Search Results - "SCHUR, M"

An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation by Schur, Florian K. M., Obr, Martin, Hagen, Wim J. H., Wan, William, Jakobi, Arjen J., Kirkpatrick, Joanna M., Sachse, Carsten, Kräusslich, Hans-Georg, Briggs, John A. G.

“…Immature HIV-1 assembles at and buds from the plasma membrane before proteolytic cleavage of the viral Gag polyprotein induces structural maturation…”
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Inositol phosphates are assembly co-factors for HIV-1 by Dick, Robert A., Zadrozny, Kaneil K., Xu, Chaoyi, Schur, Florian K. M., Lyddon, Terri D., Ricana, Clifton L., Wagner, Jonathan M., Perilla, Juan R., Ganser-Pornillos, Barbie K., Johnson, Marc C., Pornillos, Owen, Vogt, Volker M.

“…A short, 14-amino-acid segment called SP1, located in the Gag structural protein 1 , has a critical role during the formation of the HIV-1 virus particle…”
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Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction by Fäßler, Florian, Dimchev, Georgi, Hodirnau, Victor-Valentin, Wan, William, Schur, Florian K. M.

“…The actin-related protein (Arp)2/3 complex nucleates branched actin filament networks pivotal for cell migration, endocytosis and pathogen infection. Its…”
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Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolution by Schur, Florian K. M., Hagen, Wim J. H., Rumlová, Michaela, Ruml, Tomáš, Müller, Barbara, Kräusslich, Hans-Georg, Briggs, John A. G.

“…Cryo-electron tomography and subtomogram averaging methods reveal the structure of the capsid lattice within intact heterogeneous immature HIV-1 particles…”
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Structure and architecture of immature and mature murine leukemia virus capsids by Qu, Kun, Glass, Bärbel, Doležal, Michal, Schur, Florian K. M., Murciano, Brice, Rein, Alan, Rumlová, Michaela, Ruml, Tomáš, Kräusslich, Hans-Georg, Briggs, John A. G.

“…Retroviruses assemble and bud from infected cells in an immature form and require proteolytic maturation for infectivity. The CA (capsid) domains of the Gag…”
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Structures of immature EIAV Gag lattices reveal a conserved role for IP6 in lentivirus assembly by Dick, Robert A, Xu, Chaoyi, Morado, Dustin R, Kravchuk, Vladyslav, Ricana, Clifton L, Lyddon, Terri D, Broad, Arianna M, Feathers, J Ryan, Johnson, Marc C, Vogt, Volker M, Perilla, Juan R, Briggs, John A G, Schur, Florian K M

“…Retrovirus assembly is driven by the multidomain structural protein Gag. Interactions between the capsid domains (CA) of Gag result in Gag multimerization,…”
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Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development by Morandell, Jasmin, Schwarz, Lena A., Basilico, Bernadette, Tasciyan, Saren, Dimchev, Georgi, Nicolas, Armel, Sommer, Christoph, Kreuzinger, Caroline, Dotter, Christoph P., Knaus, Lisa S., Dobler, Zoe, Cacci, Emanuele, Schur, Florian K. M., Danzl, Johann G., Novarino, Gaia

“…De novo loss of function mutations in the ubiquitin ligase-encoding gene Cullin3 ( CUL3) lead to autism spectrum disorder (ASD). In mouse, constitutive Cul3…”
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Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer by Obr, Martin, Ricana, Clifton L., Nikulin, Nadia, Feathers, Jon-Philip R., Klanschnig, Marco, Thader, Andreas, Johnson, Marc C., Vogt, Volker M., Schur, Florian K. M., Dick, Robert A.

“…Inositol hexakisphosphate (IP6) is an assembly cofactor for HIV-1. We report here that IP6 is also used for assembly of Rous sarcoma virus (RSV), a retrovirus…”
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A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly by Obr, Martin, Schur, Florian K M, Dick, Robert A

“…The small cellular molecule inositol hexakisphosphate (IP6) has been known for ~20 years to promote the in vitro assembly of HIV-1 into immature virus-like…”
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Cryo-electron microscopy of tubular arrays of HIV-1 Gag resolves structures essential for immature virus assembly by Bharat, Tanmay A. M., Menendez, Luis R. Castillo, Hagen, Wim J. H., Lux, Vanda, Igonet, Sebastien, Schorb, Martin, Schur, Florian K. M., Kräusslich, Hans-Georg, Briggs, John A. G.

