Search Results - "SCHMIDT, Alexander C"

Immunogenicity and Safety of 3 Formulations of a Respiratory Syncytial Virus Candidate Vaccine in Nonpregnant Women: A Phase 2, Randomized Trial by Schwarz, Tino F, McPhee, Roderick A, Launay, Odile, Leroux-Roels, Geert, Talli, Jaak, Picciolato, Marta, Gao, Feng, Cai, Rongman, Nguyen, Thi Lien-Anh, Dieussaert, Ilse, Miller, Jacqueline M, Schmidt, Alexander C

“…Abstract Background Respiratory syncytial virus (RSV) is a common cause of respiratory tract illness and hospitalization in neonates and infants. RSV…”
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Safety and Immunogenicity of 3 Formulations of an Investigational Respiratory Syncytial Virus Vaccine in Nonpregnant Women: Results From 2 Phase 2 Trials by Beran, Jiři, Lickliter, Jason D, Schwarz, Tino F, Johnson, Casey, Chu, Laurence, Domachowske, Joseph B, Van Damme, Pierre, Withanage, Kanchanamala, Fissette, Laurence A, David, Marie-Pierre, Maleux, Koen, Schmidt, Alexander C, Picciolato, Marta, Dieussaert, Ilse

“…A single dose of either 30 µg or 60 µg of nonadjuvanted respiratory syncytial virus prefusion F protein antigen boosts humoral immune responses in women of…”
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Development of standard clinical endpoints for use in dengue interventional trials by Tomashek, Kay M, Wills, Bridget, See Lum, Lucy Chai, Thomas, Laurent, Durbin, Anna, Leo, Yee-Sin, de Bosch, Norma, Rojas, Elsa, Hendrickx, Kim, Erpicum, Martin, Agulto, Liane, Jaenisch, Thomas, Tissera, Hasitha, Suntarattiwong, Piyarat, Collers, Beth Ann, Wallace, Derek, Schmidt, Alexander C, Precioso, Alexander, Narvaez, Federico, Thomas, Stephen J, Edelman, Robert, Siqueira, João Bosco, Cassetti, M Cristina, Dempsey, Walla, Gubler, Duane J

“…Dengue is a major public health problem worldwide. Although several drug candidates have been evaluated in randomized controlled trials, none has been…”
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Pathogenesis of acute respiratory illness caused by human parainfluenza viruses by Schomacker, Henrick, Schaap-Nutt, Anne, Collins, Peter L, Schmidt, Alexander C

“…► HPIVs evade the innate immune response and replicate efficiently in respiratory epithelium. ► Cellular pathology in ex vivo epithelium is limited. ► Previous…”
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End-point definition and trial design to advance tuberculosis vaccine development by Garcia-Basteiro, Alberto L, White, Richard G, Tait, Dereck, Schmidt, Alexander C, Rangaka, Molebogeng X, Quaife, Matthew, Nemes, Elisa, Mogg, Robin, Hill, Philip C, Harris, Rebecca C, Hanekom, Willem A, Frick, Mike, Fiore-Gartland, Andrew, Evans, Tom, Dagnew, Alemnew F, Churchyard, Gavin, Cobelens, Frank, Behr, Marcel A, Hatherill, Mark

“…Tuberculosis (TB) remains a leading infectious cause of death worldwide and the coronavirus disease 2019 pandemic has negatively impacted the global TB burden…”
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The C proteins of human parainfluenza virus type 1 block IFN signaling by binding and retaining Stat1 in perinuclear aggregates at the late endosome by Schomacker, Henrick, Hebner, Rebecca M, Boonyaratanakornkit, Jim, Surman, Sonja, Amaro-Carambot, Emerito, Collins, Peter L, Schmidt, Alexander C

