Search Results - "SCHREIBER, Hans"

Fibroblasts: Dangerous travel companions by Schreiber, Hans

“…In this issue of , Gao et al. (https://doi.org/10.1084/jem.20180765) demystify the exceptional metastatic success of ovarian cancer, the most lethal female…”
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Structure-guided engineering of the affinity and specificity of CARs against Tn-glycopeptides by Sharma, Preeti, Marada, Venkata V. V. R., Cai, Qi, Kizerwetter, Monika, He, Yanran, Wolf, Steven P., Schreiber, Karin, Clausen, Henrik, Schreiber, Hans, Kranz, David M.

“…The potency of adoptive T cell therapies targeting the cell surface antigen CD19 has been demonstrated in hematopoietic cancers. It has been difficult to…”
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The terminology issue for myeloid-derived suppressor cells by Gabrilovich, Dmitry I, Bronte, Vincenzo, Chen, Shu-Hsia, Colombo, Mario P, Ochoa, Augusto, Ostrand-Rosenberg, Suzanne, Schreiber, Hans

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Inflammation as a tumor promoter in cancer induction by Philip, Mary, Rowley, Donald A., Schreiber, Hans

“…Opposing effects of inflammation on cancer have been described. Acute inflammation usually counteracts cancer development, while chronic inflammation promotes…”
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Relapse or Eradication of Cancer Is Predicted by Peptide-Major Histocompatibility Complex Affinity by Engels, Boris, Engelhard, Victor H., Sidney, John, Sette, Alessandro, Binder, David C., Liu, Rebecca B., Kranz, David M., Meredith, Stephen C., Rowley, Donald A., Schreiber, Hans

“…Cancers often relapse after adoptive therapy, even though specific T cells kill cells from the same cancer efficiently in vitro. We found that tumor…”
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IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner by Liu, Rebecca Berlant, Engels, Boris, Schreiber, Karin, Ciszewski, Cezary, Schietinger, Andrea, Schreiber, Hans, Jabri, Bana

“…A major challenge of cancer immunotherapy is the persistence and outgrowth of subpopulations that lose expression of the target antigen. IL-15 is a potent…”
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Signal integration: a framework for understanding the efficacy of therapeutics targeting the human EGFR family by Shepard, H Michael, Brdlik, Cathleen M, Schreiber, Hans

“…The human EGFR (HER) family is essential for communication between many epithelial cancer cell types and the tumor microenvironment. Therapeutics targeting the…”
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Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors by Yu, Ping, Lee, Youjin, Liu, Wenhua, Krausz, Thomas, Chong, Anita, Schreiber, Hans, Fu, Yang-Xin

“…Tumor environment can be critical for preventing the immunological destruction of antigenic tumors. We have observed a selective accumulation of CD4(+)CD25(+)…”
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Cooperation of genes in HPV16 E6/E7-dependent cervicovaginal carcinogenesis trackable by endoscopy and independent of exogenous estrogens or carcinogens by Böttinger, Paula, Schreiber, Karin, Hyjek, Elizabeth, Krausz, Thomas, Spiotto, Michael T, Steiner, Madeline, Idel, Christian, Booras, Heather, Beck-Engeser, Gabriele, Riederer, Jessie, Willimsky, Gerald, Wolf, Steven P, Karrison, Theodore, Jensen, Elizabeth, Weichselbaum, Ralph R, Nakamura, Yusuke, Yew, Poh Yin, Lambert, Paul F, Kurita, Takeshi, Kiyotani, Kazuma, Leisegang, Matthias, Schreiber, Hans

“…Abstract Human papillomavirus (HPV) infection is necessary but insufficient for progression of epithelial cells from dysplasia to carcinoma-in situ (CIS) to…”
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A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs) by Stone, Jennifer D., Aggen, David H., Schietinger, Andrea, Schreiber, Hans, Kranz, David M.

