Search Results - "SCHROETER, Hagen"

The metabolome of [2-14C](−)-epicatechin in humans: implications for the assessment of efficacy, safety and mechanisms of action of polyphenolic bioactives by Ottaviani, Javier I., Borges, Gina, Momma, Tony Y., Spencer, Jeremy P. E., Keen, Carl L., Crozier, Alan, Schroeter, Hagen

“…Diet is a major life style factor affecting human health, thus emphasizing the need for evidence-based dietary guidelines for primary disease prevention. While…”
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Absorption, metabolism, distribution and excretion of (−)-epicatechin: A review of recent findings by Borges, Gina, Ottaviani, Javier I., van der Hooft, Justin J.J., Schroeter, Hagen, Crozier, Alan

“…This paper reviews pioneering human studies, their limitations and recent investigations on the absorption, metabolism, distribution and excretion (aka…”
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Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial by Sloan, Richard P., Wall, Melanie, Yeung, Lok-Kin, Feng, Tianshu, Feng, Xinyang, Provenzano, Frank, Schroeter, Hagen, Lauriola, Vincenzo, Brickman, Adam M., Small, Scott A.

“…With the world's population aging, age-related memory decline is an impending cognitive epidemic. Assessing the impact of diet on cognitive aging, we conducted…”
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Recommending flavanols and procyanidins for cardiovascular health: Revisited by Ottaviani, Javier I., Heiss, Christian, Spencer, Jeremy P.E., Kelm, Malte, Schroeter, Hagen

“…The last 8 years have seen significant developments in our understanding of dietary flavanols and procyanidins in the context of human health and nutrition…”
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Methylxanthines enhance the effects of cocoa flavanols on cardiovascular function: randomized, double-masked controlled studies by Sansone, Roberto, Ottaviani, Javier I, Rodriguez-Mateos, Ana, Heinen, Yvonne, Noske, Dorina, Spencer, Jeremy P, Crozier, Alan, Merx, Marc W, Kelm, Malte, Schroeter, Hagen, Heiss, Christian

“…Cocoa flavanol intake, especially that of (-)-epicatechin, has been linked to beneficial effects on human cardiovascular function. However, cocoa also contains…”
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Reliance on self-reports and estimated food composition data in nutrition research introduces significant bias that can only be addressed with biomarkers by Ottaviani, Javier I, Sagi-Kiss, Virag, Schroeter, Hagen, Kuhnle, Gunter G C

“…The chemical composition of foods is complex, variable, and dependent on many factors. This has a major impact on nutrition research as it foundationally…”
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Flavonoid intake in European adults (18 to 64 years) by Vogiatzoglou, Anna, Mulligan, Angela A, Lentjes, Marleen A H, Luben, Robert N, Spencer, Jeremy P E, Schroeter, Hagen, Khaw, Kay-Tee, Kuhnle, Gunter G C

“…Flavonoids are a group of phenolic secondary plant metabolites that are ubiquitous in plant-based diets. Data from anthropological, observational and…”
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Assessing the respective contributions of dietary flavanol monomers and procyanidins in mediating cardiovascular effects in humans: randomized, controlled, double-masked intervention trial by Rodriguez-Mateos, Ana, Weber, Timon, Skene, Simon S, Ottaviani, Javier I, Crozier, Alan, Kelm, Malte, Schroeter, Hagen, Heiss, Christian

“…Flavanols are an important class of food bioactives that can improve vascular function even in healthy subjects. Cocoa flavanols (CFs) are composed principally…”
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Integrated Multi-Omic Analyses of the Genomic Modifications by Gut Microbiome-Derived Metabolites of Epicatechin, 5-(4'-Hydroxyphenyl)-γ-Valerolactone, in TNFalpha-Stimulated Primary Human Brain Microvascular Endothelial Cells by Corral-Jara, Karla Fabiola, Nuthikattu, Saivageethi, Rutledge, John, Villablanca, Amparo, Morand, Christine, Schroeter, Hagen, Milenkovic, Dragan

“…Cerebral blood vessels are lined with endothelial cells and form the blood-brain barrier. Their dysfunction constitutes a crucial event in the physiopathology…”
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Cocoa Flavanol Supplementation and the Effect on Insulin Resistance in Females Who Are Overweight or Obese: A Randomized, Placebo-Controlled Trial by Simpson, Elizabeth J, Mendis, Buddhike, Dunlop, Mandy, Schroeter, Hagen, Kwik-Uribe, Catherine, Macdonald, Ian A

“…There is interest in the impact that dietary interventions can have on preventing the transition from insulin resistance to type 2 diabetes, including a…”
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(--)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans by Schroeter, H, Heiss, C, Balzer, J, Kleinbongard, P, Keen, C.L, Hollenberg, N.K, Sies, H, Kwik-Uribe, C, Schmitz, H.H, Kelm, M

“…Epidemiological and medical anthropological investigations suggest that flavanol-rich foods exert cardiovascular health benefits. Endothelial dysfunction, a…”
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Biomarker-estimated flavan-3-ol intake is associated with lower blood pressure in cross-sectional analysis in EPIC Norfolk by Ottaviani, Javier I., Britten, Abigail, Lucarelli, Debora, Luben, Robert, Mulligan, Angela A., Lentjes, Marleen A., Fong, Reedmond, Gray, Nicola, Grace, Philip B., Mawson, Deborah H., Tym, Amy, Wierzbicki, Antonia, Forouhi, Nita G., Khaw, Kay-Tee, Schroeter, Hagen, Kuhnle, Gunter G. C.

