Search Results - "SCHUHMACHER, Jochen"

DOTA-PESIN, a DOTA-conjugated bombesin derivative designed for the imaging and targeted radionuclide treatment of bombesin receptor-positive tumours by Zhang, Hanwen, Schuhmacher, Jochen, Waser, Beatrice, Wild, Damian, Eisenhut, Michael, Reubi, Jean Claude, Maecke, Helmut R

“…We aimed at designing and developing a novel bombesin analogue, DOTA-PEG(4)-BN(7-14) (DOTA-PESIN), with the goal of labelling it with (67/68)Ga and (177)Lu for…”
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Conjugation of DOTA Using Isolated Phenolic Active Esters:  The Labeling and Biodistribution of Albumin as Blood Pool Marker by Mier, Walter, Hoffend, Johannes, Krämer, Susanne, Schuhmacher, Jochen, Hull, William E, Eisenhut, Michael, Haberkorn, Uwe

“…A convenient method for the functionalization of proteins with DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) has been developed. For this…”
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A gallium-labeled DOTA-alpha-melanocyte- stimulating hormone analog for PET imaging of melanoma metastases by Froidevaux, Sylvie, Calame-Christe, Martine, Schuhmacher, Jochen, Tanner, Heidi, Saffrich, Rainer, Henze, Markus, Eberle, Alex N

“…Although (18)F-FDG PET is widely used for metastatic melanoma diagnosis, it is less accurate than desirable, particularly for small foci. Since both melanotic…”
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PET imaging of somatostatin receptors using [(68)GA]DOTA-D-Phe(1)-Tyr(3)-octreotide: First results in patients with meningiomas by Henze, Marcus, Schuhmacher, Jochen, Hipp, Peter, Kowalski, Jorg

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Bispecific tandem diabody for tumor therapy with improved antigen binding and pharmacokinetics by Kipriyanov, Sergey M, Moldenhauer, Gerhard, Schuhmacher, Jochen, Cochlovius, Björn, Von der Lieth, Claus-Wilhelm, Matys, E.Ronald, Little, Melvyn

“…To increase the valency, stability and therapeutic potential of bispecific antibodies, we designed a novel recombinant molecule that is bispecific and…”
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Gallium-68-DOTA-albumin as a PET blood-pool marker: experimental evaluation in vivo by Hoffend, Johannes, Mier, Walter, Schuhmacher, Jochen, Schmidt, Kerstin, Dimitrakopoulou-Strauss, Antonia, Strauss, Ludwig G., Eisenhut, Michael, Kinscherf, Ralf, Haberkorn, Uwe

“…Investigations into tumor angiogenesis and antiangiogenic treatment have renewed interest in tumor perfusion. To image tumor blood-pool by PET, suitable…”
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Characterization of ^sup 68^Ga-DOTA-D-Phe^sup 1^-Tyr^sup 3^-Octreotide Kinetics in Patients with Meningiomas by Henze, Marcus, Dimitrakopoulou-Strauss, Antonia, Milker-Zabel, Stefanie, Schuhmacher, Jochen

“…Because biopsy has a high risk of hemorrhage and the findings of CT and MRI are often ambiguous, especially at the base of the skull, additional methods for…”
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GRP Receptor-Targeted PET of a Rat Pancreas Carcinoma Xenograft in Nude Mice with a ^sup 68^Ga-Labeled Bombesin(6-14) Analog by Schuhmacher, Jochen, Zhang, Hanwen, Doll, Josef, Mäcke, Helmut R

“…Bombesin (BN), a 14-amino-acid peptide, shows high affinity for the human gastrin-releasing peptide receptor (GRP-r), which is overexpressed on several types…”
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Conjugation of DOTA using isolated phenolic active esters: The labelingand biodistribution of albumin as blood pool marker by Mier, Walter, Hoffend, Johannes, Kramer, Susanne, Schuhmacher, Jochen

“…A convenient method for the functionalization of proteins with DOTA (1,4,7,10-tetraazacyclododecane1,4,7,10-tetraacetic acid) has been developed. For this…”
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Immunoscintigraphy with positron emission tomography : Gallium-68 chelate imaging of breast cancer pretargeted with bispecific anti-MUC1/anti-Ga chelate antibodies by SCHUHMACHER, Jochen, KAUL, Sepp, KLIVENYI, Gabor, JUNKERMANN, Hans, MAGENER, Achim, HENZE, Marcus, DOLL, Josef, HABERKORN, Uwe, AMELUNG, Folker, BASTERT, Gunther

