Search Results - "SCHLESINGER, S"

Activation of transcription factor CREB in human macrophages by Mycobacterium tuberculosis promotes bacterial survival, reduces NF-kB nuclear transit and limits phagolysosome fusion by reduced necroptotic signaling by Leopold Wager, Chrissy M, Bonifacio, Jordan R, Simper, Jan, Naoun, Adrian A, Arnett, Eusondia, Schlesinger, Larry S

“…Macrophages are a first line of defense against pathogens. However, certain invading microbes modify macrophage responses to promote their own survival and…”
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Innate Immune Gene Polymorphisms in Tuberculosis by AZAD, Abul K, SADEE, Wolfgang, SCHLESINGER, Larry S

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Physical activity and the risk of preterm birth: a systematic review and meta‐analysis of epidemiological studies by Aune, D, Schlesinger, S, Henriksen, T, Saugstad, OD, Tonstad, S

“…Background Physical activity has been inconsistently associated with risk of preterm birth, and the strength of the association and the shape of the…”
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Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice by Oladunni, Fatai S., Park, Jun-Gyu, Pino, Paula A., Gonzalez, Olga, Akhter, Anwari, Allué-Guardia, Anna, Olmo-Fontánez, Angélica, Gautam, Shalini, Garcia-Vilanova, Andreu, Ye, Chengjin, Chiem, Kevin, Headley, Colwyn, Dwivedi, Varun, Parodi, Laura M., Alfson, Kendra J., Staples, Hilary M., Schami, Alyssa, Garcia, Juan I., Whigham, Alison, Platt, Roy Neal, Gazi, Michal, Martinez, Jesse, Chuba, Colin, Earley, Stephanie, Rodriguez, Oscar H., Mdaki, Stephanie Davis, Kavelish, Katrina N., Escalona, Renee, Hallam, Cory R. A., Christie, Corbett, Patterson, Jean L., Anderson, Tim J. C., Carrion, Ricardo, Dick, Edward J., Hall-Ursone, Shannan, Schlesinger, Larry S., Alvarez, Xavier, Kaushal, Deepak, Giavedoni, Luis D., Turner, Joanne, Martinez-Sobrido, Luis, Torrelles, Jordi B.

“…Vaccine and antiviral development against SARS-CoV-2 infection or COVID-19 disease would benefit from validated small animal models. Here, we show that…”
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Diabetes mellitus and the risk of sudden cardiac death: A systematic review and meta-analysis of prospective studies by Aune, D., Schlesinger, S., Norat, T., Riboli, E.

“…Although diabetes mellitus is an established risk factor for myocardial infarction and stroke, data on the association with sudden cardiac death are less…”
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Modeling the Mycobacterium tuberculosis Granuloma - the Critical Battlefield in Host Immunity and Disease by Guirado, Evelyn, Schlesinger, Larry S

“…Granulomas are the hallmark of Mycobacterium tuberculosis (M.tb) infection and thus sit at the center of tuberculosis (TB) immunopathogenesis. TB can result…”
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Impact of diabetes on the natural history of tuberculosis by Restrepo, Blanca I, Schlesinger, Larry S

“…Highlights • The current rise in diabetes mellitus (DM) worldwide has led to the re-emerging importance of DM to tuberculosis control. • We review the impact…”
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Diabetes mellitus, blood glucose and the risk of heart failure: A systematic review and meta-analysis of prospective studies by Aune, D., Schlesinger, S., Neuenschwander, M., Feng, T., Janszky, I., Norat, T., Riboli, E.

“…The strength of the association between diabetes and risk of heart failure has differed between previous studies and the available studies have not been…”
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Modeling Granulomas in Response to Infection in the Lung by Hao, Wenrui, Schlesinger, Larry S, Friedman, Avner

“…Alveolar macrophages play a large role in the innate immune response of the lung. However, when these highly immune-regulatory cells are unable to eradicate…”
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Macrophage nuclear receptors: Emerging key players in infectious diseases by Leopold Wager, Chrissy M, Arnett, Eusondia, Schlesinger, Larry S

“…Nuclear receptors (NRs) are ligand-activated transcription factors that are expressed in a variety of cells, including macrophages. For decades, NRs have been…”
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Dendritic cell-targeted protein vaccines: a novel approach to induce T-cell immunity by Trumpfheller, C., Longhi, M. P., Caskey, M., Idoyaga, J., Bozzacco, L., Keler, T., Schlesinger, S. J., Steinman, R. M.

