tyrosine kinases in non-small cell lung cancer by MÜLLER-TIDOW, Carsten, DIEDERICHS, Sven, BRANDTS, Christian H, BERDEL, Wolfgang E, SERVE, Hubert, BULK, Etmar, POHLE, Thorsten, STEFFEN, Björn, SCHWÄBLE, Joachim, PLEWKA, Sylvia, THOMAS, Michael, METZGER, Ralf, SCHNEIDER, Paul M

“…Development of distant metastasis after tumor resection is the leading cause of death in early-stage non-small cell lung cancer (NSCLC). Receptor tyrosine…”
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The molecular pathogenesis of acute myeloid leukemia by Steffen, Björn, Müller-Tidow, Carsten, Schwäble, Joachim, Berdel, Wolfgang E., Serve, Hubert

“…The description of the molecular pathogenesis of acute myeloid leukemias (AML) has seen dramatic progress over the last years. Two major types of genetic…”
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RGS2 is an important target gene of Flt3-ITD mutations in AML and functions in myeloid differentiation and leukemic transformation by Schwäble, Joachim, Choudhary, Chunaram, Thiede, Christian, Tickenbrock, Lara, Sargin, Bülent, Steur, Claudia, Rehage, Maike, Rudat, Annika, Brandts, Christian, Berdel, Wolfgang E., Müller-Tidow, Carsten, Serve, Hubert

“…Activating fetal liver tyrosine kinase 3 (Flt3) mutations represent the most common genetic aberrations in acute myeloid leukemia (AML). Most commonly, they…”
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High-Throughput Analysis of Genome-Wide Receptor Tyrosine Kinase Expression in Human Cancers Identifies Potential Novel Drug Targets by MÜLLER-TIDOW, Carsten, SCHWÄBLE, Joachim, SCHNEIDER, Paul M, BÜCHNER, Thomas, BRANDTS, Christian, BERDEL, Wolfgang E, SERVE, Hubert, STEFFEN, Björn, TIDOW, Nicola, BRANDT, Burkhardt, BECKER, Kerstin, SCHULZE-BAHR, Eric, HALFTER, Hartmut, VOGT, Ulf, METZGER, Ralf

“…Novel high-throughput analyses in molecular biology allow sensitive and rapid identification of disease-related genes and drug targets. We have used…”
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Flt3 receptor tyrosine kinase as a drug target in leukemia by Schmidt-Arras, Dirk, Schwäble, Joachim, Böhmer, Frank-D, Serve, Hubert

“…The hematopoietic class III receptor tyrosine kinase (RTK) Flt3 (Flk2, STK1) has recently received much attention as a potential drug target. Activation of…”
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The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARα and regulates differentiation of hematopoietic cells by WORCH, Jennifer, TICKENBROCK, Lara, MÜLLER-TIDOW, Carsten, SCHWÄBLE, Joachim, STEFFEN, Björn, CAUVET, Thomas, MLODY, Barbara, BUERGER, Horst, KOEFFLER, H. Phillip, BERDEL, Wolfgang E, SERVE, Hubert

“…Microarray analyses were performed to identify target genes that are shared by the acute myeloid leukemia (AML) translocation products PML-RARα, PLZF-RARα and…”
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