Search Results - "SCHULENBURG, HINRICH"

Antibiotic combination efficacy (ACE) networks for a Pseudomonas aeruginosa model by Barbosa, Camilo, Beardmore, Robert, Schulenburg, Hinrich, Jansen, Gunther

“…The spread of antibiotic resistance is always a consequence of evolutionary processes. The consideration of evolution is thus key to the development of…”
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Alternative Evolutionary Paths to Bacterial Antibiotic Resistance Cause Distinct Collateral Effects by Barbosa, Camilo, Trebosc, Vincent, Kemmer, Christian, Rosenstiel, Philip, Beardmore, Robert, Schulenburg, Hinrich, Jansen, Gunther

“…When bacteria evolve resistance against a particular antibiotic, they may simultaneously gain increased sensitivity against a second one. Such collateral…”
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Modeling host-associating microbes under selection by Bansept, Florence, Obeng, Nancy, Schulenburg, Hinrich, Traulsen, Arne

“…The concept of fitness is often reduced to a single component, such as the replication rate in a given habitat. For species with multi-step life cycles, this…”
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Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen Pseudomonas aeruginosa by Barbosa, Camilo, Römhild, Roderich, Rosenstiel, Philip, Schulenburg, Hinrich

“…Evolution is at the core of the impending antibiotic crisis. Sustainable therapy must thus account for the adaptive potential of pathogens. One option is to…”
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The native microbiome of the nematode Caenorhabditis elegans: gateway to a new host-microbiome model by Dirksen, Philipp, Marsh, Sarah Arnaud, Braker, Ines, Heitland, Nele, Wagner, Sophia, Nakad, Rania, Mader, Sebastian, Petersen, Carola, Kowallik, Vienna, Rosenstiel, Philip, Félix, Marie-Anne, Schulenburg, Hinrich

“…Host-microbe associations underlie many key processes of host development, immunity, and life history. Yet, none of the current research on the central model…”
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High potency of sequential therapy with only β-lactam antibiotics by Batra, Aditi, Roemhild, Roderich, Rousseau, Emilie, Franzenburg, Sören, Niemann, Stefan, Schulenburg, Hinrich

“…Evolutionary adaptation is a major source of antibiotic resistance in bacterial pathogens. Evolution-informed therapy aims to constrain resistance by…”
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How long do Red Queen dynamics survive under genetic drift? A comparative analysis of evolutionary and eco-evolutionary models by Schenk, Hanna, Schulenburg, Hinrich, Traulsen, Arne

“…Red Queen dynamics are defined as long term co-evolutionary dynamics, often with oscillations of genotype abundances driven by fluctuating selection in…”
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The genomic basis of Red Queen dynamics during rapid reciprocal host–pathogen coevolution by Papkou, Andrei, Guzella, Thiago, Yang, Wentao, Koepper, Svenja, Pees, Barbara, Schalkowski, Rebecca, Barg, Mike-Christoph, Rosenstiel, Philip C., Teotónio, Henrique, Schulenburg, Hinrich

“…Red Queen dynamics, involving coevolutionary interactions between species, are ubiquitous, shaping the evolution of diverse biological systems. To date,…”
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Bdellovibrio and Like Organisms Are Predictors of Microbiome Diversity in Distinct Host Groups by Johnke, Julia, Fraune, Sebastian, Bosch, Thomas C. G., Hentschel, Ute, Schulenburg, Hinrich

“…Biodiversity is generally believed to be a main determinant of ecosystem functioning. This principle also applies to the microbiome and could consequently…”
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When the most potent combination of antibiotics selects for the greatest bacterial load: the smile-frown transition by Pena-Miller, Rafael, Laehnemann, David, Jansen, Gunther, Fuentes-Hernandez, Ayari, Rosenstiel, Philip, Schulenburg, Hinrich, Beardmore, Robert

“…Conventional wisdom holds that the best way to treat infection with antibiotics is to 'hit early and hit hard'. A favoured strategy is to deploy two…”
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Use of Viscous medium to study anthelmintic drug action in Caenorhabditis elegans by Hellinga, Jacqueline R., Krücken, Jürgen, Schulenburg, Hinrich, von Samson-Himmelstjerna, Georg

