Search Results - "SCHUR, ELLEN"

Insulin Action to Inhibit Food Intake: Is It All in Your Head? by Schur, Ellen A, Tong, Jenny

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The Significance of Hypothalamic Inflammation and Gliosis for the Pathogenesis of Obesity in Humans by Sewaybricker, Leticia E, Huang, Alyssa, Chandrasekaran, Suchitra, Melhorn, Susan J, Schur, Ellen A

“…Abstract Accumulated preclinical literature demonstrates that hypothalamic inflammation and gliosis are underlying causal components of diet-induced obesity in…”
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Greater radiologic evidence of hypothalamic gliosis predicts adiposity gain in children at risk for obesity by Sewaybricker, Leticia E., Kee, Sarah, Melhorn, Susan J., Schur, Ellen A.

“…Objective This study investigated, in a large pediatric population, whether magnetic resonance imaging (MRI) evidence of mediobasal hypothalamic (MBH) gliosis…”
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Is Bariatric Surgery Brain Surgery? by Sewaybricker, Leticia E, Schur, Ellen A

“…Roux-en-Y gastric bypass (RYGB) reliably produces sustained weight losses, reduces circulating blood glucose, and lowers risk of type 2 diabetes (1)…”
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Obesity is associated with hypothalamic injury in rodents and humans by Thaler, Joshua P, Yi, Chun-Xia, Schur, Ellen A, Guyenet, Stephan J, Hwang, Bang H, Dietrich, Marcelo O, Zhao, Xiaolin, Sarruf, David A, Izgur, Vitaly, Maravilla, Kenneth R, Nguyen, Hong T, Fischer, Jonathan D, Matsen, Miles E, Wisse, Brent E, Morton, Gregory J, Horvath, Tamas L, Baskin, Denis G, Tschöp, Matthias H, Schwartz, Michael W

“…Rodent models of obesity induced by consuming high-fat diet (HFD) are characterized by inflammation both in peripheral tissues and in hypothalamic areas…”
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Regional brain response to visual food cues is a marker of satiety that predicts food choice by Mehta, Sonya, Melhorn, Susan J, Smeraglio, Anne, Tyagi, Vidhi, Grabowski, Thomas, Schwartz, Michael W, Schur, Ellen A

“…Background: Neuronal processes that underlie the subjective experience of satiety after a meal are not well defined.Objective: We investigated how satiety…”
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Strategies to Understand the Weight‐Reduced State: Genetics and Brain Imaging by Loos, Ruth J. F., Burant, Charles, Schur, Ellen A.

“…Most individuals with obesity or overweight have difficulty maintaining weight loss. The weight‐reduced state induces changes in many physiological processes…”
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Exposure to Gestational Diabetes Mellitus Prior to 26 Weeks Is Related to the Presence of Mediobasal Hypothalamic Gliosis in Children by Chandrasekaran, Suchitra, Melhorn, Susan, Olerich, Kelsey L W, Angelo, Brendan, Chow, Ting, Xiang, Anny, Schur, Ellen A, Page, Kathleen A

“…Intrauterine exposure to metabolic dysfunction leads to offspring metabolic dysfunction in human and rodent models, but underlying mechanisms are unclear. The…”
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In utero exposure to maternal diabetes or hypertension and childhood hypothalamic gliosis by Olerich, Kelsey L. W., Sewaybricker, Leticia E., Kee, Sarah, Melhorn, Susan J., Chandrasekaran, Suchitra, Schur, Ellen A.

“…Exposure to maternal diabetes (DM) or hypertension (HTN) during pregnancy impacts offspring metabolic health in childhood and beyond. Animal models suggest…”
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Adipokine profiles in preeclampsia by Chandrasekaran, Suchitra, Hunt, Hayley, Melhorn, Susan, Gammill, Hilary S., Schur, Ellen A.

