Search Results - "SCHLEE, Martin"

Discriminating self from non-self in nucleic acid sensing by Schlee, Martin, Hartmann, Gunther

“…Key Points Immune sensing of foreign nucleic acids among abundant self nucleic acids is a hallmark of virus detection and antiviral defence. Efficient…”
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Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2 by Ostendorf, Thomas, Zillinger, Thomas, Andryka, Katarzyna, Schlee-Guimaraes, Thais Marina, Schmitz, Saskia, Marx, Samira, Bayrak, Kübra, Linke, Rebecca, Salgert, Sarah, Wegner, Julia, Grasser, Tatjana, Bauersachs, Sonja, Soltesz, Leon, Hübner, Marc P., Nastaly, Maximilian, Coch, Christoph, Kettwig, Matthias, Roehl, Ingo, Henneke, Marco, Hoerauf, Achim, Barchet, Winfried, Gärtner, Jutta, Schlee, Martin, Hartmann, Gunther, Bartok, Eva

“…Human toll-like receptor 8 (TLR8) activation induces a potent T helper-1 (Th1) cell response critical for defense against intracellular pathogens, including…”
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The Chase for the RIG-I Ligand—Recent Advances by Schlee, Martin, Hartmann, Gunther

“…Multicellular organisms evolved efficient host-defense mechanisms to sense viruses and to block their replication and spread. Invertebrates and plants mainly…”
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Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA by Herzner, Anna-Maria, Hagmann, Cristina Amparo, Goldeck, Marion, Wolter, Steven, Kübler, Kirsten, Wittmann, Sabine, Gramberg, Thomas, Andreeva, Liudmila, Hopfner, Karl-Peter, Mertens, Christina, Zillinger, Thomas, Jin, Tengchuan, Xiao, Tsan Sam, Bartok, Eva, Coch, Christoph, Ackermann, Damian, Hornung, Veit, Ludwig, Janos, Barchet, Winfried, Hartmann, Gunther, Schlee, Martin

“…Truncated reverse transcription of HIV RNA produces a single-stranded DNA intermediate with a unique Y-DNA stem-loop structure flanked by unpaired guanines…”
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5'-Triphosphate RNA Is the Ligand for RIG-I by Hornung, Veit, Ellegast, Jana, Kim, Sarah, Brzózka, Krzysztof, Jung, Andreas, Kato, Hiroki, Poeck, Hendrik, Akira, Shizuo, Conzelmann, Karl-Klaus, Schlee, Martin, Endres, Stefan, Hartmann, Gunther

“…The structural basis for the distinction of viral RNA from abundant self RNA in the cytoplasm of virally infected cells is largely unknown. We demonstrated…”
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Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency by Wegner, Julia, Hunkler, Charlotte, Ciupka, Katrin, Hartmann, Gunther, Schlee, Martin

“…TBK1 and IKKϵ are related, crucial kinases in antiviral immune signaling pathways downstream of cytosolic nucleic acid receptors such as cGAS and RIG-I-like…”
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An epigenetic GPI anchor defect impairs TLR4 signaling in the B cell transdifferentiation model for primary human monocytes BLaER1 by Wegner, Julia, Zillinger, Thomas, Schlee-Guimaraes, Thais Marina, Bartok, Eva, Schlee, Martin

“…Antigen-presenting myeloid cells like monocytes detect invading pathogens via pattern recognition receptors (PRRs) and initiate adaptive and innate immune…”
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Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus by Schlee, Martin, Roth, Andreas, Hornung, Veit, Hagmann, Cristina Amparo, Wimmenauer, Vera, Barchet, Winfried, Coch, Christoph, Janke, Markus, Mihailovic, Aleksandra, Wardle, Greg, Juranek, Stefan, Kato, Hiroki, Kawai, Taro, Poeck, Hendrik, Fitzgerald, Katherine A., Takeuchi, Osamu, Akira, Shizuo, Tuschl, Thomas, Latz, Eicke, Ludwig, Janos, Hartmann, Gunther

“…Antiviral immunity is triggered by immunorecognition of viral nucleic acids. The cytosolic helicase RIG-I is a key sensor of viral infections and is activated…”
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Accessing the therapeutic potential of immunostimulatory nucleic acids by Barchet, Winfried, Wimmenauer, Vera, Schlee, Martin, Hartmann, Gunther

“…Short synthetic CpG oligodesoxynucleotides (CpG ODN) that activate plasmacytoid dendritic cells (PDC) and B-cells via the endosomal Toll-like receptor (TLR) 9…”
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Author Correction: An epigenetic GPI anchor defect impairs TLR4 signaling in the B cell transdifferentiation model for primary human monocytes BLaER1 by Wegner, Julia, Zillinger, Thomas, Schlee-Guimaraes, Thais Marina, Bartok, Eva, Schlee, Martin

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Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication by Tsukamoto, Yuta, Hiono, Takahiro, Yamada, Shintaro, Matsuno, Keita, Faist, Aileen, Claff, Tobias, Hou, Jianyu, Namasivayam, Vigneshwaran, Vom Hemdt, Anja, Sugimoto, Satoko, Ng, Jin Ying, Christensen, Maria H, Tesfamariam, Yonas M, Wolter, Steven, Juranek, Stefan, Zillinger, Thomas, Bauer, Stefan, Hirokawa, Takatsugu, Schmidt, Florian I, Kochs, Georg, Shimojima, Masayuki, Huang, Yi-Shuian, Pichlmair, Andreas, Kümmerer, Beate M, Sakoda, Yoshihiro, Schlee, Martin, Brunotte, Linda, Müller, Christa E, Igarashi, Manabu, Kato, Hiroki

