Search Results - "SCHOEFFTER, Philippe"

Functional activity of the multiligand analog SOM230 at human recombinant somatostatin receptor subtypes supports its usefulness in neuroendocrine tumors by Schmid, Herbert A, Schoeffter, Philippe

“…Functional gastroenteropancreatic tumors express all 5 somatostatin receptor subtypes (sst) in different quantities. Octreotide and lanreotide treat patients…”
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Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors by MAHE, Cécile, LOETSCHER, Erika, FEUERBACH, Dominik, MÜLLER, Werner, SEILER, Max P, SCHOEFFTER, Philippe

“…Recombinant 5-hydroxytryptamine 5-HT7 receptors are known to express constitutive, i.e., agonist-independent activity. Nonselective ligands, like methiothepin,…”
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NGD 94-1 as an agonist at human recombinant dopamine D4.4 receptors expressed in HEK293 cells by GAZI, L, SOMMER, B, NOZULAK, J, SCHOEFFTER, P

“…The atypical antipsychotic, clozapine has some selectivity for dopamine D4 receptors and is a silent antagonist at these receptors. NGD 94-1…”
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Functional expression of the serotonin 5‐HT 7 receptor in human glioblastoma cell lines by Mahé, Cécile, Bernhard, Michel, Bobirnac, Ionel, Keser, Corinna, Loetscher, Erika, Feuerbach, Dominik, Dev, Kumlesh K, Schoeffter, Philippe

“…Serotonin 5‐HT 7 receptors are present in astrocytes. Understanding their role in this type of cell would greatly benefit from the identification of astroglial…”
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Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst(3) receptor antagonists by Troxler, Thomas, Hurth, Konstanze, Schuh, Karl-Heinrich, Schoeffter, Philippe, Langenegger, Daniel, Enz, Albert, Hoyer, Daniel

“…Starting from non-peptidic sst(1)-selective somatostatin receptor antagonists, first compounds with mixed sst(1)/sst(3) affinity were identified by directed…”
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Distinct functional properties of native somatostatin receptor subtype 5 compared with subtype 2 in the regulation of ACTH release by corticotroph tumor cells by van der Hoek, Joost, Waaijers, Marlijn, van Koetsveld, Peter M, Sprij-Mooij, Diana, Feelders, Richard A, Schmid, Herbert A, Schoeffter, Philippe, Hoyer, Daniel, Cervia, Davide, Taylor, John E, Culler, Michael D, Lamberts, Steven W J, Hofland, Leo J

“…In a series of human corticotroph adenomas, we recently found predominant mRNA expression of somatostatin (SS) receptor subtype 5 (sst5). After 72 h, the…”
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Modulatory role of the vascular endothelium in the contractility of human isolated internal mammary artery by Schoeffter, Philippe, Dion, Robert, Godfraind, Théophile

“…1 Endothelium‐dependent relaxant responses and modulation of contractile responses were investigated in human isolated internal mammary artery (HIMA), a vessel…”
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Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst3 receptor antagonists by TROXLER, Thomas, HURTH, Konstanze, SCHUH, Karl-Heinrich, SCHOEFFTER, Philippe, LANGENEGGER, Daniel, ENZ, Albert, HOYER, Daniel

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Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608) by Spooren, Will P.J.M, Schoeffter, Philippe, Gasparini, Fabrizio, Kuhn, Rainer, Gentsch, Conrad

“…The stress-induced hyperthermia test is a paradigm developed several years ago to model the expression of autonomic hyperactivity in anxiety. Whereas in the…”
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Discovery of novel non-peptidic beta-alanine piperazine amide derivatives and their optimization to achiral, easily accessible, potent and selective somatostatin sst1 receptor antagonists by Troxler, Thomas, Hurth, Konstanze, Mattes, Henri, Prashad, Mahavir, Schoeffter, Philippe, Langenegger, Daniel, Enz, Albert, Hoyer, Daniel