“…Caenorhabditis elegans is an appealing tool for experimental evolution and for working with antiparasitic drugs, from understanding the molecular mechanisms of…”
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CeMbio - The Caenorhabditis elegans Microbiome Resource by Dirksen, Philipp, Assié, Adrien, Zimmermann, Johannes, Zhang, Fan, Tietje, Adina-Malin, Marsh, Sarah Arnaud, Félix, Marie-Anne, Shapira, Michael, Kaleta, Christoph, Schulenburg, Hinrich, Samuel, Buck S

“…The study of microbiomes by sequencing has revealed a plethora of correlations between microbial community composition and various life-history characteristics…”
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Introduction. Ecological immunology by Schulenburg, Hinrich, Kurtz, Joachim, Moret, Yannick, Siva-Jothy, Michael T

“…An organism's fitness is critically reliant on its immune system to provide protection against parasites and pathogens. The structure of even simple immune…”
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High Innate Immune Specificity through Diversified C-Type Lectin-Like Domain Proteins in Invertebrates by Pees, Barbara, Yang, Wentao, Zárate-Potes, Alejandra, Schulenburg, Hinrich, Dierking, Katja

“…A key question in current immunity research is how the innate immune system can generate high levels of specificity. Evidence is accumulating that…”
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aFold - using polynomial uncertainty modelling for differential gene expression estimation from RNA sequencing data by Yang, Wentao, Rosenstiel, Philip, Schulenburg, Hinrich

“…Data normalization and identification of significant differential expression represent crucial steps in RNA-Seq analysis. Many available tools rely on…”
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Neutrality in the Metaorganism by Sieber, Michael, Pita, Lucía, Weiland-Bräuer, Nancy, Dirksen, Philipp, Wang, Jun, Mortzfeld, Benedikt, Franzenburg, Sören, Schmitz, Ruth A, Baines, John F, Fraune, Sebastian, Hentschel, Ute, Schulenburg, Hinrich, Bosch, Thomas C G, Traulsen, Arne

“…Almost all animals and plants are inhabited by diverse communities of microorganisms, the microbiota, thereby forming an integrated entity, the metaorganism…”
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Using a sequential regimen to eliminate bacteria at sublethal antibiotic dosages by Fuentes-Hernandez, Ayari, Plucain, Jessica, Gori, Fabio, Pena-Miller, Rafael, Reding, Carlos, Jansen, Gunther, Schulenburg, Hinrich, Gudelj, Ivana, Beardmore, Robert

“…We need to find ways of enhancing the potency of existing antibiotics, and, with this in mind, we begin with an unusual question: how low can antibiotic…”
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Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms by Rausch, Philipp, Rühlemann, Malte, Hermes, Britt M, Doms, Shauni, Dagan, Tal, Dierking, Katja, Domin, Hanna, Fraune, Sebastian, von Frieling, Jakob, Hentschel, Ute, Heinsen, Femke-Anouska, Höppner, Marc, Jahn, Martin T, Jaspers, Cornelia, Kissoyan, Kohar Annie B, Langfeldt, Daniela, Rehman, Ateequr, Reusch, Thorsten B H, Roeder, Thomas, Schmitz, Ruth A, Schulenburg, Hinrich, Soluch, Ryszard, Sommer, Felix, Stukenbrock, Eva, Weiland-Bräuer, Nancy, Rosenstiel, Philip, Franke, Andre, Bosch, Thomas, Baines, John F

“…The interplay between hosts and their associated microbiome is now recognized as a fundamental basis of the ecology, evolution, and development of both…”
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Multiple reciprocal adaptations and rapid genetic change upon experimental coevolution of an animal host and its microbial parasite by Schulte, Rebecca D, Makus, Carsten, Hasert, Barbara, Michiels, Nico K, Schulenburg, Hinrich

“…The coevolution between hosts and parasites is predicted to have complex evolutionary consequences for both antagonists, often within short time periods. To…”
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Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae by Greenwood, Jenny M, Milutinović, Barbara, Peuß, Robert, Behrens, Sarah, Esser, Daniela, Rosenstiel, Philip, Schulenburg, Hinrich, Kurtz, Joachim

“…The phenomenon of immune priming, i.e. enhanced protection following a secondary exposure to a pathogen, has now been demonstrated in a wide range of…”
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