Search Results - "SCHUÊTZ, G"

Conservation Status of North American Birds in the Face of Future Climate Change by Langham, Gary M, Schuetz, Justin G, Distler, Trisha, Soykan, Candan U, Wilsey, Chad

“…Human-induced climate change is increasingly recognized as a fundamental driver of biological processes and patterns. Historic climate change is known to have…”
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Interindividual Variability in Cytochrome P450-Mediated Drug Metabolism by Tracy, Timothy S, Chaudhry, Amarjit S, Prasad, Bhagwat, Thummel, Kenneth E, Schuetz, Erin G, Zhong, Xiao-Bo, Tien, Yun-Chen, Jeong, Hyunyoung, Pan, Xian, Shireman, Laura M, Tay-Sontheimer, Jessica, Lin, Yvonne S

“…The cytochrome P450 (P450) enzymes are the predominant enzyme system involved in human drug metabolism. Alterations in the expression and/or activity of these…”
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Beyond Competitive Inhibition: Regulation of ABC Transporters by Kinases and Protein-Protein Interactions as Potential Mechanisms of Drug-Drug Interactions by Crawford, Rebecca R, Potukuchi, Praveen K, Schuetz, Erin G, Schuetz, John D

“…ATP-binding cassette (ABC) transporters are transmembrane efflux transporters mediating the extrusion of an array of substrates ranging from amino acids and…”
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Pheophorbide A: Fluorescent Bcrp Substrate to Measure Oral Drug-Drug Interactions in Real-Time In Vivo by Yasuda, Kazuto, Ganguly, Samit, Schuetz, Erin G

“…We investigated whether pheophorbide A (PhA) could serve as a selective breast cancer resistance protein (BCRP) substrate (victim) to screen in vivo using…”
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Stacked species distribution models and macroecological models provide congruent projections of avian species richness under climate change by Distler, Trisha, Schuetz, Justin G., Velásquez-Tibatá, Jorge, Langham, Gary M.

“…Aim: Using survey data for North American birds, we assess how well historical patterns of species richness are explained by stacked species distribution…”
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Zebrafish abcb11b mutant reveals strategies to restore bile excretion impaired by bile salt export pump deficiency by Ellis, Jillian L., Bove, Kevin E., Schuetz, Erin G., Leino, Daniel, Valencia, C. Alexander, Schuetz, John D., Miethke, Alexander, Yin, Chunyue

“…Bile salt export pump (BSEP) adenosine triphosphate–binding cassette B11 (ABCB11) is a liver‐specific ABC transporter that mediates canalicular bile salt…”
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Genetic contribution to variable human CYP3A-mediated metabolism by Lamba, Jatinder K, Lin, Yvonne S, Schuetz, Erin G, Thummel, Kenneth E

“…The human CYP3A subfamily plays a dominant role in the metabolic elimination of more drugs than any other biotransformation enzyme. CYP3A enzyme is localized…”
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Human UGT1A4 and UGT1A3 Conjugate 25-Hydroxyvitamin D3: Metabolite Structure, Kinetics, Inducibility, and Interindividual Variability by Wang, Zhican, Wong, Timothy, Hashizume, Takanori, Dickmann, Leslie Z, Scian, Michele, Koszewski, Nicholas J, Goff, Jesse P, Horst, Ronald L, Chaudhry, Amarjit S, Schuetz, Erin G, Thummel, Kenneth E

“…25-Hydroxyvitamin D3 (25OHD3) is used as a clinical biomarker for assessment of vitamin D status. Blood levels of 25OHD3 represent a balance between its…”
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Genetic predictors of interindividual variability in hepatic CYP3A4 expression by Lamba, Vishal, Panetta, John C, Strom, Stephen, Schuetz, Erin G

“…Variability in hepatic CYP3A4 cannot be explained by common CYP3A4 coding variants. We previously identified polymorphisms in pregnane X receptor (PXR) and…”
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Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters by Ganguly, Samit, Finkelstein, David, Shaw, Timothy I, Michalek, Ryan D, Zorn, Kimberly M, Ekins, Sean, Yasuda, Kazuto, Fukuda, Yu, Schuetz, John D, Mukherjee, Kamalika, Schuetz, Erin G

