Search Results - "SCHROEDER, Patricia E"

Evaluation of the use of static and dynamic models to predict drug-drug interaction and its associated variability: impact on drug discovery and early development by Peters, Sheila Annie, Schroeder, Patricia E, Giri, Nagdeep, Dolgos, Hugues

“…Simcyp, a population-based simulator, is widely used for evaluating drug-drug interaction (DDI) risks in healthy and disease populations. We compare the…”
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The Dihydroorotase Inhibitor 5-Aminoorotic Acid Inhibits the Metabolism in the Rat of the Cardioprotective Drug Dexrazoxane and Its One-Ring Open Metabolites by SCHROEDER, Patricia E, PATEL, Daywin, HASINOFF, Brian B

“…Dexrazoxane (ICRF-187) is clinically used as a doxorubicin cardioprotective agent and to prevent anthracycline extravasation injury. It may act by preventing…”
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METABOLISM OF THE ONE-RING OPEN METABOLITES OF THE CARDIOPROTECTIVE DRUG DEXRAZOXANE TO ITS ACTIVE METAL-CHELATING FORM IN THE RAT by SCHROEDER, Patricia E, HASINOFF, Brian B

“…Dexrazoxane (ICRF-187) is clinically used as a doxorubicin cardioprotective agent and may act by preventing iron-based oxygen free radical damage through the…”
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The metabolites of the cardioprotective drug dexrazoxane do not protect myocytes from doxorubicin-induced cytotoxicity by Hasinoff, Brian B, Schroeder, Patricia E, Patel, Daywin

“…The clinically approved cardioprotective agent dexrazoxane (ICRF-187) and two of its hydrolyzed metabolites (a one-ring open form of dexrazoxane and ADR-925)…”
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METABOLISM OF THE CARDIOPROTECTIVE DRUG DEXRAZOXANE AND ONE OF ITS METABOLITES BY ISOLATED RAT MYOCYTES, HEPATOCYTES, AND BLOOD by SCHROEDER, Patricia E, WANG, Gu-Qi, BURCZYNSKI, Frank J, HASINOFF, Brian B

“…The metabolism of the antioxidant cardioprotective agent dexrazoxane (ICRF-187) and one of its one-ring open metabolites to its active metal ion binding form N…”
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Dihydroorotase Catalyzes the Ring Opening of the Hydrolysis Intermediates of the Cardioprotective Drug Dexrazoxane (ICRF-187) by SCHROEDER, Patricia E, DAVIDSON, Jeffrey N, HASINOFF, Brian B

“…The enzyme kinetics of the hydrolysis of the one-ring open metabolites of the antioxidant cardioprotective agent dexrazoxane [ICRF-187;…”
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The doxorubicin-cardioprotective drug dexrazoxane undergoes metabolism in the rat to its metal ion-chelating form ADR-925 by SCHROEDER, Patricia E, HASINOFF, Brian B

“…Dexrazoxane is clinically used as a doxorubicin-cardioprotective agent and may act by preventing iron-based oxygen free-radical damage through the…”
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Metabolism of dexrazoxane (ICRF-187) used as a rescue agent in cancer patients treated with high-dose etoposide by SCHROEDER, Patricia E, JENSEN, Peter Buhl, SEHESTED, Maxwell, HOFLAND, Kenneth Francis, LANGER, Seppo W, HASINOFF, Brian B

“…The study was undertaken to determine the metabolism of dexrazoxane (ICRF-187) to its one-ring open hydrolysis products and its two-rings opened…”
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Pharmacokinetics of etoposide in cancer patients treated with high-dose etoposide and with dexrazoxane (ICRF-187) as a rescue agent by SCHROEDER, Patricia E, HOFLAND, Kenneth Francis, JENSEN, Peter Buhl, SEHESTED, Maxwell, LANGER, Seppo W, HASINOFF, Brian B

“…The pharmacokinetics of etoposide were studied in cancer patients with brain metastases treated with high-dose etoposide in order to determine if the…”
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A quantitative correlation study of individualism-collectivism and employee innovation in Turkey by Schroeder, Patricia E

“…Innovation has been positively linked to the economic growth of nations, regions, and organizations. Making employee creativity and innovation actionable at…”
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Metabolism of the doxorubicin cardioprotective agent dexrazoxane and its one ring-opened intermediates B and C to ADR-925 by Schroeder, Patricia E

“…Doxorubicin is one of the most effective chemotherapeutic agents available and has gained widespread use in the treatment of numerous solid tumors and…”
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METABOLISM OF THE CARDIOPROTECTIVE DRUG DEXRAZOXANE AND ONE OF ITS METABOLITES BY ISOLATED RAT MYOCYTES, HEPATOCYTES, AND BLOOD by Schroeder, Patricia E., Wang, Gu-Qi, Burczynski, Frank J., Hasinoff, Brian B.

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