“…Although T cells can mediate potent antitumor responses, immune tolerance mechanisms often result in the deletion or inactivation of T cells that express…”
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Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors by Schreiber, Karin, Karrison, Theodore G, Wolf, Steven P, Kiyotani, Kazuma, Steiner, Madeline, Littmann, Eric R, Pamer, Eric G, Kammertoens, Thomas, Schreiber, Hans, Leisegang, Matthias

“…Burnet postulated that the diversity of T-cell receptors (TCR) allows T cells to protect against the development of cancers that display antigens with a…”
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Densely Granulated Murine NK Cells Eradicate Large Solid Tumors by LIU, Rebecca B, ENGELS, Boris, JABRI, Bana, SCHREIBER, Hans, ARINA, Ainhoa, SCHREIBER, Karin, HYJEK, Elizabeth, SCHIETINGER, Andrea, BINDER, David C, BUTZ, Eric, KRAUSZ, Thomas, ROWLEY, Donald A

“…Natural killer (NK) cells inhibit early stages of tumor formation, recurrence, and metastasis. Here, we show that NK cells can also eradicate large solid…”
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Antibody recognition of a unique tumor-specific glycopeptide antigen by Brooks, Cory L, Schietinger, Andrea, Borisova, Svetlana N, Kufer, Peter, Okon, Mark, Hirama, Tomoko, MacKenzie, C. Roger, Wang, Lai-Xi, Schreiber, Hans, Evans, Stephen V

“…Aberrant glycosylation and the overexpression of certain carbohydrate moieties is a consistent feature of cancers, and tumor-associated oligosaccharides are…”
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The role of stroma in immune recognition and destruction of well-established solid tumors by Yu, Ping, Rowley, Donald A, Fu, Yang-Xin, Schreiber, Hans

“…Well-established solid tumors (at least 14 days old and >1 cm in average diameter) are extremely difficult to eradicate immunologically in mice. Most cancer…”
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Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model by Ranoa, Diana Rose E, Sharma, Preeti, Schane, Claire P, Lewis, Amber N, Valdez, Edward, Marada, Venkata V V R, Hager, Marlies V, Montgomery, Will, Wolf, Steven P, Schreiber, Karin, Schreiber, Hans, Bailey, Keith, Fan, Timothy M, Hergenrother, Paul J, Roy, Edward J, Kranz, David M

“…BackgroundTreatment of some blood cancers with T cells that express a chimeric antigen receptor (CAR) against CD19 have shown remarkable results. In contrast,…”
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Multiple cancer-specific antigens are targeted by a chimeric antibody receptor on a single cancer cell by He, Yanran, Schreiber, Karin, Wolf, Steven P., Wen, Frank, Steentoft, Catharina, Zerweck, Jonathan, Steiner, Madeline, Sharma, Preeti, Shepard, H. Michael, Posey, Avery, June, Carl H., Mandel, Ulla, Clausen, Henrik, Leisegang, Matthias, Meredith, Stephen C., Kranz, David M., Schreiber, Hans

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Targeting the Primary Tumor to Generate CTL for the Effective Eradication of Spontaneous Metastases by Yu, Ping, Lee, Youjin, Wang, Yang, Liu, Xiaojuan, Auh, Sogyong, Gajewski, Thomas F, Schreiber, Hans, You, Zhaoyang, Kaynor, Campbell, Wang, Xinzhong, Fu, Yang-Xin

“…Metastatic disease is the major cause of morbidity and mortality in cancer. Although surgery, chemotherapy, or radiation can often control primary tumor…”
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A systematic analysis of experimental immunotherapies on tumors differing in size and duration of growth by Wen, Frank T., Thisted, Ronald A., Rowley, Donald A., Schreiber, Hans

“…We conducted a systematic analysis to determine the reason for the apparent disparity of success of immunotherapy between clinical and experimental cancers. To…”
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Increasing Tumor Antigen Expression Overcomes “Ignorance” to Solid Tumors via Crosspresentation by Bone Marrow-Derived Stromal Cells by Spiotto, Michael T., Yu, Ping, Rowley, Donald A., Nishimura, Michael I., Meredith, Stephen C., Gajewski, Thomas F., Fu, Yang-Xin, Schreiber, Hans

“…To explain why solid cancers grow or are rejected, we examined how the tumor stroma affected the level of antigen expression necessary to induce an immune…”
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CD4+ T Cells Eliminate MHC Class II-Negative Cancer Cells in vivo by Indirect Effects of IFN-γ by Mumberg, Dominik, Monach, Paul A., Wanderling, Sherry, Philip, Mary, Toledano, Alicia Y., Schreiber, Robert D., Schreiber, Hans

“…CD4+ T cells can eliminate tumor cells in vivo in the absence of CD8+ T cells. We have CD4+ T cells specific for a MHC class II-restricted, tumor-specific…”
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