Search Results - "SCHLESINGER, Larry S"

Innate Immune Gene Polymorphisms in Tuberculosis by AZAD, Abul K, SADEE, Wolfgang, SCHLESINGER, Larry S

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice by Oladunni, Fatai S., Park, Jun-Gyu, Pino, Paula A., Gonzalez, Olga, Akhter, Anwari, Allué-Guardia, Anna, Olmo-Fontánez, Angélica, Gautam, Shalini, Garcia-Vilanova, Andreu, Ye, Chengjin, Chiem, Kevin, Headley, Colwyn, Dwivedi, Varun, Parodi, Laura M., Alfson, Kendra J., Staples, Hilary M., Schami, Alyssa, Garcia, Juan I., Whigham, Alison, Platt, Roy Neal, Gazi, Michal, Martinez, Jesse, Chuba, Colin, Earley, Stephanie, Rodriguez, Oscar H., Mdaki, Stephanie Davis, Kavelish, Katrina N., Escalona, Renee, Hallam, Cory R. A., Christie, Corbett, Patterson, Jean L., Anderson, Tim J. C., Carrion, Ricardo, Dick, Edward J., Hall-Ursone, Shannan, Schlesinger, Larry S., Alvarez, Xavier, Kaushal, Deepak, Giavedoni, Luis D., Turner, Joanne, Martinez-Sobrido, Luis, Torrelles, Jordi B.

“…Vaccine and antiviral development against SARS-CoV-2 infection or COVID-19 disease would benefit from validated small animal models. Here, we show that…”
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Activation of transcription factor CREB in human macrophages by Mycobacterium tuberculosis promotes bacterial survival, reduces NF-kB nuclear transit and limits phagolysosome fusion by reduced necroptotic signaling by Leopold Wager, Chrissy M, Bonifacio, Jordan R, Simper, Jan, Naoun, Adrian A, Arnett, Eusondia, Schlesinger, Larry S

“…Macrophages are a first line of defense against pathogens. However, certain invading microbes modify macrophage responses to promote their own survival and…”
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Modeling the Mycobacterium tuberculosis Granuloma - the Critical Battlefield in Host Immunity and Disease by Guirado, Evelyn, Schlesinger, Larry S

“…Granulomas are the hallmark of Mycobacterium tuberculosis (M.tb) infection and thus sit at the center of tuberculosis (TB) immunopathogenesis. TB can result…”
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Impact of diabetes on the natural history of tuberculosis by Restrepo, Blanca I, Schlesinger, Larry S

“…Highlights • The current rise in diabetes mellitus (DM) worldwide has led to the re-emerging importance of DM to tuberculosis control. • We review the impact…”
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Modeling Granulomas in Response to Infection in the Lung by Hao, Wenrui, Schlesinger, Larry S, Friedman, Avner

“…Alveolar macrophages play a large role in the innate immune response of the lung. However, when these highly immune-regulatory cells are unable to eradicate…”
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Macrophage nuclear receptors: Emerging key players in infectious diseases by Leopold Wager, Chrissy M, Arnett, Eusondia, Schlesinger, Larry S

“…Nuclear receptors (NRs) are ligand-activated transcription factors that are expressed in a variety of cells, including macrophages. For decades, NRs have been…”
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Human Genetic Determinants of Viral Diseases by Kenney, Adam D, Dowdle, James A, Bozzacco, Leonia, McMichael, Temet M, St. Gelais, Corine, Panfil, Amanda R, Sun, Yan, Schlesinger, Larry S, Anderson, Matthew Z, Green, Patrick L, López, Carolina B, Rosenberg, Brad R, Wu, Li, Yount, Jacob S

“…Much progress has been made in the identification of specific human gene variants that contribute to enhanced susceptibility or resistance to viral diseases…”
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Current Sarcoidosis Models and the Importance of Focusing on the Granuloma by Locke, Landon W, Schlesinger, Larry S, Crouser, Elliott D

“…The inability to effectively model sarcoidosis in the laboratory or in animals continues to hinder the discovery and translation of new, targeted treatments…”
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Phagocytosis via complement or Fc-gamma receptors is compromised in monocytes from type 2 diabetes patients with chronic hyperglycemia by Restrepo, Blanca I, Twahirwa, Marcel, Rahbar, Mohammad H, Schlesinger, Larry S

“…Type 2 diabetes patients (DM2) have a higher risk of tuberculosis (TB) that may be attributed to functional defects in their mononuclear phagocytes given the…”
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Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b by Rajaram, Murugesan V. S., Ni, Bin, Morris, Jessica D., Brooks, Michelle N., Carlson, Tracy K., Bakthavachalu, Baskar, Schoenberg, Daniel R., Torrelles, Jordi B., Schlesinger, Larry S.