“…Structural simplification of the core moieties of obeline and ergoline somatostatin sst(1) receptor antagonists, followed by systematic optimization, led to…”
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Serotonin 5-HT7 receptors coupled to induction of interleukin-6 in human microglial MC-3 cells by Mahé, Cécile, Loetscher, Erika, Dev, Kumlesh K, Bobirnac, Ionel, Otten, Uwe, Schoeffter, Philippe

“…Brain serotonin 5-HT(7) receptors are known to be expressed in neurons and astrocytes. We now report the presence of these receptors in a third type of cell,…”
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Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst sub(3) receptor antagonists by Troxler, Thomas, Hurth, Konstanze, Schuh, Karl-Heinrich, Schoeffter, Philippe, Langenegger, Daniel, Enz, Albert, Hoyer, Daniel

“…Starting from non-peptidic sst sub(1)-selective somatostatin receptor antagonists, first compounds with mixed sst sub(1)/sst sub(3) affinity were identified by…”
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Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst 3 receptor antagonists by Troxler, Thomas, Hurth, Konstanze, Schuh, Karl-Heinrich, Schoeffter, Philippe, Langenegger, Daniel, Enz, Albert, Hoyer, Daniel

“…Starting from non-peptidic sst 1-selective somatostatin receptor antagonists, first compounds with mixed sst 1/sst 3 affinity were identified by directed…”
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Functional characterization of the novel antipsychotic iloperidone at human D2, D3, α2C, 5-HT6, and 5-HT1A receptors by Kalkman, Hans O, Feuerbach, Dominik, Lötscher, Erika, Schoeffter, Philippe

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Ergoline derivatives as highly potent and selective antagonists at the somatostatin sst1 receptor by TROXLER, Thomas, ENZ, Albert, HOYER, Daniel, LANGENEGGER, Daniel, NEUMANN, Peter, PFÄFFLI, Paul, SCHOEFFTER, Philippe, HURTH, Konstanze

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Toward Selective ERβ Agonists for Central Nervous System Disorders:  Synthesis and Characterization of Aryl Benzthiophenes by Schopfer, Ulrich, Schoeffter, Philippe, Bischoff, Serge F, Nozulak, Joachim, Feuerbach, Dominik, Floersheim, Philipp

“…In an effort to identify selective ligands for the estrogen receptor subtype ERβ, a series of aryl benzthiophenes was synthesized. In a radioligand binding…”
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Functional characterisation of the putative somatostatin sst2 receptor antagonist CYN 154806 by Nunn, Caroline, Schoeffter, Philippe, Langenegger, Daniel, Hoyer, Daniel

“…The two forms (DTyr8 and LTyr8) of the putative somatostatin sst2 receptor antagonist CYN 154806 (Ac-4NO2-Phe-c(DCys-Tyr-DTrp-Lys-Thr-Cys)-D/LTyr-NH2) were…”
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Discovery of novel non-peptidic β-alanine piperazine amide derivatives and their optimization to achiral, easily accessible, potent and selective somatostatin sst 1 receptor antagonists by Troxler, Thomas, Hurth, Konstanze, Mattes, Henri, Prashad, Mahavir, Schoeffter, Philippe, Langenegger, Daniel, Enz, Albert, Hoyer, Daniel

“…Pharmacophore considerations based on obeline and ergoline somatostatin sst 1 receptor antagonists led to the design of an achiral β-alanine piperazine amide…”
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Functional expression of the serotonin 5‐HT7 receptor in human glioblastoma cell lines by Mahé, Cécile, Bernhard, Michel, Bobirnac, Ionel, Keser, Corinna, Loetscher, Erika, Feuerbach, Dominik, Dev, Kumlesh K, Schoeffter, Philippe

“…Serotonin 5‐HT7 receptors are present in astrocytes. Understanding their role in this type of cell would greatly benefit from the identification of astroglial…”
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Age-related decrease of in vitro isoproterenol-induced cyclic AMP accumulation in rat aorta by Schoeffter, P, Stoclet, J C

“…Isoproterenol-induced accumulation of cyclic AMP was investigated in aorta rings from 7 to 18 weeks old rats. The effect of isoproterenol on cyclic AMP reached…”
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