A green method for determination of ethanol in homeopathic medicines using thermal infrared enthalpimetry

A green method for determination of ethanol in homeopathic medicines using thermal infrared enthalpimetry

Abstract In this work, a simple and fast method is proposed for the determination of ethanol in homeopathic medicines using thermal infrared enthalpimetry (TIE). Samples containing alcohol in a wide concentration range (from 5% to 95% v/v) were used. Purified water or absolute ethanol was added dire...

Full description

Saved in:
Bibliographic Details
Published in:Anais da Academia Brasileira de Ciências Vol. 92; no. 3; p. e20181307
Main Authors: SCHLOSSER, KAROLINA C., OLIVEIRA, ALESSANDRA S., FAGUNDES, MARIANE B., WAGNER, ROGER, MELLO, RENIUS O., BARIN, JULIANO S., SILVA, FABIANA E.B. DA
Format: Journal Article
Language:English
Published: Academia Brasileira de Ciências 01-01-2020
Subjects:
alcoholic solutions
green chemistry
MULTIDISCIPLINARY SCIENCES
pharmaceutical
thermography
pharmaceutical
thermography
alcoholic solutions
green chemistry
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract In this work, a simple and fast method is proposed for the determination of ethanol in homeopathic medicines using thermal infrared enthalpimetry (TIE). Samples containing alcohol in a wide concentration range (from 5% to 95% v/v) were used. Purified water or absolute ethanol was added directly into homeopathic medicine and increase of temperature was monitored using an infrared camera. Total volume, stirring speed and dispensing rate of solutions were the most significant parameters studied for method optimization. A response surface methodology (RSM) was used for optimization of the experimental conditions. The method was validated in the following parameters: selectivity, linearity, linear range, precision (repeatability and intermediate precision), limit of detection and quantification, accuracy and robustness. Linear range was obtained from 4% to 55% (ethanol, v/v). The proposed method showed accuracy in agreement with the conventional one. The proposed method it was demonstrated a good alternative for determination of ethanol in homeopathic medicines, presenting low cost, fast analysis and agreement with the principles of green analytical chemistry.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0001-3765
1678-2690
1678-2690
DOI:10.1590/0001-3765202020181307