“…Contact of Mycobacterium tuberculosis (M.tb) with the immune system requires interactions between microbial surface molecules and host pattern recognition…”
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AmpliSeq transcriptome analysis of human alveolar and monocyte-derived macrophages over time in response to Mycobacterium tuberculosis infection by Papp, Audrey C, Azad, Abul K, Pietrzak, Maciej, Williams, Amanda, Handelman, Samuel K, Igo, Jr, Robert P, Stein, Catherine M, Hartmann, Katherine, Schlesinger, Larry S, Sadee, Wolfgang

“…Human alveolar macrophages (HAM) are primary bacterial niche and immune response cells during Mycobacterium tuberculosis (M.tb) infection, and human blood…”
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Myeloid cell interferon responses correlate with clearance of SARS-CoV-2 by Singh, Dhiraj K., Aladyeva, Ekaterina, Das, Shibali, Singh, Bindu, Esaulova, Ekaterina, Swain, Amanda, Ahmed, Mushtaq, Cole, Journey, Moodley, Chivonne, Mehra, Smriti, Schlesinger, Larry S., Artyomov, Maxim N., Khader, Shabaana A., Kaushal, Deepak

“…Emergence of mutant SARS-CoV-2 strains associated with an increased risk of COVID-19-related death necessitates better understanding of the early viral…”
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Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection by Sivangala Thandi, Ramya, Radhakrishnan, Rajesh Kumar, Tripathi, Deepak, Paidipally, Padmaja, Azad, Abul K, Schlesinger, Larry S, Samten, Buka, Mulik, Sachin, Vankayalapati, Ramakrishna

“…Macrophages are professional phagocytes known to play a vital role in controlling Mycobacterium tuberculosis (Mtb) infection and disease progression. Here we…”
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PPARγ is critical for Mycobacterium tuberculosis induction of Mcl-1 and limitation of human macrophage apoptosis by Arnett, Eusondia, Weaver, Ashlee M, Woodyard, Kiersten C, Montoya, Maria J, Li, Michael, Hoang, Ky V, Hayhurst, Andrew, Azad, Abul K, Schlesinger, Larry S

“…Peroxisome proliferator-activated receptor (PPAR)γ is a global transcriptional regulator associated with anti-inflammatory actions. It is highly expressed in…”
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Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization by Akhter, Anwari, Caution, Kyle, Abu Khweek, Arwa, Tazi, Mia, Abdulrahman, Basant A., Abdelaziz, Dalia H.A., Voss, Oliver H., Doseff, Andrea I., Hassan, Hoda, Azad, Abul K., Schlesinger, Larry S., Wewers, Mark D., Gavrilin, Mikhail A., Amer, Amal O.

“…Inflammasomes are multiprotein complexes that include members of the NLR (nucleotide-binding domain leucine-rich repeat containing) family and caspase-1. Once…”
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Modeling the immune rheostat of macrophages in the lung in response to infection by Day, Judy, Friedman, Avner, Schlesinger, Larry S

“…In the lung, alternatively activated macrophages (AAM) form the first line of defense against microbial infection. Due to the highly regulated nature of AAM,…”
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M. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcRγ-Chain, Grb2, and SHP-1 by Rajaram, Murugesan V.S., Arnett, Eusondia, Azad, Abul K., Guirado, Evelyn, Ni, Bin, Gerberick, Abigail D., He, Li-Zhen, Keler, Tibor, Thomas, Lawrence J., Lafuse, William P., Schlesinger, Larry S.

“…Despite its prominent role as a C-type lectin (CTL) pattern recognition receptor, mannose receptor (MR, CD206)-specific signaling molecules and pathways are…”
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Human isotype‐dependent inhibitory antibody responses against Mycobacterium tuberculosis by Zimmermann, Natalie, Thormann, Verena, Hu, Bo, Köhler, Anne‐Britta, Imai‐Matsushima, Aki, Locht, Camille, Arnett, Eusondia, Schlesinger, Larry S, Zoller, Thomas, Schürmann, Mariana, Kaufmann, Stefan HE, Wardemann, Hedda

“…Accumulating evidence from experimental animal models suggests that antibodies play a protective role against tuberculosis (TB). However, little is known about…”
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Zinc Modulates Endotoxin-Induced Human Macrophage Inflammation through ZIP8 Induction and C/EBPβ Inhibition by Pyle, Charlie J, Akhter, Saife, Bao, ShengYing, Dodd, Claire E, Schlesinger, Larry S, Knoell, Daren L

“…Two vital functions of the innate immune system are to initiate inflammation and redistribute micronutrients in favor of the host. Zinc is an essential…”
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