Search Results - "SCHOUSBOE, ARNE"

Astrocytic Metabolism Focusing on Glutamate Homeostasis: A Short Review Dedicated to Vittorio Gallo by Schousboe, Arne

“…A large number of studies have during the last several decades shown that astrocytes play a significant role in brain energy metabolism accounting for a…”
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Preface for the Vittorio Gallo Honorary Issue of Neurochemical Research by Schousboe, Arne

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Preface for the Vladimir Parpura Honorary Issue of Neurochemical Research by Verkhratsky, Alexei, Schousboe, Arne, Zorec, Robert

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Astrocytic glycogen metabolism in the healthy and diseased brain by Bak, Lasse K., Walls, Anne B., Schousboe, Arne, Waagepetersen, Helle S.

“…The brain contains a fairly low amount of glycogen, mostly located in astrocytes, a fact that has prompted the suggestion that glycogen does not have a…”
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The glutamate/GABA‐glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer by Bak, Lasse K., Schousboe, Arne, Waagepetersen, Helle S.

“…Neurons are metabolically handicapped in the sense that they are not able to perform de novo synthesis of neurotransmitter glutamate and γ‐aminobutyric acid…”
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Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease by Andersen, Jens V., Christensen, Sofie K., Westi, Emil W., Diaz-delCastillo, Marta, Tanila, Heikki, Schousboe, Arne, Aldana, Blanca I., Waagepetersen, Helle S.

“…Alzheimer's disease (AD) leads to cerebral accumulation of insoluble amyloid-β plaques causing synaptic dysfunction and neuronal death. Neurons rely on…”
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Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease by Andersen, Jens V., Skotte, Niels H., Christensen, Sofie K., Polli, Filip S., Shabani, Mohammad, Markussen, Kia H., Haukedal, Henriette, Westi, Emil W., Diaz-delCastillo, Marta, Sun, Ramon C., Kohlmeier, Kristi A., Schousboe, Arne, Gentry, Matthew S., Tanila, Heikki, Freude, Kristine K., Aldana, Blanca I., Mann, Matthias, Waagepetersen, Helle S.

“…Alzheimer’s disease (AD) is an unremitting neurodegenerative disorder characterized by cerebral amyloid-β (Aβ) accumulation and gradual decline in cognitive…”
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Glial cells in (patho)physiology by Parpura, Vladimir, Heneka, Michael T., Montana, Vedrana, Oliet, Stéphane H. R., Schousboe, Arne, Haydon, Philip G., Stout Jr, Randy F., Spray, David C., Reichenbach, Andreas, Pannicke, Thomas, Pekny, Milos, Pekna, Marcela, Zorec, Robert, Verkhratsky, Alexei

“…J. Neurochem. (2012) 121, 4–27. Neuroglial cells define brain homeostasis and mount defense against pathological insults. Astroglia regulate neurogenesis and…”
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Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating by Kristensen, Anders S, Jenkins, Meagan A, Banke, Tue G, Schousboe, Arne, Makino, Yuichi, Johnson, Richard C, Huganir, Richard, Traynelis, Stephen F

“…CaMKII phosphorylates the GluA1 AMPA subunit at Ser831 to increase single channel conductance. Here, the authors show that coexpression of TARPs is required…”
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Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease by Salcedo, Claudia, Wagner, Antonie, Andersen, Jens V., Vinten, Kasper Tore, Waagepetersen, Helle S., Schousboe, Arne, Freude, Kristine K., Aldana, Blanca I.

“…Alterations in neurotransmitter homeostasis, primarily of glutamate and GABA, is strongly implicated in the pathophysiology of Alzheimer’s disease (AD)…”
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Structural and molecular aspects of betaine-GABA transporter 1 (BGT1) and its relation to brain function by Kickinger, Stefanie, Hellsberg, Eva, Frølund, Bente, Schousboe, Arne, Ecker, Gerhard F., Wellendorph, Petrine

“…ɣ-aminobutyric-acid (GABA) functions as the principal inhibitory neurotransmitter in the central nervous system. Imbalances in GABAergic neurotransmission are…”
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Astrocytic Control of Biosynthesis and Turnover of the Neurotransmitters Glutamate and GABA by Schousboe, Arne, Bak, Lasse K, Waagepetersen, Helle S

“…Glutamate and GABA are the quantitatively major neurotransmitters in the brain mediating excitatory and inhibitory signaling, respectively. These amino acids…”
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Glutamate and GABA synthesis, release, transport and metabolism as targets for seizure control by Rowley, Nicole M., Madsen, Karsten K., Schousboe, Arne, Steve White, H.

“…► Synthesis, packaging, release, and termination of neurotransmitters alter activity. ► Metabolizing enzymes and membrane transporters are integral therapeutic…”
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Role of astrocytes in the maintenance and modulation of glutamatergic and GABAergic neurotransmission by SCHOUSBOE, Arne

“…The functional activity in the brain is primarily composed of an interplay between excitation and inhibition. In any given region the output is based upon a…”
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Delineation of the Role of Astroglial GABA Transporters in Seizure Control by Schousboe, Arne, Madsen, Karsten K.

“…Studies of GABA transport in neurons and astrocytes have provided evidence that termination of GABA as neurotransmitter is brought about primarily by active…”
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Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects by Lie, Maria E. K., Kickinger, Stefanie, Skovgaard-Petersen, Jonas, Ecker, Gerhard F., Clausen, Rasmus P., Schousboe, Arne, White, H. Steve, Wellendorph, Petrine

“…Focal epileptic seizures can in some patients be managed by inhibiting γ-aminobutyric acid (GABA) uptake via the GABA transporter 1 (GAT1) using tiagabine…”
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The Transcriptome and Metabolic Gene Signature of Protoplasmic Astrocytes in the Adult Murine Cortex by Lovatt, Ditte, Sonnewald, Ursula, Waagepetersen, Helle S, Schousboe, Arne, He, Wei, Lin, Jane H.-C, Han, Xiaoning, Takano, Takahiro, Wang, Su, Sim, Fraser J, Goldman, Steven A, Nedergaard, Maiken

“…Protoplasmic astrocytes are critically important to energy metabolism in the CNS. Our current understanding of the metabolic interactions between neurons and…”
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Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: Current evidence and pharmacological tools by McKenna, Mary C., Waagepetersen, Helle S., Schousboe, Arne, Sonnewald, Ursula

“…The malate–aspartate shuttle and the glycerol phosphate shuttle act to transfer reducing equivalents from NADH in the cytosol to the mitochondria since the…”
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Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia by Voss, Caroline M., Arildsen, Lene, Nissen, Jakob D., Waagepetersen, Helle S., Schousboe, Arne, Maechler, Pierre, Ott, Peter, Vilstrup, Hendrik, Walls, Anne B.

“…Impaired liver function may lead to hyperammonemia and risk for hepatic encephalopathy. In brain, detoxification of ammonia is mediated mainly by glutamine…”
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Functional significance of brain glycogen in sustaining glutamatergic neurotransmission by Sickmann, Helle M, Walls, Anne B, Schousboe, Arne, Bouman, Stephan D, Waagepetersen, Helle S

“…The involvement of brain glycogen in sustaining neuronal activity has previously been demonstrated. However, to what extent energy derived from glycogen is…”
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