Search Results - "SCHLEIM, Klaus D"

Immune Enhancing Effect of a Growth Hormone Secretagogue by Koo, Gloria C, Huang, Christopher, Camacho, Ramon, Trainor, Charlotte, Blake, J. Tom, Sirotina-Meisher, Anna, Schleim, Klaus D, Wu, Tsuei-Ju, Cheng, Kang, Nargund, Ravi, McKissick, Gaylord

“…Growth hormone (GH) has been known to enhance immune responses, whether directly or through the insulin like growth factor-1, induced by GH. Recently a…”
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Ligand Activation Domain of Human Orphan Growth Hormone (GH) Secretagogue Receptor (GHS-R) Conserved from Pufferfish to Humans by Palyha, Oksana C, Feighner, Scott D, Tan, Carina P, McKee, Karen Kulju, Hreniuk, Donna L, Gao, Ying-Duo, Schleim, Klaus D, Yang, Lihu, Morriello, Gregori J, Nargund, Ravi, Patchett, Arthur A, Howard, Andrew D, Smith, Roy G

“…Synthetic ligands have been identified that reset and amplify the cycle of pulsatile GH secretion by interacting with the orphan GH-secretagogue receptor…”
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A Potent, Orally Bioavailable Benzazepinone Growth Hormone Secretagogue by DeVita, Robert J, Bochis, Richard, Frontier, Alison J, Kotliar, Andrew, Fisher, Michael H, Schoen, William R, Wyvratt, Matthew J, Cheng, Kang, Chan, Wanda W.-S, Butler, Bridget, Jacks, Thomas M, Hickey, Gerard J, Schleim, Klaus D, Leung, Kwan, Chen, Zhesheng, Chiu, S.-H. Lee, Feeney, William P, Cunningham, Paul K, Smith, Roy G

“…The identification of L-739,943 (8b), a potent, orally bioavailable benzolactam growth hormone secretagogue, is obtained from zwitterionic L-692,429 through…”
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Nipecotic and iso-nipecotic amides as potent and selective somatostatin subtype-2 receptor agonists by CHANGYOU ZHOU, LIANGQIN GUO, KANG CHENG, SCHAEFFER, James M, PATCHETT, Arthur A, LIHU YANG, MORRIELLO, Greg, PASTERNAK, Alex, PAN, Yanping, ROHRER, Susan P, BIRZIN, Elizebeth T, HUSKEY, Su-Er Wu, JACKS, Tom, SCHLEIM, Klaus D

“…N-Substituted nipecotic and iso-nipecotic amides of beta-methylTrpLys tert-butyl ester were found to be novel, selective and potent agonists of the…”
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Highly potent growth hormone secretagogues by Lu, Zhijian, Tata, James R., Cheng, Kang, Wei, Liente, Chan, Wanda W.-S., Butler, Bridget, Schleim, Klaus D., Jacks, Thomas M., Hickey, Gerard, Patchett, Arthur A.

“…During an effort to search for more potent growth hormone secretagogues, we discovered a class of compounds of which the best compound 8 was 7-fold more active…”
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1-[2(R)-(2-Amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl]-3- benzylpiperidine-3(S)-carboxylic Acid Ethyl Ester (L-163,540):  A Potent, Orally Bioavailable, and Short-Duration Growth Hormone Secretagogue by Yang, Lihu, Morriello, Greg, Patchett, Arthur A, Leung, Kwan, Jacks, Tom, Cheng, Kang, Schleim, Klaus D, Feeney, William, Chan, Wanda W.-S, Chiu, Shuet-Hing L, Smith, Roy G

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Potent 3-spiropiperidine growth hormone secretagogues by Yang, Lihu, Morriello, Greg, Prendergast, Kristine, Cheng, Kang, Jacks, Tom, Chan, Wanda W.-S, Schleim, Klaus D, Smith, Roy G, Patchett, Arthur A

“…Systematic SAR studies of the different regioisomers and homologues of the spiro(indane-1,4′-piperidine) moiety in the growth hormone secretagogue L-162,752…”
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Substituted bridged phenyl piperidines: orally active growth hormone secretagogues by Lu, Zhijian, Tata, James R., Cheng, Kang, Wei, Liente, Chan, Wanda W.-S., Butler, Bridget, Schleim, Klaus D., Jacks, Thomas M., Hickey, Gerard, Patchett, Arthur A.

“…A new series of growth hormone secretagogues have been discovered. The best compound, 26j, shows excellent ability to release growth hormone both in vitro and…”
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Potent, orally bioavailable somatostatin agonists: Good absorption achieved by urea backbone cyclization by Pasternak, Alexander, Pan, Yanping, Marino, Dominick, Sanderson, Philip E., Mosley, Ralph, Rohrer, Susan P., Birzin, Elizabeth T., Huskey, Su-Er Wu, Jacks, Tom, Schleim, Klaus D, Cheng, Kang, Schaeffer, James M., Patchett, Arthur A., Yang, Lihu

“…Backbone cyclization of urea-based somatostatin agonists resulted in novel, orally bioavailable agonists. Binding assays confirmed that the resulting…”
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Synthesis and biological activities of phenyl piperazine- based peptidomimetic growth hormone secretagogues by BARAKAT, K. J, KANG CHENG, NARGUND, R. P, CHAN, W. W.-S, BUTLER, B. S, JACKS, T. M, SCHLEIM, K. D, HORA, D. F, HICKEY, G. J, SMITH, R. G, PATCHETT, A. A

“…A new class of potent, orally active phenyl piperazine-based GH secretagogues have been discovered from attempts to mimic the arrangement of the phenyl…”
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Quaternary heterocyclylamino beta-lactams. V. L-640,876 treatment of induced enterotoxigenic colibacillosis (scours) in calves and piglets by Jacks, T M, Schleim, K D, Miller, B M, Shungu, D L, Weinberg, E, Gadebusch, H H

“…A new semisynthetic cephalosporin antibiotic designated L-640,876, 7-beta-(1-benzylpyridinium-4-yl)amino-3-[( (1-methyl-1H-tetrazol-5-yl)thio]…”
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Thiazole-derived potent, highly bioavailable short duration growth hormone secretagogues by Lihu Yang, Morriello, Greg, Kwan Leung, Jacks, Tom, Kang Cheng, Schleim, Klaus D., Smith, Roy, Patchett, Arthur A.

“…Replacement of the phenyl in 3 with a 2-pyridyl or 4-thiazolyl group resulted in increased potency in the rat pituitary cell GH release assay and in beagles…”
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The design and synthesis of orally active short duration spiroindane growth hormone secretagogues by Tata, James R., Lu, Zhijian, Jacks, Thomas M., Schleim, Klaus D., Cheng, Kang, Wei, Liente, Chan, Wanda W.-S., Butler, Bridget, Tsou, Nancy, Leung, Kwan, Chiu, S.-H.L., Hickey, Gerard, Smith, Roy G., Patchett, Arthur A.

“…The design, synthesis, and activities of a series of short duration spiroindane growth hormone secretagogues are reported. Incorporation of a readily…”
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