“…Interferons (IFNs) play a crucial role in the antiviral immune response. Whereas the C proteins of wild-type human parainfluenza virus type 1 (WT HPIV1)…”
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Data-driven epidemiologic approach to conducting site feasibility for a global phase III tuberculosis vaccine clinical trial by Mui, Wai-Ling, Parekh, Falgunee K., Tseng, Ashley S., Toro, Joy, Craig, Taylor, Ndugga, Maggwa, Schmidt, Alexander C., Dagnew, Alemnew F., Penz, Craig, Belai, Ghiorghis

“…An efficacious tuberculosis (TB) vaccine is critical to reducing the global burden of TB. TB vaccine trials require the identification of multiple sites…”
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Characterization of B-cell and T-cell responses to a tetravalent dengue purified inactivated vaccine in healthy adults by Friberg, Heather, Gargulak, Morgan, Kong, Amanda, Lin, Leyi, Martinez, Luis J., Schmidt, Alexander C., Paris, Robert M., Jarman, Richard G., Diaz, Clemente, Thomas, Stephen J., Moris, Philippe, Currier, Jeffrey R.

“…The increasing global impact of dengue underscores the need for a dengue virus (DENV) vaccine. We assessed B-cell and T-cell responses following vaccination…”
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Dengue illness index-A tool to characterize the subjective dengue illness experience by Thomas, Stephen J, Agulto, Liane, Hendrickx, Kim, Erpicum, Martin, Tomashek, Kay M, Cassetti, M Cristina, Laughlin, Catherine, Precioso, Alexander, Schmidt, Alexander C, Narvaez, Federico, Siqueira, João Bosco, Tissera, Hasitha, Edelman, Robert

“…Dengue virus infections are a major cause of febrile illness that significantly affects individual and societal productivity and drives up health care costs…”
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A single dose of the DENV-1 candidate vaccine rDEN1Δ30 is strongly immunogenic and induces resistance to a second dose in a randomized trial by Durbin, Anna P, Whitehead, Stephen S, Shaffer, Donna, Elwood, Dan, Wanionek, Kimberli, Thumar, Bhavin, Blaney, Joseph E, Murphy, Brian R, Schmidt, Alexander C

“…Dengue is an emerging infectious disease that has become the most important arboviral infection worldwide. There are four serotypes of dengue virus, DENV-1,…”
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Phase 1 Trial of the Dengue Virus Type 4 Vaccine Candidate rDEN4Δ30-4995 in Healthy Adult Volunteers by WRIGHT, Peter F, DURBIN, Anna P, MURPHY, Brian R, SCHMIDT, Alexander C, WHITEHEAD, Stephen S, IKIZLER, Mine R, HENDERSON, Susan, BLANEY, Joseph E, THUMAR, Bhavin, ANKRAH, Sharon, ROCK, Michael T, MCKINNEY, Brett A

“…rDEN4Δ30-4995 is a live attenuated dengue virus type 4 (DENV4) vaccine candidate specifically designed as a further attenuated derivative of the rDEN4Δ30…”
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Identification of Human Parainfluenza Virus Type 2 (HPIV-2) V Protein Amino Acid Residues That Reduce Binding of V to MDA5 and Attenuate HPIV-2 Replication in Nonhuman Primates by SCHAAP-NUTT, Anne, HIGGINS, Caraline, AMARO-CARAMBOT, Emerito, NOLAN, Sheila M, D'ANGELO, Christopher, MURPHY, Brian R, COLLINS, Peter L, SCHMIDT, Alexander C

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Response to Dengue Fever — The Good, the Bad, and the Ugly? by Schmidt, Alexander C

“…Severe dengue has been attributed to antibody-dependent enhancement during a second infection with dengue virus. A recent study provides evidence for, and an…”
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Human parainfluenza virus type 2 V protein inhibits interferon production and signaling and is required for replication in non-human primates by Schaap-Nutt, Anne, D'Angelo, Christopher, Scull, Margaret A, Amaro-Carambot, Emerito, Nishio, Machiko, Pickles, Raymond J, Collins, Peter L, Murphy, Brian R, Schmidt, Alexander C

