Search Results - "SCHREIBER, Karin"

Structure-guided engineering of the affinity and specificity of CARs against Tn-glycopeptides by Sharma, Preeti, Marada, Venkata V. V. R., Cai, Qi, Kizerwetter, Monika, He, Yanran, Wolf, Steven P., Schreiber, Karin, Clausen, Henrik, Schreiber, Hans, Kranz, David M.

“…The potency of adoptive T cell therapies targeting the cell surface antigen CD19 has been demonstrated in hematopoietic cancers. It has been difficult to…”
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IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner by Liu, Rebecca Berlant, Engels, Boris, Schreiber, Karin, Ciszewski, Cezary, Schietinger, Andrea, Schreiber, Hans, Jabri, Bana

“…A major challenge of cancer immunotherapy is the persistence and outgrowth of subpopulations that lose expression of the target antigen. IL-15 is a potent…”
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Cooperation of genes in HPV16 E6/E7-dependent cervicovaginal carcinogenesis trackable by endoscopy and independent of exogenous estrogens or carcinogens by Böttinger, Paula, Schreiber, Karin, Hyjek, Elizabeth, Krausz, Thomas, Spiotto, Michael T, Steiner, Madeline, Idel, Christian, Booras, Heather, Beck-Engeser, Gabriele, Riederer, Jessie, Willimsky, Gerald, Wolf, Steven P, Karrison, Theodore, Jensen, Elizabeth, Weichselbaum, Ralph R, Nakamura, Yusuke, Yew, Poh Yin, Lambert, Paul F, Kurita, Takeshi, Kiyotani, Kazuma, Leisegang, Matthias, Schreiber, Hans

“…Abstract Human papillomavirus (HPV) infection is necessary but insufficient for progression of epithelial cells from dysplasia to carcinoma-in situ (CIS) to…”
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Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors by Schreiber, Karin, Karrison, Theodore G, Wolf, Steven P, Kiyotani, Kazuma, Steiner, Madeline, Littmann, Eric R, Pamer, Eric G, Kammertoens, Thomas, Schreiber, Hans, Leisegang, Matthias

“…Burnet postulated that the diversity of T-cell receptors (TCR) allows T cells to protect against the development of cancers that display antigens with a…”
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Densely Granulated Murine NK Cells Eradicate Large Solid Tumors by LIU, Rebecca B, ENGELS, Boris, JABRI, Bana, SCHREIBER, Hans, ARINA, Ainhoa, SCHREIBER, Karin, HYJEK, Elizabeth, SCHIETINGER, Andrea, BINDER, David C, BUTZ, Eric, KRAUSZ, Thomas, ROWLEY, Donald A

“…Natural killer (NK) cells inhibit early stages of tumor formation, recurrence, and metastasis. Here, we show that NK cells can also eradicate large solid…”
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Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model by Ranoa, Diana Rose E, Sharma, Preeti, Schane, Claire P, Lewis, Amber N, Valdez, Edward, Marada, Venkata V V R, Hager, Marlies V, Montgomery, Will, Wolf, Steven P, Schreiber, Karin, Schreiber, Hans, Bailey, Keith, Fan, Timothy M, Hergenrother, Paul J, Roy, Edward J, Kranz, David M

“…BackgroundTreatment of some blood cancers with T cells that express a chimeric antigen receptor (CAR) against CD19 have shown remarkable results. In contrast,…”
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Multiple cancer-specific antigens are targeted by a chimeric antibody receptor on a single cancer cell by He, Yanran, Schreiber, Karin, Wolf, Steven P., Wen, Frank, Steentoft, Catharina, Zerweck, Jonathan, Steiner, Madeline, Sharma, Preeti, Shepard, H. Michael, Posey, Avery, June, Carl H., Mandel, Ulla, Clausen, Henrik, Leisegang, Matthias, Meredith, Stephen C., Kranz, David M., Schreiber, Hans

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Assessment of coronary flow reserve: comparison between contrast-enhanced magnetic resonance imaging and positron emission tomography by Ibrahim, Tareq, Nekolla, Stephan G., Schreiber, Karin, Odaka, Kenichi, Volz, Stefan, Mehilli, Julinda, Güthlin, Martin, Delius, Wolfram, Schwaiger, Markus

“…The study compared flow reserve indices by magnetic resonance imaging (MRI) with quantitative measures of coronary angiography and positron emission tomography…”
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Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma by Posey, Avery D., Schwab, Robert D., Boesteanu, Alina C., Steentoft, Catharina, Mandel, Ulla, Engels, Boris, Stone, Jennifer D., Madsen, Thomas D., Schreiber, Karin, Haines, Kathleen M., Cogdill, Alexandria P., Chen, Taylor J., Song, Decheng, Scholler, John, Kranz, David M., Feldman, Michael D., Young, Regina, Keith, Brian, Schreiber, Hans, Clausen, Henrik, Johnson, Laura A., June, Carl H.

