Pharmacokinetics of carbetocin, a long-acting oxytocin analogue, following intravenous administration in horses

Summary Reason for performing study: Current therapy protocols to treat persistent post mating endometritis and retained fetal membranes in mares typically include the administration of ecbolic drugs. Evaluation of the pharmacokinetics and tolerability of carbetocin, a long‐acting oxytocin analogue,...

Full description

Saved in:

Bibliographic Details
Published in:	Equine veterinary journal Vol. 40; no. 7; pp. 658 - 661
Main Authors:	SCHRAMME, A. R., PINTO, C. R. F., DAVIS, J., WHISNANT, C. S., WHITACRE, M. D.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-11-2008
Subjects:	Animals Area Under Curve carbetocin Female Half-Life Heart Rate - drug effects horse Horse Diseases - blood Horse Diseases - drug therapy Horses - blood Injections, Intravenous - veterinary oxytocin Oxytocin - adverse effects Oxytocin - analogs & derivatives Oxytocin - pharmacokinetics Oxytocin - therapeutic use Pain - chemically induced Pain - epidemiology Pain - veterinary pharmacokinetics Radioimmunoassay - veterinary Respiration - drug effects
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Summary Reason for performing study: Current therapy protocols to treat persistent post mating endometritis and retained fetal membranes in mares typically include the administration of ecbolic drugs. Evaluation of the pharmacokinetics and tolerability of carbetocin, a long‐acting oxytocin analogue, after i.v. administration is required. Objectives: To determine the pharmacokinetic parameters (principally half‐life) of carbetocin in horses. Methods: Five mature mares and one gelding received 0.175 mg carbetocin i.v. All animals were monitored periodically throughout the study for elevation in rectal temperature, heart rate, respiratory rate and signs of pain or discomfort. Plasma samples were collected for determination of carbetocin concentrations by radioimmunoassay. Results: Administration of carbetocin was well tolerated by all horses and its half‐life was 17.2 min. Conclusions: The half‐life of carbetocin is greater than that previously reported for oxytocin (6.8 min). Potential relevance: Carbetocin is an attractive alternative to oxytocin therapy in broodmare management.
Bibliography:	ArticleID:EVJ455 istex:296B6064885E0D04FE88B6609C92FE9BA6A1F778 ark:/67375/WNG-CRRXR6JK-Z ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0425-1644 2042-3306
DOI:	10.2746/042516408X334343