“…Flavan-3-ols are a group of bioactive compounds that have been shown to improve vascular function in intervention studies. They are therefore of great interest…”
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Assessment of the dietary intake of total flavan-3-ols, monomeric flavan-3-ols, proanthocyanidins and theaflavins in the European Union by Vogiatzoglou, Anna, Mulligan, Angela A., Luben, Robert N., Lentjes, Marleen A. H., Heiss, Christian, Kelm, Malte, Merx, Marc W., Spencer, Jeremy P. E., Schroeter, Hagen, Kuhnle, Gunter G. C.

“…Dietary interventions with flavan-3-ols have shown beneficial effects on vascular function. The translation of these findings into the context of the health of…”
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Plant-Derived Flavanol (-)Epicatechin Enhances Angiogenesis and Retention of Spatial Memory in Mice by van Praag, Henriette, Lucero, Melanie J, Yeo, Gene W, Stecker, Kimberly, Heivand, Neema, Zhao, Chunmei, Yip, Ed, Afanador, Mia, Schroeter, Hagen, Hammerstone, John, Gage, Fred H

“…Diet and exercise have a profound impact on brain function. In particular, natural nutrients found in plants may influence neuronal survival and plasticity…”
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Acute Consumption of Flavanol-Rich Cocoa and the Reversal of Endothelial Dysfunction in Smokers by Heiss, Christian, Kleinbongard, Petra, Dejam, Andrè, Perré, Sandra, Schroeter, Hagen, Sies, Helmut, Kelm, Malte

“…This study was designed to assess the effect of flavanol-rich food on the circulating pool of bioactive nitric oxide (NO) and endothelial dysfunction in…”
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Improvement of Endothelial Function With Dietary Flavanols Is Associated With Mobilization of Circulating Angiogenic Cells in Patients With Coronary Artery Disease by Heiss, Christian, MD, DrMed, Jahn, Sarah, MB, Taylor, Melanie, BS, Real, Wendy May, BS, Angeli, Franca S., MD, Wong, Maelene L., BS, Amabile, Nicolas, MD, Prasad, Megha, BA, Rassaf, Tienush, MD, DrMed, Ottaviani, Javier I., PhD, Mihardja, Shirley, PhD, Keen, Carl L., PhD, Springer, Matthew L., PhD, Boyle, Andrew, MBBS, PhD, Grossman, William, MD, Glantz, Stanton A., PhD, Schroeter, Hagen, PhD, Yeghiazarians, Yerem, MD

“…Objectives In patients with coronary artery disease (CAD) medically managed according to currently accepted guidelines, we tested whether a 1-month dietary…”
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Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial by Heiss, Christian, Sansone, Roberto, Karimi, Hakima, Krabbe, Moritz, Schuler, Dominik, Rodriguez-Mateos, Ana, Kraemer, Thomas, Cortese-Krott, Miriam Margherita, Kuhnle, Gunter G. C., Spencer, Jeremy P. E., Schroeter, Hagen, Merx, Marc W., Kelm, Malte

“…Increased vascular stiffness, endothelial dysfunction, and isolated systolic hypertension are hallmarks of vascular aging. Regular cocoa flavanol (CF) intake…”
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Evaluation of (−)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake by Ottaviani, Javier I., Fong, Reedmond, Kimball, Jennifer, Ensunsa, Jodi L., Gray, Nicola, Vogiatzoglou, Anna, Britten, Abigail, Lucarelli, Debora, Luben, Robert, Grace, Philip B., Mawson, Deborah H., Tym, Amy, Wierzbicki, Antonia, Smith, A. David, Wareham, Nicholas J., Forouhi, Nita G., Khaw, Kay-Tee, Schroeter, Hagen, Kuhnle, Gunter G. C.

“…Data from dietary intervention studies suggest that intake of (−)-epicatechin mediates beneficial vascular effects in humans. However, population-based…”
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(‐)Epicatechin stimulates ERK‐dependent cyclic AMP response element activity and up‐regulates GluR2 in cortical neurons by Schroeter, Hagen, Bahia, Parmvir, Spencer, Jeremy P. E., Sheppard, Olivia, Rattray, Marcus, Cadenas, Enrique, Rice‐Evans, Catherine, Williams, Robert J.

“…Emerging evidence suggests that the cellular actions of flavonoids relate not simply to their antioxidant potential but also to the modulation of protein…”
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Cocoa flavanols lower vascular arginase activity in human endothelial cells in vitro and in erythrocytes in vivo by Schnorr, Oliver, Brossette, Tatjana, Momma, Tony Y., Kleinbongard, Petra, Keen, Carl L., Schroeter, Hagen, Sies, Helmut

“…The availability of l-arginine can be a rate-limiting factor for cellular NO production by nitric oxide synthases (NOS). Arginase competes with NOS for…”
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