Search Results - "SCHMIDT, Eric W."

The polyketide to fatty acid transition in the evolution of animal lipid metabolism by Lin, Zhenjian, Li, Feng, Krug, Patrick J., Schmidt, Eric W.

“…Animals synthesize simple lipids using a distinct fatty acid synthase (FAS) related to the type I polyketide synthase (PKS) enzymes that produce complex…”
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Translating Marine Symbioses toward Drug Development by Schmidt, Eric W, Lin, Zhenjian

“…Chemists have studied marine animals for the better part of a century because they contain a diverse array of bioactive compounds. Tens of thousands of…”
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Genome‐Mining‐Based Discovery of the Cyclic Peptide Tolypamide and TolF, a Ser/Thr Forward O‐Prenyltransferase by Purushothaman, Mugilarasi, Sarkar, Snigdha, Morita, Maho, Gugger, Muriel, Schmidt, Eric W., Morinaka, Brandon I.

“…Cyanobactins comprise a widespread group of peptide metabolites produced by cyanobacteria that are often diversified by post‐translational prenylation. Several…”
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Trading molecules and tracking targets in symbiotic interactions by Schmidt, Eric W

“…It is probable that nearly every natural product structure results from interactions between organisms. Symbiosis, a subset of inter-organism interactions…”
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Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges by Agarwal, Vinayak, Blanton, Jessica M, Podell, Sheila, Taton, Arnaud, Schorn, Michelle A, Busch, Julia, Lin, Zhenjian, Schmidt, Eric W, Jensen, Paul R, Paul, Valerie J, Biggs, Jason S, Golden, James W, Allen, Eric E, Moore, Bradley S

“…Metagenomic analysis and functional characterization of biosynthetic genes uncovers the basis for widespread polybrominated diphenyl ether biosynthesis in…”
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The Biochemistry and Structural Biology of Cyanobactin Pathways: Enabling Combinatorial Biosynthesis by Gu, Wenjia, Dong, Shi-Hui, Sarkar, Snigdha, Nair, Satish K, Schmidt, Eric W

“…Cyanobactin biosynthetic enzymes have exceptional versatility in the synthesis of natural and unnatural products. Cyanobactins are ribosomally synthesized and…”
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Animal biosynthesis of complex polyketides in a photosynthetic partnership by Torres, Joshua P., Lin, Zhenjian, Winter, Jaclyn M., Krug, Patrick J., Schmidt, Eric W.

“…Complex polyketides are typically associated with microbial metabolism. Here, we report that animals also make complex, microbe-like polyketides. We show there…”
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Roads to Rome: Role of Multiple Cassettes in Cyanobactin RiPP Biosynthesis by Gu, Wenjia, Sardar, Debosmita, Pierce, Elizabeth, Schmidt, Eric W

“…Ribosomally synthesized and post-translationally modified peptides (RiPPs) are ubiquitous natural products. Bioactive RiPPs are produced from a precursor…”
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Accessing chemical diversity from the uncultivated symbionts of small marine animals by Smith, Thomas E, Pond, Christopher D, Pierce, Elizabeth, Harmer, Zachary P, Kwan, Jason, Zachariah, Malcolm M, Harper, Mary Kay, Wyche, Thomas P, Matainaho, Teatulohi K, Bugni, Tim S, Barrows, Louis R, Ireland, Chris M, Schmidt, Eric W

“…A combination of spectroscopy, metagenomics, and synthetic biology enables the characterization of the antiviral divamides, a class of lanthipeptide natural…”
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Enzymatic N- and C‑Protection in Cyanobactin RiPP Natural Products by Sardar, Debosmita, Hao, Yue, Lin, Zhenjian, Morita, Maho, Nair, Satish K, Schmidt, Eric W

“…Recent innovations in peptide natural product biosynthesis reveal a surprising wealth of previously uncharacterized biochemical reactions that have potential…”
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A Single Amino Acid Switch Alters the Isoprene Donor Specificity in Ribosomally Synthesized and Post-Translationally Modified Peptide Prenyltransferases by Estrada, Paola, Morita, Maho, Hao, Yue, Schmidt, Eric W, Nair, Satish K

“…Mutation at a single amino acid alters the isoprene donor specificity of prenyltransferases involved in the modification of ribosomally synthesized and…”
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Genome streamlining and chemical defense in a coral reef symbiosis by Kwan, Jason C, Donia, Mohamed S, Han, Andrew W, Hirose, Euichi, Haygood, Margo G, Schmidt, Eric W

“…Secondary metabolites are ubiquitous in bacteria, but by definition, they are thought to be nonessential. Highly toxic secondary metabolites such as…”
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Combinatorialization of Fungal Polyketide Synthase–Peptide Synthetase Hybrid Proteins by Kakule, Thomas B, Lin, Zhenjian, Schmidt, Eric W

“…The programming of the fungal polyketide synthase (PKS) is quite complex, with a simple domain architecture leading to elaborate products. An additional level…”
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Enzymatic Basis of Ribosomal Peptide Prenylation in Cyanobacteria by McIntosh, John A, Donia, Mohamed S, Nair, Satish K, Schmidt, Eric W

“…The enzymatic basis of ribosomal peptide natural product prenylation has not been reported. Here, we characterize a prenyltransferase, LynF, from the TruF…”
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Post-Translational Tyrosine Geranylation in Cyanobactin Biosynthesis by Morita, Maho, Hao, Yue, Jokela, Jouni K, Sardar, Debosmita, Lin, Zhenjian, Sivonen, Kaarina, Nair, Satish K, Schmidt, Eric W

“…Prenylation is a widespread modification that improves the biological activities of secondary metabolites. This reaction also represents a key modification…”
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Secondary Metabolites of the Genus Didemnum : A Comprehensive Review of Chemical Diversity and Pharmacological Properties by Youssef, Diaa T A, Almagthali, Hadeel, Shaala, Lamiaa A, Schmidt, Eric W

“…Tunicates (ascidians) are common marine invertebrates that are an exceptionally important source of natural products with biomedical and pharmaceutical…”
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Molecular basis of pigment structural diversity in echinoderms by Li, Feng, Lin, Zhenjian, Schmidt, Eric W.

“…The varied pigments found in animals play both ecological and physiological roles. Virtually all echinoderms contain putative pigment biosynthetic enzymes, the…”
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Pyrrolocin C and equisetin inhibit bacterial acetyl-CoA carboxylase by Larson, Erica C, Lim, Albebson L, Pond, Christopher D, Craft, Matthew, Čavužić, Mirela, Waldrop, Grover L, Schmidt, Eric W, Barrows, Louis R

“…Antimicrobial resistance is a growing global health and economic concern. Current antimicrobial agents are becoming less effective against common bacterial…”
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Molecular basis for the broad substrate selectivity of a peptide prenyltransferase by Hao, Yue, Pierce, Elizabeth, Roe, Daniel, Morita, Maho, McIntosh, John A., Agarwal, Vinayak, Cheatham, Thomas E., Schmidt, Eric W., Nair, Satish K.

“…The cyanobactin prenyltransferases catalyze a series of known or unprecedented reactions onmillions of different substrates, with no easily observable…”
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Bacterial endosymbiosis in a chordate host: long-term co-evolution and conservation of secondary metabolism by Kwan, Jason C, Schmidt, Eric W

“…Intracellular symbiosis is known to be widespread in insects, but there are few described examples in other types of host. These symbionts carry out useful…”
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