Search Results - "SCHOTT, Herbert"

Liposome Formulations of Hydrophobic Drugs by Schwendener, Reto A, Schott, Herbert

“…Here we report methods of preparation for liposome formulations containing lipophilic drugs. In contrast to the encapsulation of water soluble compounds into…”
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Heterodinucleoside Phosphates of 5-Fluorodeoxyuridine and Arabinofuranosylcytosine - New Drugs in Cancer Chemotherapy? by Saiko, Philipp, Horvath, Zsuzsanna, Jaeger, Walter, Schott, Herbert, Fritzer-Szekeres, Monika, Szekeres, Thomas

“…The incidence of cancer is rapidly increasing and malignancies have become the number two cause of deaths in the Western world after cardiovascular diseases…”
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N 4-[Alkyl-(hydroxyphosphono)phosphonate]-cytidine—New drugs covalently linking antimetabolites (5-FdU, araU or AZT) with bone-targeting bisphosphonates (alendronate or pamidronate) by Schott, Herbert, Goltz, Daniel, Schott, Timm C., Jauch, Claudia, Schwendener, Reto A.

“…New cytostatic antimetabolite-bisphosphonates. Amino-bisphosphonates (alendronate, pamidronate) were covalently linked in a three step synthesis, with…”
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Synthesis and in vitro activities of new anticancer duplex drugs linking 2′-deoxy-5-fluorouridine (5-FdU) with 3′- C-ethynylcytidine (ECyd) via a phosphodiester bonding by Schott, Herbert, Schott, Sarah, Schwendener, Reto A.

“…Antitumor active duplex drugs linking 2′-deoxy-5-fluorouridine with 3′- C-ethynylcytidine via a 5′→5′ (A) or a 3′→5′ (B) phosphodiester bonding. Two isomeric…”
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Liposome formulations of hydrophobic drugs by Schwendener, Reto A, Schott, Herbert

“…Here, we report methods of preparation for liposome formulations containing lipophilic drugs. In contrast to the encapsulation of water-soluble compounds into…”
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Cytostatic Activity of a 5-Fluoro-2'-deoxyuridine―Alendronate Conjugate against Gastric Adenocarcinoma and Non-malignant Intestinal and Fibroblast Cell Lines by WEINREICH, Jurgen, SCHOTT, Timm C, KÖNIGSRAINER, Ingmar, KÜPER, Markus, KÖNIGSRAINER, Alfred, SCHOTT, Herbert

“…5-Fluoro-2'-deoxyuridine (5-FdU), a drug against gastric cancer, was covalently linked via its nucleobase with the amino-bisphosphonate alendronate (Ale),…”
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Cytostatic activity of the duplex drug linking 2′-deoxy-5-fluorouridine (5FdU) with 3′-C-ethynylcytidine (ECyd) against gastric adenocarcinoma cell lines by Weinreich, Jürgen, Schott, Sarah, Königsrainer, Ingmar, Zieker, Derek, Königsrainer, Alfred, Schott, Herbert

“…Summary The cytostatic potential of the new duplex drug 2′-deoxy-5-fluorouridylyl-(5′➔5′)-3′-C-ethynylcytidine (5FdU(5′-5′)ECyd) was evaluated in comparison to…”
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N super(4)-[Alkyl-(hydroxyphosphono)phosphonate]-cytidine - New drugs covalently linking antimetabolites (5-FdU, araU or AZT) with bone-targeting bisphosphonates (alendronate or pamidronate) by Schott, Herbert, Goltz, Daniel, Schott, Timm C, Jauch, Claudia, Schwendener, Reto A

“…Amino-bisphosphonates (alendronate, pamidronate) were covalently linked in a three step synthesis, with protected and triazolylated derivatives of…”
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N4-[Alkyl-(hydroxyphosphono)phosphonatel-cytidine―New drugs covalently linking antimetabolites (5-FdU, araU or AZT) with bone-targeting bisphosphonates (alendronate or pamidronate) by SCHOTT, Herbert, GOLTZ, Daniel, SCHOTT, Timm C, JAUCH, Claudia, SCHWENDENER, Reto A

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Isolation and characterization of a scFv antibody specific for tumor endothelial marker 1 (TEM1), a new reagent for targeted tumor therapy by Marty, Cornelia, Langer-Machova, Zuzana, Sigrist, Sandra, Schott, Herbert, Schwendener, Reto A., Ballmer-Hofer, Kurt