“…Pretargeting techniques that are based on the sequential administrations of bispecific antitumor/antimetal chelate antibodies (BS-MAbs), a blocker to saturate…”
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Treatment of human B cell lymphoma xenografts with a CD3 x CD19 diabody and T cells by Cochlovius, B, Kipriyanov, S M, Stassar, M J, Christ, O, Schuhmacher, J, Strauss, G, Moldenhauer, G, Little, M

“…The use of anti-CD3 x antitumor bispecific Abs is an attractive and highly specific approach in cancer therapy. Recombinant Ab technology now provides powerful…”
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Contribution of paramagnetic trace elements to the spin-lattice relaxation time in the liver by Schuhmacher, J H, Matys, E R, Clorius, J H, Hauser, H, Wesch, H, Maier-Borst, W

“…The relaxation times of water protons in rat liver tissue were measured with a NMR spectrometer at 20 MHz. The paramagnetic trace elements Cu, Fe, and Mn were…”
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Exceptional increase in somatostatin receptor expression in pancreatic neuroendocrine tumour, visualised with (68)Ga-DOTATOC PET by Henze, Marcus, Schuhmacher, Jochen, Dimitrakopoulou-Strauss, Antonia, Strauss, Ludwig G, Mäcke, Helmut R, Eisenhut, Michael, Haberkorn, Uwe

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Stable Expression of Soluble Therapeutic Peptides in Eukaryotic Cells by Multimerisation: Application to the HIV-1 Fusion Inhibitory Peptide C46 by Dervillez, Xavier, Hüther, Alexandra, Schuhmacher, Jochen, Griesinger, Christian, Cohen, Jacques H., von Laer, Dorothee, Dietrich, Ursula

“…A major drawback of therapeutic peptides is their short half‐life, which results in the need for multiple applications and high synthesis costs. To overcome…”
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Evaluation of the pharmacokinetics of 68Ga-DOTATOC in patients with metastatic neuroendocrine tumours scheduled for 90Y-DOTATOC therapy by Koukouraki, Sophia, Strauss, Ludwig G, Georgoulias, Vassilios, Schuhmacher, Jochen, Haberkorn, Uwe, Karkavitsas, Nikolaos, Dimitrakopoulou-Strauss, Antonia

“…The purpose of the study was to evaluate the pharmacokinetics of (68)Ga-DOTATOC in order to ascertain which parameters have the greatest impact on the global…”
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A Gallium-Labeled DOTA-{alpha}-Melanocyte- Stimulating Hormone Analog for PET Imaging of Melanoma Metastases by Froidevaux, Sylvie, Calame-Christe, Martine, Schuhmacher, Jochen, Tanner, Heidi, Saffrich, Rainer, Henze, Markus, Eberle, Alex N

“…Although (18)F-FDG PET is widely used for metastatic melanoma diagnosis, it is less accurate than desirable, particularly for small foci. Since both melanotic…”
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GRP Receptor-Targeted PET of a Rat Pancreas Carcinoma Xenograft in Nude Mice with a 68Ga-Labeled Bombesin(6-14) Analog by Schuhmacher, Jochen, Zhang, Hanwen, Doll, Josef, Macke, Helmut R, Matys, Ronald, Hauser, Harald, Henze, Marcus, Haberkorn, Uwe, Eisenhut, Michael

“…Bombesin (BN), a 14-amino-acid peptide, shows high affinity for the human gastrin-releasing peptide receptor (GRP-r), which is overexpressed on several types…”
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Characterization of 68Ga-DOTA-D-Phe1-Tyr3-Octreotide Kinetics in Patients with Meningiomas by Henze, Marcus, Dimitrakopoulou-Strauss, Antonia, Milker-Zabel, Stefanie, Schuhmacher, Jochen, Strauss, Ludwig G, Doll, Josef, Macke, Helmut R, Eisenhut, Michael, Debus, Jurgen, Haberkorn, Uwe

“…Because biopsy has a high risk of hemorrhage and the findings of CT and MRI are often ambiguous, especially at the base of the skull, additional methods for…”
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Pretargeting of human mammary carcinoma xenografts with bispecific anti-MUC1/anti-Ga chelate antibodies and immunoscintigraphy with PET by SCHUHMACHER, Jochen, KLIVENYI, Gabor, KAUL, Sepp, HENZE, Marcus, MATYS, Ronald, HAUSER, Harald, CLORIUS, John

“…We recently demonstrated the feasibility of combining enhanced tumor-to-tissue contrast and PET imaging for immunoscintigraphic tumor localization in pancreas…”
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Exceptional increase in somatostatin receptor expression in pancreatic neuroendocrine tumour, visualised with 68 Ga-DOTATOC PET by Henze, Marcus, Schuhmacher, Jochen, Dimitrakopoulou-Strauss, Antonia, Strauss, Ludwig G., M cke, Helmut R., Eisenhut, Michael, Haberkorn, Uwe

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