Search Results - "SCHOENECKER, Jonathan G"

The multifaceted role of fibrinogen in tissue injury and inflammation by Luyendyk, James P., Schoenecker, Jonathan G., Flick, Matthew J.

“…The canonical role of the hemostatic and fibrinolytic systems is to maintain vascular integrity. Perturbations in either system can prompt primary pathological…”
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Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study by Coupland, Lucy A, Rabbolini, David J, Schoenecker, Jonathan G, Crispin, Philip J, Miller, Jennene J, Ghent, Tony, Medcalf, Robert L, Aneman, Anders E

“…Fibrinolysisis is essential for vascular blood flow maintenance and is triggered by endothelial and platelet release of tissue plasminogen activator (t-PA). In…”
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Advancing Tissue Factor-targeted Therapy for Osteosarcoma via Understanding its Role in the Tumor Microenvironment by Ichikawa, Jiro, Schoenecker, Jonathan G, Tatsuno, Rikito, Kawasaki, Tomonori, Suzuki-Inoue, Katsue, Haro, Hirotaka

“…Coagulation activation is associated with cancer progression and morbidity. Recently, mechanisms through which coagulation proteases drive the tumor…”
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Albumin and the fibrinogen-to-albumin ratio: Biomarkers for the acute phase response following total knee arthroplasty by Amaro, Emilie, Moore-Lotridge, Stephanie N, Wessinger, Bronson, Benvenuti, Michael A, An, Thomas J, Oelsner, William K, Polkowski, Gregory G, Schoenecker, Jonathan G

“…Complications following total knee arthroplasty (TKA) lead to patient morbidity and cost. While acute phase reactants, such as c-reactive protein (CRP) and…”
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Bisphosphonates Inhibit Osteosarcoma‐Mediated Osteolysis Via Attenuation of Tumor Expression of MCP‐1 and RANKL by Ohba, Tetsuro, Cole, Heather A, Cates, Justin MM, Slosky, David A, Haro, Hirotaka, Ando, Takashi, Schwartz, Herbert S, Schoenecker, Jonathan G

“…ABSTRACT Osteosarcoma is the most common primary malignant tumor of bone and accounts for around 50% of all primary skeletal malignancies. In addition to novel…”
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Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification by Yuasa, Masato, Mignemi, Nicholas A, Nyman, Jeffry S, Duvall, Craig L, Schwartz, Herbert S, Okawa, Atsushi, Yoshii, Toshitaka, Bhattacharjee, Gourab, Zhao, Chenguang, Bible, Jesse E, Obremskey, William T, Flick, Matthew J, Degen, Jay L, Barnett, Joey V, Cates, Justin M M, Schoenecker, Jonathan G

“…Bone formation during fracture repair inevitably initiates within or around extravascular deposits of a fibrin-rich matrix. In addition to a central role in…”
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Micro-computed tomography assessment of the progression of fracture healing in mice by O'Neill, Kevin R, Stutz, Christopher M, Mignemi, Nicholas A, Burns, Michael C, Murry, Matthew R, Nyman, Jeffry S, Schoenecker, Jonathan G

“…Abstract The mouse fracture model is ideal for research into the pathways of healing because of the availability of genetic and transgenic mice and the ability…”
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Plasmin Prevents Dystrophic Calcification After Muscle Injury by Mignemi, Nicholas A, Yuasa, Masato, Baker, Courtney E, Moore, Stephanie N, Ihejirika, Rivka C, Oelsner, William K, Wallace, Christopher S, Yoshii, Toshitaka, Okawa, Atsushi, Revenko, Alexey S, MacLeod, A Robert, Bhattacharjee, Gourab, Barnett, Joey V, Schwartz, Herbert S, Degen, Jay L, Flick, Matthew J, Cates, Justin M, Schoenecker, Jonathan G

“…ABSTRACT Extensive or persistent calcium phosphate deposition within soft tissues after severe traumatic injury or major orthopedic surgery can result in pain…”
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Unexpected timely fracture union in matrix metalloproteinase 9 deficient mice by Yuasa, Masato, Saito, Masanori, Molina, Cesar, Moore-Lotridge, Stephanie N, Benvenuti, Michael A, Mignemi, Nicholas A, Okawa, Atsushi, Yoshii, Toshitaka, Schwartz, Herbert S, Nyman, Jeffry S, Schoenecker, Jonathan G

“…Immediately following a fracture, a fibrin laden hematoma is formed to prevent bleeding and infection. Subsequently, the organized removal of fibrin, via the…”
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Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion by Raghu, Harini, Cruz, Carolina, Rewerts, Cheryl L., Frederick, Malinda D., Thornton, Sherry, Mullins, Eric S., Schoenecker, Jonathan G., Degen, Jay L., Flick, Matthew J.