“…Genetically modified T cells expressing chimeric antigen receptors (CARs) demonstrate robust responses against lineage restricted, non-essential targets in…”
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Bystander killing of cancer requires the cooperation of CD4(+) and CD8(+) T cells during the effector phase by Schietinger, Andrea, Philip, Mary, Liu, Rebecca B, Schreiber, Karin, Schreiber, Hans

“…Cancers frequently evade cytotoxic T lymphocyte-mediated destruction through loss or down-regulation of tumor antigens and antigen-presenting major…”
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One CD4+TCR and One CD8+TCR Targeting Autochthonous Neoantigens Are Essential and Sufficient for Tumor Eradication by Wolf, Steven P, Anastasopoulou, Vasiliki, Drousch, Kimberley, Diehl, Markus I, Engels, Boris, Yew, Poh Yin, Kiyotani, Kazuma, Nakamura, Yusuke, Schreiber, Karin, Schreiber, Hans, Leisegang, Matthias

“…To achieve eradication of solid tumors, we examined how many neoantigens need to be targeted with how many T-cell receptors (TCR) by which type of T cells…”
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Eradication of Large Solid Tumors by Gene Therapy with a T-Cell Receptor Targeting a Single Cancer-Specific Point Mutation by Leisegang, Matthias, Engels, Boris, Schreiber, Karin, Yew, Poh Yin, Kiyotani, Kazuma, Idel, Christian, Arina, Ainhoa, Duraiswamy, Jaikumar, Weichselbaum, Ralph R, Uckert, Wolfgang, Nakamura, Yusuke, Schreiber, Hans

“…Cancers usually contain multiple unique tumor-specific antigens produced by single amino acid substitutions (AAS) and encoded by somatic nonsynonymous single…”
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Tracking the Common Ancestry of Antigenically Distinct Cancer Variants by SCHREIBER, Karin, WU, Terry H, KAST, W. Martin, SCHREIBER, Hans

“…In the months and years after first diagnosis, cancers often show an increase in their malignancy such as faster growth, resistance to chemo- and/or hormonal…”
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E-102 Destruction of the tumor microenvironment by neoantigen-specific T cells prevents relapse of therapy-resistant cancer variants by Wolf, Steven, Schreiber, Karin, Steiner, Madeline, Weichselbaum, Ralph, Leisegang, Matthias, Schreiber, Hans

“…Microorganisms frequently escape host defenses by generating heritable variants. Cancer cells replicate more slowly than most microorganisms, but variants…”
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Abstract 3238: Engineering chimeric antigen receptors for adoptive T cell therapy of cancers that express the Tn antigen by Sharma, Preeti, Marada, Venkata VVR, Kizerwetter, Monika, Schane, Claire P., He, Yanran, Wolf, Steven P., Schreiber, Karin, Roy, Edward J., Clausen, Henrik, Schreiber, Hans, Kranz, David M.

“…Chimeric antigen receptors (CARs) have shown remarkable promise in treating hematological malignancies, especially those expressing CD19 antigen. On the other…”
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Abstract 3587: TCR-transduced T cells targeting a truncal mutation caused by a nsSNV destroy large solid tumors despite intratumoral genetic heterogeneity by Leisegang, Matthias, Schreiber, Karin, Wolf, Steven P., Anastosopolou, Vasiliki, Borutta, Kimberley, Yew, PohYin, Kiyotani, Kazuma, Nakamura, Yusuke, Schreiber, Hans

“…Most if not all cancers have individually specific, so-called unique antigens that we discovered in 1995 to be caused by somatic tumor-specific, non-synonymous…”
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Spleen Cells from Young Donors Eradicate Large Tumors–Response by Rowley, Donald A., Schreiber, Karin, Schreiber, Hans

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CD4 + T cells with convergent TCR recombination reprogram stroma and halt tumor progression in adoptive therapy by Wolf, Steven P, Leisegang, Matthias, Steiner, Madeline, Wallace, Veronika, Kiyotani, Kazuma, Hu, Yifei, Rosenberger, Leonie, Huang, Jun, Schreiber, Karin, Nakamura, Yusuke, Schietinger, Andrea, Schreiber, Hans

“…Cancers eventually kill hosts even when infiltrated by cancer-specific T cells. We examined whether cancer-specific T cell receptors of CD4 T cells (CD4TCRs)…”
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Abstract LB073: Adoptive transfer of one CD4TCR and one CD8TCR targeting autochthonous neoantigens are essential and sufficient for eradication of naturally heterogeneous solid tumors by Wolf, Steven, Anastasopoulou, Vasiliki, Drousch, Kimberley, Diehl, Markus, Engels, Boris, Yew, Poh Yin, Kiyotani, Kazuma, Nakamura, Yusuke, Schreiber, Karin, Schreiber, Hans, Leisegang, Matthias

“…Despite advances in checkpoint blockade therapy or adoptive transfer of tumor-infiltrating lymphocytes (TILs), achieving cure remains challenging, but success…”
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Transfer of Allogeneic CD4+ T Cells Rescues CD8+ T Cells in Anti-PD-L1-Resistant Tumors Leading to Tumor Eradication by Arina, Ainhoa, Karrison, Theodore, Galka, Eva, Schreiber, Karin, Weichselbaum, Ralph R, Schreiber, Hans

“…Adoptively transferred CD8 T cells can stabilize the size of solid tumors over long periods of time by exclusively recognizing antigen cross-presented on tumor…”
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