Search Results - "SCHLOSS, JOHN"

Nutritional deficiencies that may predispose to long COVID by Schloss, John V.

“…Multiple nutritional deficiencies (MND) confound studies designed to assess the role of a single nutrient in contributing to the initiation and progression of…”
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On the origin of cysteamine-induced duodenal cytotoxicity and type II ferroptosis by Schloss, John V., Szabo, Sandor

“…Cysteamine (CA) induces duodenal ulcers in rodents (Selye and Szabo, Nature 244:458–459, 1973). Cysteine (Cys), a precursor for the formation of CA (via…”
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Plant Phenylacetaldehyde Synthase Is a Bifunctional Homotetrameric Enzyme That Catalyzes Phenylalanine Decarboxylation and Oxidation by Kaminaga, Yasuhisa, Schnepp, Jennifer, Peel, Greg, Kish, Christine M., Ben-Nissan, Gili, Weiss, David, Orlova, Irina, Lavie, Orly, Rhodes, David, Wood, Karl, Porterfield, D. Marshall, Cooper, Arthur J.L., Schloss, John V., Pichersky, Eran, Vainstein, Alexander, Dudareva, Natalia

“…We have isolated and characterized Petunia hybrida cv. Mitchell phenylacetaldehyde synthase (PAAS), which catalyzes the formation of phenylacetaldehyde, a…”
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Interaction of the Herbicide Glyphosate with Its Target Enzyme 5-Enolpyruvylshikimate 3-Phosphate Synthase in Atomic Detail by Schönbrunn, Ernst, Eschenburg, Susanne, Shuttleworth, Wendy A., Schloss, John V., Amrhein, Nikolaus, Jeremy N. S. Evans, Kabsch, Wolfgang

“…Biosynthesis of aromatic amino acids in plants, many bacteria, and microbes relies on the enzyme 5-enolpyruvylshikimate 3-phosphate (EPSP) synthase, a prime…”
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The Role of NMDA Receptor Partial Antagonist, Carbamathione, as a Therapeutic Agent for Transient Global Ischemia by Modi, Jigar Pravinchandra, Shen, Wen, Menzie-Suderam, Janet, Xu, Hongyuan, Lin, Chun-Hua, Tao, Rui, Prentice, Howard M, Schloss, John, Wu, Jang-Yen

“…Carbamathione (Carb), an NMDA glutamate receptor partial antagonist, has potent neuroprotective functions against hypoxia- or ischemia-induced neuronal injury…”
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Enzyme-catalyzed side reactions with molecular oxygen may contribute to cell signaling and neurodegenerative diseases by Bunik, Victoria I, Schloss, John V, Pinto, John T, Gibson, Gary E, Cooper, Arthur J L

“…A link between neurodegeneration and well-characterized enzymatic and non-enzymatic reactions that produce reactive oxygen species (ROS) from O(2) is well…”
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Oxygen toxicity from plants to people by Schloss, John V.

“…Over the past 30 years, acute oxygen toxicity in plants, mammals and enteric bacteria has been defined in terms of specific interactions of oxygen with a…”
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Advancements in small molecule drug design: A structural perspective by Wu, Ke, Karapetyan, Eduard, Schloss, John, Vadgama, Jaydutt, Wu, Yong

“…•Importance of accurate protein structure prediction for small molecule drug design.•Key structural features and properties used in small molecule drug…”
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A survey of oxidative paracatalytic reactions catalyzed by enzymes that generate carbanionic intermediates: implications for ROS production, cancer etiology, and neurodegenerative diseases by Bunik, Victoria I, Schloss, John V, Pinto, John T, Dudareva, Natalia, Cooper, Arthur J L

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Significance of slow-binding enzyme inhibition and its relationship to reaction-intermediate analogs by Schloss, John V

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Homology Modeling of the Structure of Bacterial Acetohydroxy Acid Synthase and Examination of the Active Site by Site-Directed Mutagenesis by Ibdah, Muhammad, Bar-Ilan, Ahuva, Livnah, Oded, Schloss, John V, Barak, Ze'ev, Chipman, David M

