Search Results - "SCHUMITZKY, Alan"

Prospective Trial on the Use of Trough Concentration versus Area under the Curve To Determine Therapeutic Vancomycin Dosing by Neely, Michael N, Kato, Lauren, Youn, Gilmer, Kraler, Lironn, Bayard, David, van Guilder, Michael, Schumitzky, Alan, Yamada, Walter, Jones, Brenda, Minejima, Emi

“…We hypothesized that dosing vancomycin to achieve trough concentrations of >15 mg/liter overdoses many adults compared to area under the concentration-time…”
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Analysis of combination drug therapy to develop regimens with shortened duration of treatment for tuberculosis by Drusano, George L, Neely, Michael, Van Guilder, Michael, Schumitzky, Alan, Brown, David, Fikes, Steven, Peloquin, Charles, Louie, Arnold

“…Tuberculosis remains a worldwide problem, particularly with the advent of multi-drug resistance. Shortening therapy duration for Mycobacterium tuberculosis is…”
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RPEM: Randomized Monte Carlo parametric expectation maximization algorithm by Chen, Rong, Schumitzky, Alan, Kryshchenko, Alona, Nieforth, Keith, Tomashevskiy, Michael, Hu, Shuhua, Garreau, Romain, Otalvaro, Julian, Yamada, Walter, Neely, Michael N.

“…Inspired from quantum Monte Carlo, by sampling discrete and continuous variables at the same time using the Metropolis–Hastings algorithm, we present a novel,…”
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An Algorithm for Nonparametric Estimation of a Multivariate Mixing Distribution with Applications to Population Pharmacokinetics by Yamada, Walter M, Neely, Michael N, Bartroff, Jay, Bayard, David S, Burke, James V, Guilder, Mike van, Jelliffe, Roger W, Kryshchenko, Alona, Leary, Robert, Tatarinova, Tatiana, Schumitzky, Alan

“…Population pharmacokinetic (PK) modeling has become a cornerstone of drug development and optimal patient dosing. This approach offers great benefits for…”
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Accurate Detection of Outliers and Subpopulations With Pmetrics, a Nonparametric and Parametric Pharmacometric Modeling and Simulation Package for R by NEELY, Michael N, VAN GUILDER, Michael G, YAMADA, Walter M, SCHUMITZKY, Alan, JELLIFFE, Roger W

“…Nonparametric population modeling algorithms have a theoretical superiority over parametric methods to detect pharmacokinetic and pharmacodynamic subgroups and…”
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Population pharmacokinetics/pharmacodynamics modeling: parametric and nonparametric methods by Jelliffe, R, Schumitzky, A, Van Guilder, M

“…As clinicians acquire experience with the clinical and pharmacokinetic behavior of a drug, it is usually optimal to record this experience in the form of a…”
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In Memoriam: Roger Jelliffe, MD, FCP, FAAPS by Neely, Michael, Bayard, David, van Guilder, Michael, Schumitzky, Alan

“…An obituary for Professor Roger Jelliffe who died on June 22. 2020. in Pasadena. CA. at the age of 91 is presented. Dr Jelliffe will forever be remembered as…”
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Achieving target voriconazole concentrations more accurately in children and adolescents by Neely, Michael, Margol, Ashley, Fu, Xiaowei, van Guilder, Michael, Bayard, David, Schumitzky, Alan, Orbach, Regina, Liu, Siyu, Louie, Stan, Hope, William

“…Despite the documented benefit of voriconazole therapeutic drug monitoring, nonlinear pharmacokinetics make the timing of steady-state trough sampling and…”
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Describing Assay Precision-Reciprocal of Variance Is Correct, Not CV Percent: Its Use Should Significantly Improve Laboratory Performance by Jelliffe, Roger W, Schumitzky, Alan, Bayard, David, Fu, Xiaowei, Neely, Michael