“…Rheumatoid arthritis is a chronic inflammatory disease characterized by synovial hyperplasia, inflammatory cell infiltration, irreversible cartilage and bone…”
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Thrombin induced by the extrinsic pathway and PAR-1 regulated inflammation at the site of fracture repair by Sato, Nobutaka, Ichikawa, Jiro, Wako, Masanori, Ohba, Tetsuro, Saito, Masanori, Sato, Hironao, Koyama, Kensuke, Hagino, Tetsuo, Schoenecker, Jonathan G, Ando, Takashi, Haro, Hirotaka

“…Abstract Thrombin (coagulation factor IIa) is a serine protease encoded by the F2 gene. Pro-thrombin (coagulation factor II) is cut to generate thrombin in the…”
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Cyclic bisphosphonate therapy reduces pain and improves physical functioning in children with osteogenesis imperfecta by Garganta, Melissa D, Jaser, Sarah S, Lazow, Margot A, Schoenecker, Jonathan G, Cobry, Erin, Hays, Stephen R, Simmons, Jill H

“…Children with osteogenesis imperfecta (OI) experience pain and impaired physical functioning. The longitudinal effect of cyclic bisphosphonate treatment on…”
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Fibrin Accumulation Secondary to Loss of Plasmin‐Mediated Fibrinolysis Drives Inflammatory Osteoporosis in Mice by Cole, Heather A., Ohba, Tetsuro, Nyman, Jeffry S., Hirotaka, Haro, Cates, Justin M. M., Flick, Matthew J., Degen, Jay L., Schoenecker, Jonathan G.

“…Objective Osteoporosis is a skeletal disorder characterized by low bone mass and increased bone fragility associated with aging, menopause, smoking, obesity,…”
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Validation of a Radiography-Based Quantification Designed to Longitudinally Monitor Soft Tissue Calcification in Skeletal Muscle by Moore, Stephanie N, Hawley, Gregory D, Smith, Emily N, Mignemi, Nicholas A, Ihejirika, Rivka C, Yuasa, Masato, Cates, Justin M M, Liu, Xulei, Schoenecker, Jonathan G

“…Soft tissue calcification, including both dystrophic calcification and heterotopic ossification, may occur following injury. These lesions have variable fates…”
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Characterizing the Acute Phase Response in Healthy Patients Following Total Joint Arthroplasty: Predictable and Consistent by Oelsner, William K., BS, Engstrom, Stephen M., MD, Benvenuti, Michael A., BS, An, Thomas J., AB, Jacobson, Richard A., MD, Polkowski, Gregory G., MD MSc, Schoenecker, Jonathan G., MD PhD

“…Abstract Background During surgery, trauma to musculoskeletal tissue induces a systemic reaction known as the acute phase response (APR). When excessive or…”
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Proximal location in extremity long bones is a poor prognostic factor for osteosarcoma: A retrospective cohort study of 153 patients by Cates, Justin M M, Schoenecker, Jonathan G

“…Osteosarcomas arising in the proximal femur, humerus, and tibia appear to have poorer outcomes than those arising in distal long bones. However, the strength…”
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Trauma-Induced Nanohydroxyapatite Deposition in Skeletal Muscle is Sufficient to Drive Heterotopic Ossification by Moore-Lotridge, Stephanie N., Li, Qiaoli, Gibson, Breanne H. Y., Martin, Joseph T., Hawley, Gregory D., Arnold, Thomas H., Saito, Masanori, Tannouri, Sami, Schwartz, Herbert S., Gumina, Richard J., Cates, Justin M. M., Uitto, Jouni, Schoenecker, Jonathan G.

“…Heterotopic ossification (HO), or the pathologic formation of bone within soft tissues, is a significant complication following severe injuries as it impairs…”
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Pleiotropic effects of bisphosphonates on osteosarcoma by Ohba, Tetsuro, Cates, Justin M.M, Cole, Heather A, Slosky, David A, Haro, Hirotaka, Ichikawa, Jiro, Ando, Takashi, Schwartz, Herbert S, Schoenecker, Jonathan G

“…Abstract Osteosarcoma is the most common primary malignant tumor of bone and accounts for half of all primary skeletal malignancies in children and teenagers…”
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The Size of Intramedullary Fixation Affects Endochondral-Mediated Angiogenesis During Fracture Repair by Yuasa, Masato, Saito, Masanori, Blum, Deke M, Hysong, Alexander A, Egawa, Satoru, Uppuganti, Sasidhar, Yoshii, Toshitaka, Okawa, Atsushi, Schwartz, Herbert S, Moore-Lotridge, Stephanie N, Nyman, Jeffry S, Schoenecker, Jonathan G

“…OBJECTIVES:To explore the effect of intramedullary pin size on the biology of a healing fracture, specifically endochondral angiogenesis. We hypothesized that…”
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Head and Neck Necrotizing Fasciitis: Abbreviated SOFA Score Associated With Death and Infection Spread by Vittetoe, Kelly L., Johnson, Samuel R., Benvenuti, Teresa A., Schoenecker, Jonathan G., Moore‐Lotridge, Stephanie N., Rohde, Sarah L.

“…Objective Describe features unique to head and neck (H&N) necrotizing fasciitis (NF) compared to other anatomic regions and specify a prognostic score…”
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