“…Acetohydroxy acid synthase (AHAS, EC 4.1.3.18) catalyzes the thiamin pyrophosphate (TPP)-dependent decarboxylation of pyruvate and condensation of the…”
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Oxygenase side reactions of acetolactate synthase and other carbanion-forming enzymes by Abell, Lynn M, Schloss, John V

“…Enzymes that mediate carbanion chemistry must protect their reactants from solvent and undesirable electrophiles, such as molecular oxygen. A number of enzymes…”
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Roles of Protein Disulfide Isomerase in Breast Cancer by Yang, Suhui, Jackson, Chanel, Karapetyan, Eduard, Dutta, Pranabananda, Kermah, Dulcie, Wu, Yong, Wu, Yanyuan, Schloss, John, Vadgama, Jaydutt V

“…Protein disulfide isomerase (PDI) is the endoplasmic reticulum (ER)'s most abundant and essential enzyme and serves as the primary catalyst for protein…”
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Oxalyl hydroxamates as reaction-intermediate analogs for ketol-acid reductoisomerase by Aulabaugh, Ann, Schloss, John V

“…N-Hydroxy-N-isopropyloxamate (IpOHA) is an exceptionally potent inhibitor of the Escherichia coli ketol-acid reductoisomerase. In the presence of Mg2+ or Mn2+,…”
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Origin of the herbicide binding site of acetolactate synthase by Schloss, John V, Ciskanik, Lawrence M, Dyk, Drew E.Van

“…A study that proposed that the herbicide-specific site of acetolactate synthase (ALS) is an evolutionary vestige of the quinone binding site of pyruvate…”
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Biosynthesis of 2-aceto-2-hydroxy acids: acetolactate synthases and acetohydroxyacid synthases by Chipman, David, Barak, Ze’ev, Schloss, John V.

“…Two groups of enzymes are classified as acetolactate synthase (EC 4.1.3.18). This review deals chiefly with the FAD-dependent, biosynthetic enzymes which…”
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Association of l-Glutamic Acid Decarboxylase to the 70-kDa Heat Shock Protein as a Potential Anchoring Mechanism to Synaptic Vesicles by Hsu, Che-Chang, Davis, Kathleen M., Jin, Hong, Foos, Todd, Floor, Erik, Chen, Weiqing, Tyburski, John B., Yang, Chao-Yuh, Schloss, John V., Wu, Jang-Yen

“…Recently we have reported that the membrane-associated form of the γ-aminobutyric acid-synthesizing enzyme, l-glutamate decarboxylase (MGAD), is regulated by…”
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Protein Phosphorylation and Taurine Biosynthesis In Vivo and In Vitro by Tang, Xiao Wen, Hsu, Che-Chang, Schloss, John V, Faiman, Morris D, Wu, Elliott, Yang, Chao-Yuh, Wu, Jang-Yen

“…Taurine is known to be involved in many important physiological functions. Here we report that both in vivo and in vitro the taurine-synthesizing enzyme in the…”
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Role of Synaptic Vesicle Proton Gradient and Protein Phosphorylation on ATP-mediated Activation of Membrane-associated Brain Glutamate Decarboxylase by Hsu, Che-Chang, Thomas, Charles, Chen, Weiqing, Davis, Kathleen M., Foos, Todd, Chen, Jeffrey L., Wu, Elliott, Floor, Erik, Schloss, John V., Wu, Jang-Yen

“…Previously, we have shown that the soluble form of brain glutamic acid decarboxylase (GAD) is inhibited by ATP through protein phosphorylation and is activated…”
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PHYSIOLOGICAL PREDICTORS OF LONG-TERM EFFECTS OF COVID-19 IN PATIENTS WITH SARS-COV-2: FOCUS ON LYMPHOCYTE PROLIFERATION-IMPROVING MICRONUTRIENTS by Karkhut, Sofia-Maria, Muzyka, Iryna, Savytska, Maryana, Dzhyoieva, Khrystyna, Pohoretska, Yaryna, Ivanchenko, Nataliya, Zayachkivska, Oksana, Schloss, John V., Szabo, Sandor

“…Patients with long-term effects of coronavirus disease, the so-called “long-term COVID-19 syndrome” (long-COVID-19) after SARS-CoV-2 infection, have a…”
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