“…  Trumpfheller C, Longhi MP, Caskey M, Idoyaga J, Bozzacco L, Keler T, Schlesinger SJ, Steinman RM (The Rockefeller University, New York, NY; and Celldex…”
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AmpliSeq transcriptome analysis of human alveolar and monocyte-derived macrophages over time in response to Mycobacterium tuberculosis infection by Papp, Audrey C, Azad, Abul K, Pietrzak, Maciej, Williams, Amanda, Handelman, Samuel K, Igo, Jr, Robert P, Stein, Catherine M, Hartmann, Katherine, Schlesinger, Larry S, Sadee, Wolfgang

“…Human alveolar macrophages (HAM) are primary bacterial niche and immune response cells during Mycobacterium tuberculosis (M.tb) infection, and human blood…”
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Human Genetic Determinants of Viral Diseases by Kenney, Adam D, Dowdle, James A, Bozzacco, Leonia, McMichael, Temet M, St. Gelais, Corine, Panfil, Amanda R, Sun, Yan, Schlesinger, Larry S, Anderson, Matthew Z, Green, Patrick L, López, Carolina B, Rosenberg, Brad R, Wu, Li, Yount, Jacob S

“…Much progress has been made in the identification of specific human gene variants that contribute to enhanced susceptibility or resistance to viral diseases…”
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Current Sarcoidosis Models and the Importance of Focusing on the Granuloma by Locke, Landon W, Schlesinger, Larry S, Crouser, Elliott D

“…The inability to effectively model sarcoidosis in the laboratory or in animals continues to hinder the discovery and translation of new, targeted treatments…”
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Phagocytosis via complement or Fc-gamma receptors is compromised in monocytes from type 2 diabetes patients with chronic hyperglycemia by Restrepo, Blanca I, Twahirwa, Marcel, Rahbar, Mohammad H, Schlesinger, Larry S

“…Type 2 diabetes patients (DM2) have a higher risk of tuberculosis (TB) that may be attributed to functional defects in their mononuclear phagocytes given the…”
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Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization by Akhter, Anwari, Caution, Kyle, Abu Khweek, Arwa, Tazi, Mia, Abdulrahman, Basant A., Abdelaziz, Dalia H.A., Voss, Oliver H., Doseff, Andrea I., Hassan, Hoda, Azad, Abul K., Schlesinger, Larry S., Wewers, Mark D., Gavrilin, Mikhail A., Amer, Amal O.

“…Inflammasomes are multiprotein complexes that include members of the NLR (nucleotide-binding domain leucine-rich repeat containing) family and caspase-1. Once…”
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Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b by Rajaram, Murugesan V. S., Ni, Bin, Morris, Jessica D., Brooks, Michelle N., Carlson, Tracy K., Bakthavachalu, Baskar, Schoenberg, Daniel R., Torrelles, Jordi B., Schlesinger, Larry S.

“…Contact of Mycobacterium tuberculosis (M.tb) with the immune system requires interactions between microbial surface molecules and host pattern recognition…”
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Myeloid cell interferon responses correlate with clearance of SARS-CoV-2 by Singh, Dhiraj K., Aladyeva, Ekaterina, Das, Shibali, Singh, Bindu, Esaulova, Ekaterina, Swain, Amanda, Ahmed, Mushtaq, Cole, Journey, Moodley, Chivonne, Mehra, Smriti, Schlesinger, Larry S., Artyomov, Maxim N., Khader, Shabaana A., Kaushal, Deepak

“…Emergence of mutant SARS-CoV-2 strains associated with an increased risk of COVID-19-related death necessitates better understanding of the early viral…”
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Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection by Sivangala Thandi, Ramya, Radhakrishnan, Rajesh Kumar, Tripathi, Deepak, Paidipally, Padmaja, Azad, Abul K, Schlesinger, Larry S, Samten, Buka, Mulik, Sachin, Vankayalapati, Ramakrishna

“…Macrophages are professional phagocytes known to play a vital role in controlling Mycobacterium tuberculosis (Mtb) infection and disease progression. Here we…”
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PPARγ is critical for Mycobacterium tuberculosis induction of Mcl-1 and limitation of human macrophage apoptosis by Arnett, Eusondia, Weaver, Ashlee M, Woodyard, Kiersten C, Montoya, Maria J, Li, Michael, Hoang, Ky V, Hayhurst, Andrew, Azad, Abul K, Schlesinger, Larry S

“…Peroxisome proliferator-activated receptor (PPAR)γ is a global transcriptional regulator associated with anti-inflammatory actions. It is highly expressed in…”
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