“…Objectives: Hypertensive disorders of pregnancy (HDP), including preeclampsia (PE), are associated with short- and long-term maternal health complications, and…”
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FTO genotype impacts food intake and corticolimbic activation by Melhorn, Susan J, Askren, Mary K, Chung, Wendy K, Kratz, Mario, Bosch, Tyler A, Tyagi, Vidhi, Webb, Mary F, De Leon, Mary Rosalynn B, Grabowski, Thomas J, Leibel, Rudolph L, Schur, Ellen A

“…Variants in the first intron of the fat mass and obesity-associated (FTO) gene increase obesity risk. People with “high-risk” FTO genotypes exhibit preference…”
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Hypothalamic Gliosis Associated With High-Fat Diet Feeding Is Reversible in Mice: A Combined Immunohistochemical and Magnetic Resonance Imaging Study by Berkseth, Kathryn E, Guyenet, Stephan J, Melhorn, Susan J, Lee, Donghoon, Thaler, Joshua P, Schur, Ellen A, Schwartz, Michael W

“…Gliosis, the activation of astrocyte and microglial cell populations, is a hallmark of central nervous system injury and is detectable using either…”
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Pilot clinical trial of macimorelin to assess safety and efficacy in patients with cancer cachexia by Herodes, Megan, Anderson, Lindsey J., Shober, Samuel, Schur, Ellen A., Graf, Solomon A., Ammer, Nicola, Salas, Ramiro, Marcelli, Marco, Garcia, Jose M.

“…Background Cancer cachexia is associated with reduced body weight, appetite and quality of life (QOL) with no approved treatments. Growth hormone secretagogues…”
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Evidence That Hypothalamic Gliosis Is Related to Impaired Glucose Homeostasis in Adults With Obesity by Rosenbaum, Jennifer L, Melhorn, Susan J, Schoen, Stefan, Webb, Mary F, De Leon, Mary Rosalynn B, Humphreys, Madelaine, Utzschneider, Kristina M, Schur, Ellen A

“…Preclinical research implicates hypothalamic glial cell responses in the pathogenesis of obesity and type 2 diabetes (T2D). In the current study we sought to…”
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Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance in humans by Schur, Ellen A., Melhorn, Susan J., Oh, Seok‐Kyun, Lacy, J. Matthew, Berkseth, Kathryn E., Guyenet, Stephan J., Sonnen, Joshua A., Tyagi, Vidhi, Rosalynn, Mary, De Leon, B., Webb, Mary F., Gonsalves, Zenobia T., Fligner, Corinne L., Schwartz, Michael W., Maravilla, Kenneth R.

“…Objective To use quantitative magnetic resonance imaging (MRI) to test whether mediobasal hypothalamic (MBH) gliosis is associated with obesity and insulin…”
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Impaired Brain Satiety Responses After Weight Loss in Children With Obesity by Roth, Christian L, Melhorn, Susan J, De Leon, Mary Rosalynn B, Rowland, Maya G, Elfers, Clinton T, Huang, Alyssa, Saelens, Brian E, Schur, Ellen A

“…Obesity interventions often result in increased motivation to eat. We investigated relationships between obesity outcomes and changes in brain activation by…”
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Genetic and environmental influences on posttraumatic stress disorder symptoms and disinhibited eating behaviors by Afari, Niloofar, Gasperi, Marianna, Dochat, Cara, Wooldridge, Jennalee S., Herbert, Matthew S., Schur, Ellen A., Buchwald, Dedra S.

“…Posttraumatic stress disorder (PTSD) and eating disorders (ED) frequently co-occur, but the mechanisms underlying this association remain unclear. EDs are…”
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Associations of radiologic characteristics of the neonatal hypothalamus with early life adiposity gain by Sewaybricker, Leticia E., Melhorn, Susan J., Entringer, Sonja, Buss, Claudia, Wadhwa, Pathik D., Schur, Ellen A., Rasmussen, Jerod M.

“…Summary Background The mediobasal hypothalamus (MBH) is a key brain area for regulation of energy balance. Previous neuroimaging studies suggest that T2‐based…”
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Radiologic evidence that hypothalamic gliosis is improved after bariatric surgery in obese women with type 2 diabetes by van de Sande-Lee, Simone, Melhorn, Susan J., Rachid, Briana, Rodovalho, Sylka, De-Lima-Junior, José C., Campos, Brunno M., Pedro, Tatiane, Beltramini, Guilherme C., Chaim, Eliton A., Pareja, Jose C., Cendes, Fernando, Maravilla, Kenneth R., Schur, Ellen A., Velloso, Licio A.

“…Background/Objectives Hypothalamic neurons play a major role in the control of body mass. Obese subjects present radiologic signs of gliosis in the…”
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Effects of multiple cycles of weight loss and regain on the body weight regulatory system in rats by Rosenbaum, Jennifer L, Frayo, R Scott, Melhorn, Susan J, Cummings, David E, Schur, Ellen A

“…We studied the effects of multiple cycles of weight loss and regain on the defended body weight in rats. Thirty-six male Wistar rats were divided into three…”
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