“…Tumor endothelial marker 1 (TEM1) is a protein predominantly expressed on the cell surface of endothelial cells in newly developing blood vessels and on tumor…”
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N⁴-[Alkyl-(hydroxyphosphono)phosphonate]-cytidine—New drugs covalently linking antimetabolites (5-FdU, araU or AZT) with bone-targeting bisphosphonates (alendronate or pamidronate) by Schott, Herbert, Goltz, Daniel, Schott, Timm C, Jauch, Claudia, Schwendener, Reto A

“…Amino-bisphosphonates (alendronate, pamidronate) were covalently linked in a three step synthesis, with protected and triazolylated derivatives of…”
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Effects of ring substituents on the type II photoreactions of phenyl ketones. How interactions between nearby excited triplets affect chemical reactivity by Wagner, Peter J, Kemppainen, Allen E, Schott, Herbert N

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Synthesis and in vitro activities of a new antiviral duplex drug linking Zidovudine (AZT) and Foscarnet (PFA) via an octadecylglycerol residue by Schott, Herbert, Hamprecht, Klaus, Schott, Sarah, Schott, Timm C., Schwendener, Reto A.

“…To prepare a new antiviral duplex drug linking Zidovudine (AZT) and Foscarnet (PFA) via a lipophilic octadecylglycerol residue we condensed 1-…”
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Cellular pharmacology of multi- and duplex drugs consisting of ethynylcytidine and 5-fluoro-2'-deoxyuridine by Bijnsdorp, Irene V, Schwendener, Reto A, Schott, Herbert, Fichtner, Iduna, Smid, Kees, Laan, Adrie C, Schott, Sarah, Losekoot, Nienke, Honeywell, Richard J, Peters, Godefridus J

“…Prodrugs can have the advantage over parent drugs in increased activation and cellular uptake. The multidrug ETC-L-FdUrd and the duplex drug ETC-FdUrd are…”
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Cellular pharmacology of multi- and duplex drugsconsisting of ethynylcytidine and 5-fluoro-2′-deoxyuridine by Bijnsdorp, Irene V., Schwendener, Reto A., Schott, Herbert, Fichtner, Iduna, Smid, Kees, Laan, Adrie C., Schott, Sarah, Losekoot, Nienke, Honeywell, Richard J., Peters, Godefridus J.

“…Summary Prodrugs can have the advantage over parent drugs in increased activation and cellular uptake. The multidrug ETC-L-FdUrd and the duplex drug ETC-FdUrd…”
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Synthesis and anticancer activities of amphiphilic 5-fluoro-2′-deoxyuridylic acid prodrugs by Ludwig, Peter S., Schwendener, Reto A., Schott, Herbert

“…Amphiphilic anticancer prodrugs of 5′-fluoro-2′-deoxyuridine-5′-monophosphate (5-FdUMP) were synthesized according to the hydrogen phosphonate method by…”
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5-FdUrd–araC heterodinucleoside re-establishes sensitivity in 5-FdUrd- and AraC-resistant MCF-7 breast cancer cells overexpressing ErbB2 by Strasser, Stephen, Maier, Susanne, Leisser, Christina, Saiko, Philipp, Madlener, Sibylle, Bader, Yvonne, Bernhaus, Astrid, Gueorguieva, Marieta, Richter, Susanne, Mader, Robert M., Wesierska-Gadek, Jozefa, Schott, Herbert, Szekeres, Thomas, Fritzer-Szekeres, Monika, Krupitza, Georg

“…ErbB2 overexpressing breast tumors have a poor prognosis and a high risk to develop chemoresistance to therapeutic treatment. “Chemoresistance” is a response…”
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Separation and sequencing of the sequence isomers of pyrimidine deoxypentanucleoside tetraphosphates by high-performance liquid chromatography by Dizdaroglu, M, Simic, M G, Schott, H

“…Chemical synthesis of DNA fragments with a defined sequence is extremely long and complex. A simpler alternative is isolation of fragments from partially…”
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Dihydroxyboryl-substituted methacrylic polymer for the column chromatographic separation of mononucleotides, oligonucleotides, and transfer ribonucleic acid by Schott, Herbert, Rudloff, Eberhard, Schmidt, Peter, Roychoudhury, Ranajit, Koessel, Hans

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Lipophilic arabinofuranosyl cytosine derivatives in liposomes by Schwendener, Reto, Schott, Herbert

“…Highly lipophilic drugs can be used therapeutically only by the addition of possibly toxic solubilizing agents or by development of complex pharmaceutical…”
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