Plasmapheresis-induced remission in otherwise therapy-resistant FSGS

Plasmapheresis-induced remission in otherwise therapy-resistant FSGS

We report an 8-year-old Caucasian boy who presented with steroid-resistant nephrotic syndrome. Renal biopsy showed the cellular variant of focal segmental glomerulosclerosis (FSGS). Within 1 year he received a series of therapies that have induced remission in other patients with this disease, all t...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) Vol. 16; no. 11; pp. 898 - 900
Main Authors: VECSEI, Andreas K. W, MÜLLER, Thomas, SCHRATZBERGER, Edith C, KIRCHER, Karl, REGELE, Heinz, ARBEITER, Klaus, SCHROTH, Brigitte, AUFRICHT, Christoph
Format: Conference Proceeding Journal Article
Language:English
Published: Heidelberg Springer 01-11-2001
Springer Nature B.V
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Child
Cyclosporine - administration & dosage
Cyclosporine - therapeutic use
Dose-Response Relationship, Drug
Drug Resistance
Emergency and intensive care: renal failure. Dialysis management
Glomerulosclerosis, Focal Segmental - therapy
Glucocorticoids - therapeutic use
Humans
Immunosuppressive Agents - administration & dosage
Immunosuppressive Agents - therapeutic use
Intensive care medicine
Male
Medical sciences
Methylprednisolone - therapeutic use
Mycophenolic Acid - analogs & derivatives
Mycophenolic Acid - therapeutic use
Plasmapheresis
Remission Induction
Human
Kidney disease
Case study
Corticosteroid
Focal glomerulonephritis
Chemotherapy
Treatment resistance
Urinary system disease
Treatment
Methylprednisolone
Child
Plasmapheresis
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Description
Summary:We report an 8-year-old Caucasian boy who presented with steroid-resistant nephrotic syndrome. Renal biopsy showed the cellular variant of focal segmental glomerulosclerosis (FSGS). Within 1 year he received a series of therapies that have induced remission in other patients with this disease, all to no avail (conventional-dose cyclosporin A, methylprednisolone pulse therapy, high-dose cyclosporin A, and therapy with mycophenolate mofetil). He achieved remission after five sessions of plasma exchange. This case argues for aggressive therapy of resistant nephrotic syndrome in the native kidney. Plasma exchange should be considered as a possible rescue therapy arm in future study protocols.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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ISSN:0931-041X
1432-198X
DOI:10.1007/s004670100682