“…Abstract In wild-type human parainfluenza virus type 2 (WT HPIV2), one gene (the P/V gene) encodes both the polymerase-associated phosphoprotein (P) and the…”
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Human Parainfluenza Virus Type 1 C Proteins Are Nonessential Proteins That Inhibit the Host Interferon and Apoptotic Responses and Are Required for Efficient Replication in Nonhuman Primates by BARTLETT, Emmalene J, CRUZ, Ann-Marie, MURPHY, Brian R, SCHMIDT, Alexander C, ESKER, Janice, CASTANO, Adam, SCHOMACKER, Henrick, SURMAN, Sonja R, HENNESSEY, Margaret, BOONYARATANAKORNKIT, Jim, PICKLES, Raymond J, COLLINS, Peter L

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Role of Interferon in the Replication of Human Parainfluenza Virus Type 1 Wild Type and Mutant Viruses in Human Ciliated Airway Epithelium by BARTLETT, Emmalene J, HENNESSEY, Margaret, SKIADOPOULOS, Mario H, SCHMIDT, Alexander C, COLLINS, Peter L, MURPHY, Brian R, PICKLES, Raymond J

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The C Proteins of Human Parainfluenza Virus Type 1 (HPIV1) Control the Transcription of a Broad Array of Cellular Genes That Would Otherwise Respond to HPIV1 Infection by BOONYARATANAKORNKIT, Jim B, BARTLETT, Emmalene J, AMARO-CARAMBOT, Emerito, COLLINS, Peter L, MURPHY, Brian R, SCHMIDT, Alexander C

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Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis by Alton, Eric W F W, Beekman, Jeffery M, Boyd, A Christopher, Brand, June, Carlon, Marianne S, Connolly, Mary M, Chan, Mario, Conlon, Sinead, Davidson, Heather E, Davies, Jane C, Davies, Lee A, Dekkers, Johanna F, Doherty, Ann, Gea-Sorli, Sabrina, Gill, Deborah R, Griesenbach, Uta, Hasegawa, Mamoru, Higgins, Tracy E, Hironaka, Takashi, Hyndman, Laura, McLachlan, Gerry, Inoue, Makoto, Hyde, Stephen C, Innes, J Alastair, Maher, Toby M, Moran, Caroline, Meng, Cuixiang, Paul-Smith, Michael C, Pringle, Ian A, Pytel, Kamila M, Rodriguez-Martinez, Andrea, Schmidt, Alexander C, Stevenson, Barbara J, Sumner-Jones, Stephanie G, Toshner, Richard, Tsugumine, Shu, Wasowicz, Marguerite W, Zhu, Jie

“…We have recently shown that non-viral gene therapy can stabilise the decline of lung function in patients with cystic fibrosis (CF). However, the effect was…”
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Phase 1 Randomized Study of a Tetravalent Dengue Purified Inactivated Vaccine in Healthy Adults in the United States by Schmidt, Alexander C, Lin, Leyi, Martinez, Luis J, Ruck, Richard C, Eckels, Kenneth H, Collard, Alix, De La Barrera, Rafael, Paolino, Kristopher M, Toussaint, Jean-François, Lepine, Edith, Innis, Bruce L, Jarman, Richard G, Thomas, Stephen J

“…AbstractThe safety and immunogenicity of four formulations of an investigational tetravalent dengue purified inactivated vaccine (DPIV), formulated at 1 or 4…”
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Development and clinical evaluation of multiple investigational monovalent DENV vaccines to identify components for inclusion in a live attenuated tetravalent DENV vaccine by Durbin, Anna P, Kirkpatrick, Beth D, Pierce, Kristen K, Schmidt, Alexander C, Whitehead, Stephen S

“…Highlights ► Multiple monovalent dengue vaccine candidates were evaluated for safety, immunogenicity, and infectivity. ► The replication kinetics of multiple…”
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