“…Abcg2/Bcrp and Abcb1a/Pgp are xenobiotic efflux transporters limiting substrate permeability in the gastrointestinal system and brain, and increasing renal and…”
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Drug transporters on arachnoid barrier cells contribute to the blood-cerebrospinal fluid barrier by Yasuda, Kazuto, Cline, Cynthia, Vogel, Peter, Onciu, Mihaela, Fatima, Soghra, Sorrentino, Brian P, Thirumaran, Ranjit K, Ekins, Sean, Urade, Yoshihiro, Fujimori, Ko, Schuetz, Erin G

“…The subarachnoid space, where cerebrospinal fluid (CSF) flows over the brain and spinal cord, is lined on one side by arachnoid barrier (AB) cells that form…”
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Magnetic vortex core reversal by excitation with short bursts of an alternating field by Stoll, H, Van Waeyenberge, B, Puzic, A, Chou, K. W, Tyliszczak, T, Hertel, R, Fähnle, M, Brückl, H, Rott, K, Reiss, G, Neudecker, I, Weiss, D, Back, C. H, Schütz, G

“…The vortex state, characterized by a curling magnetization, is one of the equilibrium configurations of soft magnetic materials and occurs in thin…”
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Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in Humans by Wong, Timothy, Wang, Zhican, Chapron, Brian D, Suzuki, Mizuki, Claw, Katrina G, Gao, Chunying, Foti, Robert S, Prasad, Bhagwat, Chapron, Alenka, Calamia, Justina, Chaudhry, Amarjit, Schuetz, Erin G, Horst, Ronald L, Mao, Qingcheng, de Boer, Ian H, Thornton, Timothy A, Thummel, Kenneth E

“…Metabolism of 25-hydroxyvitamin D3 (25OHD3) plays a central role in regulating the biologic effects of vitamin D in the body. Although cytochrome…”
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Vitamin D levels do not cause vitamin-drug interactions with dexamethasone or dasatinib in mice by Annu, Kavya, Yasuda, Kazuto, Caufield, William V, Freeman, 3rd, Burgess B, Schuetz, Erin G

“…Vitamin D3 (VD3) induces intestinal CYP3A that metabolizes orally administered anti-leukemic chemotherapeutic substrates dexamethasone (DEX) and dasatinib…”
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Pharmacogenetic Pathway Analysis of Docetaxel Elimination by Baker, SD, Verweij, J, Cusatis, GA, Schaik, RH, Marsh, S, Orwick, SJ, Franke, RM, Hu, S, Schuetz, EG, Lamba, V, Messersmith, WA, Wolff, AC, Carducci, MA, Sparreboom, A

“…The purpose of this study was to evaluate the affinity of docetaxel for 14 transporter proteins and assess the functional significance of 17 variants in five…”
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Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors by Tanner, Julie-Anne, Prasad, Bhagwat, Claw, Katrina G, Stapleton, Patricia, Chaudhry, Amarjit, Schuetz, Erin G, Thummel, Kenneth E, Tyndale, Rachel F

“…Cytochrome P450 2A6 CYP2A6: metabolizes several clinically relevant substrates, including nicotine, the primary psychoactive component in cigarette smoke…”
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Tracking the cultural niches of North American birds through time by Schuetz, Justin G., Johnston, Alison, Mascarenhas, André

“…Conservation efforts are constrained by our poor grasp of changing relationships between humans and other species. We used internet query data describing…”
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Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1 by Wang, Yue-Ming, Lin, Wenwei, Chai, Sergio C., Wu, Jing, Ong, Su Sien, Schuetz, Erin G., Chen, Taosheng

“…Activation of the pregnane X receptor (PXR) and subsequently its target genes, including those encoding drug transporters and metabolizing enzymes, while…”
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Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content by Shirasaka, Y, Chaudhry, A S, McDonald, M, Prasad, B, Wong, T, Calamia, J C, Fohner, A, Thornton, T A, Isoherranen, N, Unadkat, J D, Rettie, A E, Schuetz, E G, Thummel, K E

“…Large interindividual variability has been observed in the metabolism of CYP2C19 substrates in vivo . The study aimed to evaluate sources of this variability…”
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A neuroprotective phase precedes striatal degeneration upon nucleolar stress by Kreiner, G, Bierhoff, H, Armentano, M, Rodriguez-Parkitna, J, Sowodniok, K, Naranjo, J R, Bonfanti, L, Liss, B, Schütz, G, Grummt, I, Parlato, R

“…The nucleolus is implicated in sensing and responding to cellular stress by stabilizing p53. The pro-apoptotic effect of p53 is associated with several…”
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