“…The assembly of HIV-1 is mediated by oligomerization of the major structural polyprotein, Gag, into a hexameric protein lattice at the plasma membrane of the…”
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Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber’s Congenital Amaurosis by Sun, Da, Sahu, Bhubanananda, Gao, Songqi, Schur, Rebecca M., Vaidya, Amita M., Maeda, Akiko, Palczewski, Krzysztof, Lu, Zheng-Rong

“…Development of a gene delivery system with high efficiency and a good safety profile is essential for successful gene therapy. Here we developed a targeted…”
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Retrovirus maturation—an extraordinary structural transformation by Mattei, Simone, Schur, Florian KM, Briggs, John AG

“…[Display omitted] •Retroviruses mature via a major structural rearrangement.•Protein structure, interactions and virus architecture change.•Many aspects of the…”
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Synovial fluid cell counts and its role in the diagnosis of paediatric septic arthritis by Obana, K. K., Murgai, R. R., Schur, M., Broom, A. M., Hsu, A., Kay, R. M., Pace, J. L.

“…Abstract Purpose Clinical presentation of paediatric septic arthritis (SA) can be similar to other joint pathologies. Despite potential for infection in all…”
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MRI detection of breast cancer micrometastases with a fibronectin-targeting contrast agent by Zhou, Zhuxian, Qutaish, Mohammed, Han, Zheng, Schur, Rebecca M., Liu, Yiqiao, Wilson, David L., Lu, Zheng-Rong

“…Metastasis is the primary cause of death in breast cancer patients. Early detection of high-risk breast cancer, including micrometastasis, is critical in…”
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Multi-modal cryo-EM reveals trimers of protein A10 to form the palisade layer in poxvirus cores by Datler, Julia, Hansen, Jesse M., Thader, Andreas, Schlögl, Alois, Bauer, Lukas W., Hodirnau, Victor-Valentin, Schur, Florian K. M.

“…Poxviruses are among the largest double-stranded DNA viruses, with members such as variola virus, monkeypox virus and the vaccination strain vaccinia virus…”
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In Situ X-ray Diffraction Studies of the Crystallization of Layered Manganese Thioantimonates(III) under Hydrothermal Conditions by Engelke, L, Schaefer, M, Schur, M, Bensch, W

“…The solvothermal synthesis of the layered compound Mn2Sb2S5·DAP (DAP = 1,3-diaminopropane) has been studied using in situ energy-dispersive X-ray diffraction…”
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The Orthobunyavirus Germiston Enters Host Cells from Late Endosomes by Windhaber, Stefan, Xin, Qilin, Uckeley, Zina M, Koch, Jana, Obr, Martin, Garnier, Céline, Luengo-Guyonnot, Catherine, Duboeuf, Maëva, Schur, Florian K M, Lozach, Pierre-Yves

“…With more than 80 members worldwide, the genus in the family is a large genus of enveloped RNA viruses, many of which are emerging pathogens in humans and…”
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Lift-out cryo-FIBSEM and cryo-ET reveal the ultrastructural landscape of extracellular matrix by Zens, Bettina, Fäßler, Florian, Hansen, Jesse M, Hauschild, Robert, Datler, Julia, Hodirnau, Victor-Valentin, Zheden, Vanessa, Alanko, Jonna, Sixt, Michael, Schur, Florian K M

“…The extracellular matrix (ECM) serves as a scaffold for cells and plays an essential role in regulating numerous cellular processes, including cell migration…”
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Suppression of electromagnetic interference in electroretinography from a patient with an implanted left ventricular assist device (LVAD) by Schur, Rebecca M., Eck, Brendan L., Yuan, Alex

“…Purpose A left ventricular assist device (LVAD) is an implantable cardiac pump that uses a magnetically-levitating rotor to pump blood into circulation for…”
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Non-viral Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles by Sun, Da, Schur, Rebecca M., Sears, Avery E., Gao, Song-Qi, Vaidya, Amita, Sun, Wenyu, Maeda, Akiko, Kern, Timothy, Palczewski, Krzysztof, Lu, Zheng-Rong

“…Stargardt disease (STGD) is an autosomal recessive retinal disorder caused by a monogenic ABCA4 mutation. Currently, there is no effective therapy to cure…”
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