“…Orthomyxo- and bunyaviruses steal the 5' cap portion of host RNAs to prime their own transcription in a process called "cap snatching." We report that RNA…”
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MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I by Brägelmann, Johannes, Lorenz, Carina, Borchmann, Sven, Nishii, Kazuya, Wegner, Julia, Meder, Lydia, Ostendorp, Jenny, Ast, David F., Heimsoeth, Alena, Nakasuka, Takamasa, Hirabae, Atsuko, Okawa, Sachi, Dammert, Marcel A., Plenker, Dennis, Klein, Sebastian, Lohneis, Philipp, Gu, Jianing, Godfrey, Laura K., Forster, Jan, Trajkovic-Arsic, Marija, Zillinger, Thomas, Haarmann, Mareike, Quaas, Alexander, Lennartz, Stefanie, Schmiel, Marcel, D’Rozario, Joshua, Thomas, Emily S., Li, Henry, Schmitt, Clemens A., George, Julie, Thomas, Roman K., von Karstedt, Silvia, Hartmann, Gunther, Büttner, Reinhard, Ullrich, Roland T., Siveke, Jens T., Ohashi, Kadoaki, Schlee, Martin, Sos, Martin L.

“…Kinase inhibitors suppress the growth of oncogene driven cancer but also enforce the selection of treatment resistant cells that are thought to promote tumor…”
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Chronic endoplasmic reticulum stress in myotonic dystrophy type 2 promotes autoimmunity via mitochondrial DNA release by Rösing, Sarah, Ullrich, Fabian, Meisterfeld, Susann, Schmidt, Franziska, Mlitzko, Laura, Croon, Marijana, Nattrass, Ryan G, Eberl, Nadia, Mahlberg, Julia, Schlee, Martin, Wieland, Anja, Simon, Philipp, Hilbig, Daniel, Reuner, Ulrike, Rapp, Alexander, Bremser, Julia, Mirtschink, Peter, Drukewitz, Stephan, Zillinger, Thomas, Beissert, Stefan, Paeschke, Katrin, Hartmann, Gunther, Trifunovic, Aleksandra, Bartok, Eva, Günther, Claudia

“…Myotonic dystrophy type 2 (DM2) is a tetranucleotide CCTG repeat expansion disease associated with an increased prevalence of autoimmunity. Here, we identified…”
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Influenza A Infection Stimulates RIG-I and Enhances Effector Function of Primary Human NK Cells by Mohamed, Adham Abuelola, Soler, Sofía, Wegner, Julia, Bartok, Eva, Stankovic, Sanda, Brooks, Andrew G, Schlee, Martin

“…Immune surveillance by natural killer (NK) cells and their recruitment to sites of inflammation renders them susceptible to viral infection, potentially…”
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RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection by Marx, Samira, Kümmerer, Beate M., Grützner, Christian, Kato, Hiroki, Schlee, Martin, Renn, Marcel, Bartok, Eva, Hartmann, Gunther

“…The SARS-CoV-2 pandemic has underscored the need for rapidly usable prophylactic and antiviral treatments against emerging viruses. The targeted stimulation of…”
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RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells by Hagmann, Cristina Amparo, Herzner, Anna Maria, Abdullah, Zeinab, Zillinger, Thomas, Jakobs, Christopher, Schuberth, Christine, Coch, Christoph, Higgins, Paul G, Wisplinghoff, Hilmar, Barchet, Winfried, Hornung, Veit, Hartmann, Gunther, Schlee, Martin

“…The innate immune system senses pathogens by pattern recognition receptors in different cell compartments. In the endosome, bacteria are generally recognized…”
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The many faces of cGAS: how cGAS activation is controlled in the cytosol, the nucleus, and during mitosis by Herzner, Anna-Maria, Schlee, Martin, Bartok, Eva

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Human TLR8 Senses RNA From Plasmodium falciparum -Infected Red Blood Cells Which Is Uniquely Required for the IFN-γ Response in NK Cells by Coch, Christoph, Hommertgen, Benjamin, Zillinger, Thomas, Daßler-Plenker, Juliane, Putschli, Bastian, Nastaly, Maximilian, Kümmerer, Beate M, Scheunemann, Johanna F, Schumak, Beatrix, Specht, Sabine, Schlee, Martin, Barchet, Winfried, Hoerauf, Achim, Bartok, Eva, Hartmann, Gunther

“…During blood-stage malaria, the innate immune system initiates the production of pro-inflammatory cytokines, including IFN-γ, that are critical to host defense…”
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Approaching the RNA ligand for RIG-I? by Schlee, Martin, Hartmann, Evelyn, Coch, Christoph, Wimmenauer, Vera, Janke, Markus, Barchet, Winfried, Hartmann, Gunther

“…Innate and antigen-specific antiviral immunity are triggered by immunorecognition of viral nucleic acids. The helicase retinoic acid-inducible gene I (RIG-I)…”
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Targeting the Cytosolic Innate Immune Receptors RIG‐I and MDA5 Effectively Counteracts Cancer Cell Heterogeneity in Glioblastoma by Glas, Martin, Coch, Christoph, Trageser, Daniel, Daßler, Juliane, Simon, Matthias, Koch, Philipp, Mertens, Jerome, Quandel, Tamara, Gorris, Raphaela, Reinartz, Roman, Wieland, Anja, Von Lehe, Marec, Pusch, Annette, Roy, Kristin, Schlee, Martin, Neumann, Harald, Fimmers, Rolf, Herrlinger, Ulrich, Brüstle, Oliver, Hartmann, Gunther, Besch, Robert, Scheffler, Björn

“…Cellular heterogeneity, for example, the intratumoral coexistence of cancer cells with and without stem cell characteristics, represents a potential root of…”
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