Search Results - "SCHLEIM, K. D"

Immune Enhancing Effect of a Growth Hormone Secretagogue by Koo, Gloria C, Huang, Christopher, Camacho, Ramon, Trainor, Charlotte, Blake, J. Tom, Sirotina-Meisher, Anna, Schleim, Klaus D, Wu, Tsuei-Ju, Cheng, Kang, Nargund, Ravi, McKissick, Gaylord

“…Growth hormone (GH) has been known to enhance immune responses, whether directly or through the insulin like growth factor-1, induced by GH. Recently a…”
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Repeat administration of the GH secretagogue MK-0677 increases and maintains elevated IGF-I levels in beagles by Hickey, G J, Jacks, T M, Schleim, K D, Frazier, E, Chen, H Y, Krupa, D, Feeney, W, Nargund, R P, Patchett, A A, Smith, R G

“…We have reported that MK-0677 is a novel, orally active GH secretagogue that stimulates an immediate and long-lasting increase in serum GH levels in dogs…”
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Increases in Circulating Insulin-Like Growth Factor I Levels by the Oral Growth Hormone Secretagogue MK-0677 in the Beagle Are Dependent upon Pituitary Mediation by Schleim, K.-D., Jacks, T., Cunningham, P., Feeney, W., Frazier, E. G., Niebauer, G. W., Zhang, D., Chen, H., Smith, R. G., Hickey, G.

“…Abstract It has been well established that the spiroindoline sulfonamide MK-0677 stimulates GH secretion from the pituitary both in vitro and in vivo. MK-0677…”
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Potent 3-spiropiperidine growth hormone secretagogues by Yang, Lihu, Morriello, Greg, Prendergast, Kristine, Cheng, Kang, Jacks, Tom, Chan, Wanda W.-S, Schleim, Klaus D, Smith, Roy G, Patchett, Arthur A

“…Systematic SAR studies of the different regioisomers and homologues of the spiro(indane-1,4′-piperidine) moiety in the growth hormone secretagogue L-162,752…”
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Potent, orally bioavailable somatostatin agonists: Good absorption achieved by urea backbone cyclization by Pasternak, Alexander, Pan, Yanping, Marino, Dominick, Sanderson, Philip E., Mosley, Ralph, Rohrer, Susan P., Birzin, Elizabeth T., Huskey, Su-Er Wu, Jacks, Tom, Schleim, Klaus D, Cheng, Kang, Schaeffer, James M., Patchett, Arthur A., Yang, Lihu

“…Backbone cyclization of urea-based somatostatin agonists resulted in novel, orally bioavailable agonists. Binding assays confirmed that the resulting…”
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Thiazole-derived potent, highly bioavailable short duration growth hormone secretagogues by Lihu Yang, Morriello, Greg, Kwan Leung, Jacks, Tom, Kang Cheng, Schleim, Klaus D., Smith, Roy, Patchett, Arthur A.

“…Replacement of the phenyl in 3 with a 2-pyridyl or 4-thiazolyl group resulted in increased potency in the rat pituitary cell GH release assay and in beagles…”
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Synthesis and biological activities of phenyl piperazine- based peptidomimetic growth hormone secretagogues by BARAKAT, K. J, KANG CHENG, NARGUND, R. P, CHAN, W. W.-S, BUTLER, B. S, JACKS, T. M, SCHLEIM, K. D, HORA, D. F, HICKEY, G. J, SMITH, R. G, PATCHETT, A. A

“…A new class of potent, orally active phenyl piperazine-based GH secretagogues have been discovered from attempts to mimic the arrangement of the phenyl…”
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Ligand activation domain of human orphan growth hormone (GH) secretagogue receptor (GHS-R) conserved from Pufferfish to humans by Palyha, O C, Feighner, S D, Tan, C P, McKee, K K, Hreniuk, D L, Gao, Y D, Schleim, K D, Yang, L, Morriello, G J, Nargund, R, Patchett, A A, Howard, A D, Smith, R G

“…Synthetic ligands have been identified that reset and amplify the cycle of pulsatile GH secretion by interacting with the orphan GH-secretagogue receptor…”
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Increases in circulating insulin-like growth factor I levels by the oral growth hormone secretagogue MK-0677 in the beagle are dependent upon pituitary mediation by Schleim, K D, Jacks, T, Cunningham, P, Feeney, W, Frazier, E G, Niebauer, G W, Zhang, D, Chen, H, Smith, R G, Hickey, G

“…It has been well established that the spiroindoline sulfonamide MK-0677 stimulates GH secretion from the pituitary both in vitro and in vivo. MK-0677 has also…”
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Increases in Circulating Insulin-Like Growth Factor I Levels by the Oral Growth Hormone Secretagogue MK-0677 in the Beagle Are Dependent upon Pituitary Mediation1 by Schleim, K.-D, Jacks, T, Cunningham, P, Feeney, W, Frazier, E. G, Niebauer, G. W, Zhang, D, Chen, H, Smith, R. G, Hickey, G

