Search Results - "SCHUSTER, Victor L"

Inhibition of Prostaglandin Transporter (PGT) Promotes Perfusion and Vascularization and Accelerates Wound Healing in Non-Diabetic and Diabetic Rats by Liu, Zhongbo, Benard, Outhiriaradjou, Syeda, Mahrukh M, Schuster, Victor L, Chi, Yuling

“…Peripheral ischemia, resulting from diminished arterial flow and defective local vascularization, is one of the main causes of impaired wound healing in…”
Get full text

Failure of Postnatal Ductus Arteriosus Closure in Prostaglandin Transporter-Deficient Mice by CHANG, Hee-Yoon, LOCKER, Joseph, RUN LU, SCHUSTER, Victor L

“…Prostaglandin E(2) (PGE(2)) plays a major role both in maintaining patency of the fetal ductus arteriosus and in closure of the ductus arteriosus after birth…”
Get full text

Mangiferin Accelerates Glycolysis and Enhances Mitochondrial Bioenergetics by Liu, Zhongbo, Apontes, Pasha, Fomenko, Ekaterina V, Chi, Nan, Schuster, Victor L, Kurland, Irwin J, Pessin, Jeffrey E, Chi, Yuling

“…One of the main causes of hyperglycemia is inefficient or impaired glucose utilization by skeletal muscle, which can be exacerbated by chronic high caloric…”
Get full text

Inhibition of the Prostaglandin Transporter PGT Lowers Blood Pressure in Hypertensive Rats and Mice by Chi, Yuling, Jasmin, Jean-Francois, Seki, Yoshinori, Lisanti, Michael P, Charron, Maureen J, Lefer, David J, Schuster, Victor L

“…Inhibiting the synthesis of endogenous prostaglandins with nonsteroidal anti-inflammatory drugs exacerbates arterial hypertension. We hypothesized that the…”
Get full text

The two-step model of prostaglandin signal termination: in vitro reconstitution with the prostaglandin transporter and prostaglandin 15 dehydrogenase by Nomura, Teruhisa, Lu, Run, Pucci, Michael L, Schuster, Victor L

“…Termination of prostaglandin (PG) signaling has been proposed to involve carrier-mediated uptake across the plasma membrane followed by cytoplasmic oxidation…”
Get more information

Plasma 15-Hydroxyeicosatetraenoic Acid Predicts Treatment Outcomes in Aspirin-Exacerbated Respiratory Disease by Jerschow, Elina, MD, MSc, Edin, Matthew L., PhD, Pelletier, Teresa, BA, Abuzeid, Waleed M., MD, Akbar, Nadeem A., MD, Gibber, Marc, MD, Fried, Marvin, MD, Lih, Fred B., BA, Gruzdev, Artiom, PhD, Bradbury, J. Alyce, PhD, Han, Weiguo, PhD, Hudes, Golda, MD, PhD, Keskin, Taha, MD, Schuster, Victor L., MD, Spivack, Simon, MD, MPH, Zeldin, Darryl C., MD, Rosenstreich, David, MD

“…Background Aspirin desensitization followed by daily aspirin provides therapeutic benefits to patients with aspirin-exacerbated respiratory disease (AERD). It…”
Get full text

Development of a high-affinity inhibitor of the prostaglandin transporter by Chi, Yuling, Min, Jaeki, Jasmin, Jean-Francois, Lisanti, Michael P, Chang, Young-Tae, Schuster, Victor L

“…Prostaglandin E(2) (PGE(2)) triggers a vast array of biological signals and physiological events. The prostaglandin transporter (PGT) controls PGE(2) influx…”
Get more information

Molecular mechanisms of prostaglandin transport by Schuster, V L

“…Despite the fact that prostaglandins (PGs) have low intrinsic permeabilities across the plasma membrane, they must cross it twice: first upon release from the…”
Get full text

Dietary salt induces transcription of the prostaglandin transporter gene in renal collecting ducts by Chi, Yuling, Pucci, Michael L, Schuster, Victor L

“…Prostaglandin E(2) (PGE(2)) plays an important role in maintaining body fluid homeostasis by activating its receptors on the renal collecting duct (CD) to…”
Get more information

Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C by Lu, R, Chan, B S, Schuster, V L

“…Conserved from fish to mammals, renal proximal tubule organic anion secretion plays an important role in drug and xenobiotic elimination. Studies with the…”
Get full text

Identification of a new class of prostaglandin transporter inhibitors and characterization of their biological effects on prostaglandin E2 transport by Chi, Yuling, Khersonsky, Sonya M, Chang, Young-Tae, Schuster, Victor L

“…Prostaglandins (PGs) are involved in several major signaling pathways. Their effects are terminated when they are transported across cell membranes and…”
Get more information

Arteriovenous metabolomics in pigs reveals CFTR regulation of metabolism in multiple organs by Bae, Hosung, Kim, Bo Ram, Jung, Sunhee, Le, Johnny, van der Heide, Dana, Yu, Wenjie, Park, Sang Hee, Hilkin, Brieanna M., Gansemer, Nicholas D., Powers, Linda S., Kang, Taekyung, Meyerholz, David K., Schuster, Victor L., Jang, Cholsoon, Welsh, Michael J.

“…Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF), a multiorgan disease that is characterized by…”
Get full text

Identification of lactate as a driving force for prostanoid transport by prostaglandin transporter PGT by Chan, Brenda S, Endo, Shinichi, Kanai, Naoaki, Schuster, Victor L

“…We previously characterized the prostaglandin (PG) transporter PGT as an exchanger in which [(3)H]PGE(2) influx is coupled to the efflux of a countersubstrate…”
Get more information

Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia by Ware, James S, Wain, Louise V, Channavajjhala, Sarath K, Jackson, Victoria E, Edwards, Elizabeth, Lu, Run, Siew, Keith, Jia, Wenjing, Shrine, Nick, Kinnear, Sue, Jalland, Mahli, Henry, Amanda P, Clayton, Jenny, O'Shaughnessy, Kevin M, Tobin, Martin D, Schuster, Victor L, Cook, Stuart, Hall, Ian P, Glover, Mark

“…Thiazide diuretics are among the most widely used treatments for hypertension, but thiazide-induced hyponatremia (TIH), a clinically significant adverse…”
Get full text

Identification and Characterization of a Prostaglandin Transporter by Kanai, Naoaki, Lu, Run, Satriano, Joseph A., Bao, Yi, Wolkoff, Allan W., Schuster, Victor L.

“…Carrier-mediated prostaglandin transport has been postulated to occur in many tissues. On the basis of sequence homology, the protein of unknown function…”
Get full text

The Prostaglandin Transporter: Eicosanoid Reuptake, Control of Signaling, and Development of High-Affinity Inhibitors as Drug Candidates by Schuster, Victor L, Chi, Yuling, Lu, Run

“…We discovered the prostaglandin transporter (PGT) and cloned the human cDNA and gene. PGT transports extracellular prostaglandins (PGs) into the cytoplasm for…”
Get full text

Medical Student Experience and Outcomes, as Well as Preceptor Experience, with Rapid Conversion of a Preclinical Medical School Course to a Remote-Based Learning Format in the Setting of the COVID-19 Pandemic by Grand, David, Schuster, Victor L., Pullman, James M., Golestaneh, Ladan, Raff, Amanda C.

“…Objectives To assess student outcomes and experiences, as well as preceptor experiences, after emergently converting a preclinical medical school renal course…”
Get full text

Prostaglandin transport by Schuster, Victor L

“…Newly synthesized prostaglandins (PGs) efflux from cells by simple diffusion, driven by pH and the membrane potential. Metabolic clearance requires…”
Get full text

The prostaglandin transporter PGT transports PGH2 by Chi, Yuling, Schuster, Victor L.

“…Prostaglandin H 2 not only serves as the common precursor of all other PGs, but also directly triggers signals (eg. platelet aggregation), depending on its…”
Get full text

The prostaglandin transporter PGT transports PGH(2) by Chi, Yuling, Schuster, Victor L

“…Prostaglandin H(2) not only serves as the common precursor of all other PGs, but also directly triggers signals (e.g. platelet aggregation), depending on its…”
Get full text