Search Results - "SCHULZKE, J. D."

Claudin‐2‐mediated cation and water transport share a common pore by Rosenthal, R., Günzel, D., Krug, S. M., Schulzke, J.‐D., Fromm, M., Yu, A. S. L.

“…Aim Claudin‐2 is a tight junction protein typically located in ‘leaky’ epithelia exhibiting large paracellular permeabilities like small intestine and proximal…”
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Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease by Zeissig, S, Bürgel, N, Günzel, D, Richter, J, Mankertz, J, Wahnschaffe, U, Kroesen, A J, Zeitz, M, Fromm, M, Schulzke, J-D

“…Background: Epithelial barrier function is impaired in Crohn’s disease. Aim: To define the underlying cellular mechanisms with special attention to tight…”
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Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation by Luettig, J, Rosenthal, R, Barmeyer, C, Schulzke, JD

“…The epithelial tight junction determines the paracellular water and ion movement in the intestine and also prevents uptake of larger molecules, including…”
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Structural and functional changes of the duodenum in human norovirus infection by Troeger, H, Loddenkemper, C, Schneider, T, Schreier, E, Epple, H-J, Zeitz, M, Fromm, M, Schulzke, J-D

“…Norovirus infection is the most frequent cause of infectious diarrhoea in the western world. This study aimed to characterise functionally and…”
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Tricellulin is regulated via interleukin-13-receptor α2, affects macromolecule uptake, and is decreased in ulcerative colitis by Krug, S M, Bojarski, C, Fromm, A, Lee, I M, Dames, P, Richter, J F, Turner, J R, Fromm, M, Schulzke, J-D

“…In the two inflammatory bowel diseases, ulcerative colitis (UC) and Crohn's disease (CD), altered expression of tight junction (TJ) proteins leads to an…”
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Downregulation of epithelial apoptosis and barrier repair in active Crohn’s disease by tumour necrosis factor α antibody treatment by Zeissig, S, Bojarski, C, Buergel, N, Mankertz, J, Zeitz, M, Fromm, M, Schulzke, J D

“…Background and aims: Barrier dysfunction is an important feature contributing to inflammation and diarrhoea in Crohn’s disease (CD). Recently, tumour necrosis…”
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Arcobacter butzleri isolates exhibit pathogenic potential in intestinal epithelial cell models by Karadas, G., Bücker, R., Sharbati, S., Schulzke, J.‐D., Alter, T., Gölz, G.

“…Aims The pathogenic potential of Arcobacter butzleri isolates on human (HT‐29/B6) and porcine epithelial (IPEC‐J2) cells was investigated by in vitro assays…”
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Increased intestinal permeability in malnourished patients with liver cirrhosis by Norman, K, Pirlich, M, Schulzke, J-D, Smoliner, C, Lochs, H, Valentini, L, Bühner, S

“…Background/objective: Malnutrition is a prominent feature in liver cirrhosis, with deleterious impact on clinical outcome. The objective of this study is to…”
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Resveratrol Prevents Campylobacter jejuni -Induced Leaky gut by Restoring Occludin and Claudin-5 in the Paracellular Leak Pathway by Lobo de Sá, F D, Heimesaat, M M, Bereswill, S, Nattramilarasu, P K, Schulzke, J D, Bücker, R

“…is a bacterial human pathogen causing gastroenteritis and sequelae like irritable bowel syndrome. Epidemiologists count the human campylobacteriosis by as the…”
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Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients by Epple, H-J, Schneider, T, Troeger, H, Kunkel, D, Allers, K, Moos, V, Amasheh, M, Loddenkemper, C, Fromm, M, Zeitz, M, Schulzke, J-D

“…Impairment of the gastrointestinal mucosal barrier contributes to progression of HIV infection. The purpose of this study was to investigate the effect of…”
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Celiac disease-like abnormalities in a subgroup of patients with irritable bowel syndrome by Wahnschaffe, Ulrich, Ullrich, R., Riecken, E.O., D. Schulzke, J.

“…Abdominal symptoms in the absence of mucosal abnormalities are features of both the irritable bowel syndrome (IBS) and latent/potential celiac disease (cd). To…”
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Cost-effectiveness of a 3-month intervention with oral nutritional supplements in disease-related malnutrition: a randomised controlled pilot study by Norman, K, Pirlich, M, Smoliner, C, Kilbert, A, Schulzke, J D, Ockenga, J, Lochs, H, Reinhold, T

“…Background/Objectives: Nutritional intervention with oral nutritional supplements (ONS) has been shown to increase quality of life in malnourished patients. We…”
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Epithelial apoptosis is a prominent feature of the epithelial barrier disturbance in intestinal inflammation: effect of pro-inflammatory interleukin-13 on epithelial cell function by Heller, F, Fromm, A, Gitter, A H, Mankertz, J, Schulzke, J-D

“…In ulcerative colitis, the T helper type 2 proinflammatory cytokine Interleukin-13 (IL-13) contributes as effector cytokine to the epithelial changes…”
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Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis by Schmitz, Heinz, Barmeyer, Christian, Fromm ‡, MichaeL, Runkel §, Norbert, Foss ∥, Hans-Dieter, Bentzel ¶, Carl J., Riecken, Ernst-Otto, Schulzke, Jörg-Dieter

“…Background & Aims: Mechanisms of diarrhea in ulcerative colitis (UC) are still unknown. Functional and structural characterization of epithelial barrier and…”
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Epithelial transport and barrier function in occludin-deficient mice by Schulzke, J.D., Gitter, A.H., Mankertz, J., Spiegel, S., Seidler, U., Amasheh, S., Saitou, M., Tsukita, S., Fromm, M.

“…This study aimed at functional characterization of the tight junction protein occludin using the occludin-deficient mouse model. Epithelial transport and…”
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Complex phenotype of mice lacking occludin, a component of tight junction strands by Saitou, M, Furuse, M, Sasaki, H, Schulzke, J D, Fromm, M, Takano, H, Noda, T, Tsukita, S

“…Occludin is an integral membrane protein with four transmembrane domains that is exclusively localized at tight junction (TJ) strands. Here, we describe the…”
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Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma by Mankertz, J, Tavalali, S, Schmitz, H, Mankertz, A, Riecken, E O, Fromm, M, Schulzke, J D

“…The 65 kDa protein occludin is a membrane-spanning part of the epithelial tight junction, which is the main barrier of the paracellular pathway. The function…”
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Leaks in the epithelial barrier caused by spontaneous and TNF‐α‐induced single‐cell apoptosis by Gitter, Alfred H., Bendfeldt, Kerstin, Schulzke, Jörg-Dieter, Fromm, Michael

“…Current opinion assumes epithelial integrity during spontaneous apoptotic cell death. We measured, for the first time, the local conductances associated with…”
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Mechanisms of diarrhea in the interleukin-2-deficient mouse model of colonic inflammation by Barmeyer, C, Harren, M, Schmitz, H, Heinzel-Pleines, U, Mankertz, J, Seidler, U, Horak, I, Wiedenmann, B, Fromm, M, Schulzke, J D

“…Colitis in interleukin-2-deficient (IL-2(-/-)) mice resembles ulcerative colitis in humans. We studied epithelial transport and barrier function in IL-2(-/-)…”
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Permeability of human HT-29/B6 colonic epithelium as a function of apoptosis by Bojarski, C., Gitter, A. H., Bendfeldt, K., Mankertz, J., Schmitz, H., Wagner, S., Fromm, M., Schulzke, J. D.

“…The barrier function of colonic epithelia is challenged by apoptotic loss of enterocytes. In monolayers of human colonic HT-29/B6 cells, apoptosis induced by…”
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