“…It has been well established that the spiroindoline sulfonamide MK-0677 stimulates GH secretion from the pituitary both in vitro and in vivo. MK-0677 has also…”
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Nipecotic and iso-nipecotic amides as potent and selective somatostatin subtype-2 receptor agonists by CHANGYOU ZHOU, LIANGQIN GUO, KANG CHENG, SCHAEFFER, James M, PATCHETT, Arthur A, LIHU YANG, MORRIELLO, Greg, PASTERNAK, Alex, PAN, Yanping, ROHRER, Susan P, BIRZIN, Elizebeth T, HUSKEY, Su-Er Wu, JACKS, Tom, SCHLEIM, Klaus D

“…N-Substituted nipecotic and iso-nipecotic amides of beta-methylTrpLys tert-butyl ester were found to be novel, selective and potent agonists of the…”
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1-[2(R)-(2-Amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl]-3- benzylpiperidine-3(S)-carboxylic Acid Ethyl Ester (L-163,540):  A Potent, Orally Bioavailable, and Short-Duration Growth Hormone Secretagogue by Yang, Lihu, Morriello, Greg, Patchett, Arthur A, Leung, Kwan, Jacks, Tom, Cheng, Kang, Schleim, Klaus D, Feeney, William, Chan, Wanda W.-S, Chiu, Shuet-Hing L, Smith, Roy G

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The design and synthesis of orally active short duration spiroindane growth hormone secretagogues by Tata, James R., Lu, Zhijian, Jacks, Thomas M., Schleim, Klaus D., Cheng, Kang, Wei, Liente, Chan, Wanda W.-S., Butler, Bridget, Tsou, Nancy, Leung, Kwan, Chiu, S.-H.L., Hickey, Gerard, Smith, Roy G., Patchett, Arthur A.

“…The design, synthesis, and activities of a series of short duration spiroindane growth hormone secretagogues are reported. Incorporation of a readily…”
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Benzylated 1,2,3-triazoles as anticoccidiostats by Bochis, Richard J, Chabala, John C, Harris, Ellwood, Peterson, Louis H, Barash, Louis, Beattie, Thomas, Brown, Jeannette E, Graham, Donald W, Waksmunski, Frank S

“…Substituted 5-amino-4-carbamoyl-1,2,3-triazoles 3a-w were prepared by two synthetic schemes and evaluated in vivo for anticoccidial activity. Both schemes…”
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Cephamycin C Treatment of Induced Enterotoxigenic Colibacillosis (Scours) in Calves and Piglets by Jacks, T M, Schleim, K D, Judith, F R, Miller, B M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Anticoccidial and tolerance studies in the chicken with two 6-amino-9-(substituted benzyl)purines by Miller, B M, McManus, E C, Olson, G, Schleim, K D, Van Iderstine, A A, Graham, D W, Brown, J E, Rogers, E F

“…Initial assays of 6-amino-9-(2-chloro-6-fluorobenzyl) purine (MK-302) and 6-amino-9-(2,6-dichlorobenzyl)purine (coded L-628,914) showed potential as…”
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Eimeria tenella: specific reversal of t-butylaminoethanol toxicity for parasite and host by choline and dimethylaminoethanol by McManus, E C, Rogers, E F, Miller, B M, Judith, F R, Schleim, K D, Olson, G

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A Potent, Orally Bioavailable Benzazepinone Growth Hormone Secretagogue by DeVita, Robert J, Bochis, Richard, Frontier, Alison J, Kotliar, Andrew, Fisher, Michael H, Schoen, William R, Wyvratt, Matthew J, Cheng, Kang, Chan, Wanda W.-S, Butler, Bridget, Jacks, Thomas M, Hickey, Gerard J, Schleim, Klaus D, Leung, Kwan, Chen, Zhesheng, Chiu, S.-H. Lee, Feeney, William P, Cunningham, Paul K, Smith, Roy G

“…The identification of L-739,943 (8b), a potent, orally bioavailable benzolactam growth hormone secretagogue, is obtained from zwitterionic L-692,429 through…”
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Increases in Circulating Insulin-Like Growth Factor I Levels by the Oral Growth Hormone Secretagogue MK-0677 in the Beagle Are Dependent upon Pituitary Mediation 1 by Schleim, K.-D., Jacks, T., Cunningham, P., Feeney, W., Frazier, E. G., Niebauer, G. W., Zhang, D., Chen, H., Smith, R. G., Hickey, G.

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Substituted bridged phenyl piperidines: orally active growth hormone secretagogues by Lu, Zhijian, Tata, James R., Cheng, Kang, Wei, Liente, Chan, Wanda W.-S., Butler, Bridget, Schleim, Klaus D., Jacks, Thomas M., Hickey, Gerard, Patchett, Arthur A.

“…A new series of growth hormone secretagogues have been discovered. The best compound, 26j, shows excellent ability to release growth hormone both in vitro and…”
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