“…Describing assay error as percent coefficient of variation (CV%) fails as measurements approach zero. Results are censored if below some arbitrarily chosen…”
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Accurately Achieving Target Busulfan Exposure in Children and Adolescents With Very Limited Sampling and the BestDose Software by Neely, Michael, Philippe, Michael, Rushing, Teresa, Fu, Xiaowei, van Guilder, Michael, Bayard, David, Schumitzky, Alan, Bleyzac, Nathalie, Goutelle, Sylvain

“…Busulfan dose adjustment is routinely guided by plasma concentration monitoring using 4-9 blood samples per dose adjustment, but a pharmacometric Bayesian…”
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Two general methods for population pharmacokinetic modeling: non-parametric adaptive grid and non-parametric Bayesian by Tatarinova, Tatiana, Neely, Michael, Bartroff, Jay, van Guilder, Michael, Yamada, Walter, Bayard, David, Jelliffe, Roger, Leary, Robert, Chubatiuk, Alyona, Schumitzky, Alan

“…Population pharmacokinetic (PK) modeling methods can be statistically classified as either parametric or nonparametric (NP). Each classification can be divided…”
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Combination Treatment With Meropenem Plus Levofloxacin Is Synergistic Against Pseudomonas aeruginosa Infection in a Murine Model of Pneumonia by Louie, Arnold, Liu, Weiguo, VanGuilder, Michael, Neely, Michael N., Schumitzky, Alan, Jelliffe, Roger, Fikes, Steven, Kurhanewicz, Stephanie, Robbins, Nichole, Brown, David, Baluya, Dodge, Drusano, George L

“…Background. Meropenem plus levofloxacin treatment was shown to be a promising combination in our in vitro hollow fiber infection model. We strove to validate…”
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A two-compartment population pharmacokinetic-pharmacodynamic model of digoxin in adults, with implications for dosage by Jelliffe, Roger W, Milman, Mark, Schumitzky, Alan, Bayard, David, Van Guilder, Michael

“…A population pharmacokinetic/pharmacodynamic model of digoxin in adult subjects was originally developed by Reuning et al in 1973. They clearly described the…”
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Implicit dual control based on particle filtering and forward dynamic programming by Bayard, David S., Schumitzky, Alan

“…This paper develops a sampling‐based approach to implicit dual control. Implicit dual control methods synthesize stochastic control policies by systematically…”
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Parametric and nonparametric population methods : Their comparative performance in analysing a clinical dataset and two monte carlo simulation studies by BUSTAD, Aida, TERZIIVANOV, Dimiter, LEARY, Robert, PORT, Ruediger, SCHUMITZKY, Alan, JELLIFFE, Roger

“…This study examined parametric and nonparametric population modelling methods in three different analyses. The first analysis was of a real, although small,…”
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A Two-Compartment Population PharmacokineticPharmacodynamic Model of Digoxin in Adults, With Implications for Dosage by JELLIFFE, Roger W, MILMAN, Mark, SCHUMITZKY, Alan, BAYARD, David, VAN GUILDER, Michael

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Accurate detection of outliers and subpopulations with Pmetrics, a non-parametric and parametric pharmacometric modeling and simulation package for R by Neely, Michael, van Guilder, Michael, Yamada, Walter, Schumitzky, Alan, Jelliffe, Roger

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Nonparametric population modeling and Bayesian analysis by Jelliffe, Roger, Neely, Michael, Schumitzky, Alan, Bayard, David, Van Guilder, Michael, Botnen, Andreas, Bustad, Aida, Laing, Derek, Yamada, Walter, Bartroff, Jay, Tatarinova, Tatiana

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Population Pharmacokinetic/Pharmacodyanamic Mixture Models via Maximum a Posteriori Estimation by Wang, Xiaoning, Schumitzky, Alan, D'Argenio, David Z

“…Pharmacokinetic/pharmacodynamic phenotypes are identified using nonlinear random effects models with finite mixture structures. A maximum a posteriori…”
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Nonlinear random effects mixture models: Maximum likelihood estimation via the EM algorithm by Wang, Xiaoning, Schumitzky, Alan, D’Argenio, David Z.

“…Nonlinear random effects models with finite mixture structures are used to identify polymorphism in pharmacokinetic/pharmacodynamic (PK/PD) phenotypes. An EM…”
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