Search Results - "SCHIOPU, Elena"

The sphingosine-1-phosphate receptor: A novel therapeutic target for multiple sclerosis and other autoimmune diseases by Mao-Draayer, Yang, Sarazin, Jeffrey, Fox, David, Schiopu, Elena

“…Abstract Multiple sclerosis (MS) is a prototype autoimmune disease of the central nervous system (CNS). Currently, there is no drug that provides a cure for…”
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Immune Checkpoint Inhibitors and Risk of Type 1 Diabetes by Chen, Xuan, Affinati, Alison H, Lee, Yungchun, Turcu, Adina F, Henry, Norah Lynn, Schiopu, Elena, Qin, Angel, Othus, Megan, Clauw, Dan, Ramnath, Nithya, Zhao, Lili

“…Type 1 diabetes mellitus (T1DM) is a rare, irreversible immune-related adverse event reported in patients receiving treatment with immune checkpoint inhibitors…”
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Abatacept in Early Diffuse Cutaneous Systemic Sclerosis: Results of a Phase II Investigator‐Initiated, Multicenter, Double‐Blind, Randomized, Placebo‐Controlled Trial by Khanna, Dinesh, Spino, Cathie, Johnson, Sindhu, Chung, Lorinda, Whitfield, Michael L., Denton, Christopher P., Berrocal, Veronica, Franks, Jennifer, Mehta, Bhavan, Molitor, Jerry, Steen, Virginia D., Lafyatis, Robert, Simms, Robert W., Gill, Anna, Kafaja, Suzanne, Frech, Tracy M., Hsu, Vivien, Domsic, Robyn T., Pope, Janet E., Gordon, Jessica K., Mayes, Maureen D., Schiopu, Elena, Young, Amber, Sandorfi, Nora, Park, Jane, Hant, Faye N., Bernstein, Elana J., Chatterjee, Soumya, Castelino, Flavia V., Ajam, Ali, Wang, Yue, Wood, Tammara, Allanore, Yannick, Matucci‐Cerinic, Marco, Distler, Oliver, Singer, Ora, Bush, Erica, Fox, David A., Furst, Daniel E.

“…Objective T cells play a key role in the pathogenesis of early systemic sclerosis. This study was undertaken to assess the safety and efficacy of abatacept in…”
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Photoacoustic tomography for human musculoskeletal imaging and inflammatory arthritis detection by Jo, Janggun, Tian, Chao, Xu, Guan, Sarazin, Jeffrey, Schiopu, Elena, Gandikota, Girish, Wang, Xueding

“…With the capability of assessing high resolution optical contrast in soft tissues, photoacoustic imaging (PAI) can offer valuable structural and functional…”
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Long-Term Outcomes in Systemic Sclerosis-Associated Pulmonary Arterial Hypertension From the Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma Registry (PHAROS) by Kolstad, Kathleen D., Li, Shufeng, Steen, Virginia, Chung, Lorinda, Bolster, Marcy B., Csuka, Mary Ellen, Derk, Chris T., Domsic, Robyn T., Fischer, Aryeh, Frech, Tracy, Furie, Richard, Furst, Daniel, Goldberg, Avram Z., Gomberg-Maitland, Mardi, Gordon, Jessica, Hant, Faye, Hill, Nicholas, Hinchcliff, Monique, Horn, Evelyn, Hummers, Laura, Hsu, Vivien, Kafaja, Susanna, Kassab, Firas, Khanna, Dinesh, Medsger, Thomas A., Preston, Ioana, Molitor, Jerry, Saketkoo, Lesley, Shapiro, Lee, Schiopu, Elena, Silver, Rick, Simms, Robert, Varga, John, Wigley, Frederick

“…Pulmonary arterial hypertension (PAH) is a leading cause of death in patients with systemic sclerosis (SSc). The purpose of this study was to assess long-term…”
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Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic Factors by Tsou, Pei‐Suen, Wren, Jonathan D., Amin, M. Asif, Schiopu, Elena, Fox, David A., Khanna, Dinesh, Sawalha, Amr H.

“…Objective Vascular dysfunction represents a disease‐initiating event in systemic sclerosis (SSc; scleroderma). Results of recent studies suggest that…”
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The American College of Rheumatology Provisional Composite Response Index for Clinical Trials in Early Diffuse Cutaneous Systemic Sclerosis by Khanna, Dinesh, Berrocal, Veronica J., Giannini, Edward H., Seibold, James R., Merkel, Peter A., Mayes, Maureen D., Baron, Murray, Clements, Philip J., Steen, Virginia, Assassi, Shervin, Schiopu, Elena, Phillips, Kristine, Simms, Robert W., Allanore, Yannick, Denton, Christopher P., Distler, Oliver, Johnson, Sindhu R., Matucci‐Cerinic, Marco, Pope, Janet E., Proudman, Susanna M., Siegel, Jeffrey, Wong, Weng Kee, Wells, Athol U., Furst, Daniel E.

“…Objective Early diffuse cutaneous systemic sclerosis (dcSSc) is characterized by rapid changes in the skin and internal organs. The objective of this study was…”
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Photoacoustic Imaging of COVID-19 Vaccine Site Inflammation of Autoimmune Disease Patients by Jo, Janggun, Mills, David, Dentinger, Aaron, Chamberland, David, Abdulaziz, Nada M, Wang, Xueding, Schiopu, Elena, Gandikota, Girish

“…Based on the observations made in rheumatology clinics, autoimmune disease (AD) patients on immunosuppressive (IS) medications have variable vaccine site…”
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Novel lung imaging biomarkers and skin gene expression subsetting in dasatinib treatment of systemic sclerosis-associated interstitial lung disease by Martyanov, Viktor, Kim, Grace-Hyun J, Hayes, Wendy, Du, Shuyan, Ganguly, Bishu J, Sy, Oumar, Lee, Sun Ku, Bogatkevich, Galina S, Schieven, Gary L, Schiopu, Elena, Marangoni, Roberta Gonçalves, Goldin, Jonathan, Whitfield, Michael L, Varga, John

“…There are no effective treatments or validated clinical response markers in systemic sclerosis (SSc). We assessed imaging biomarkers and performed gene…”
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Safety and tolerability of intravenous immunoglobulin in patients with active dermatomyositis: results from the randomised, placebo-controlled ProDERM study by Aggarwal, Rohit, Schessl, Joachim, Charles-Schoeman, Christina, Bata-Csörgő, Zsuzsanna, Dimachkie, Mazen M, Griger, Zoltan, Moiseev, Sergey, Oddis, Chester V, Schiopu, Elena, Vencovský, Jiri, Beckmann, Irene, Clodi, Elisabeth, Levine, Todd

“…Dermatomyositis is an idiopathic inflammatory myopathy characterised by rashes and progressive muscle weakness. The recent ProDERM (Progress in…”
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Survival and Predictors of Mortality in Systemic Sclerosis‐Associated Pulmonary Arterial Hypertension: Outcomes From the Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma Registry by Chung, Lorinda, Domsic, Robyn T., Lingala, Bharathi, Alkassab, Firas, Bolster, Marcy, Csuka, M. E., Derk, Chris, Fischer, Aryeh, Frech, Tracy, Furst, Daniel E., Gomberg‐Maitland, Mardi, Hinchcliff, Monique, Hsu, Vivien, Hummers, Laura K., Khanna, Dinesh, Medsger, Thomas A., Molitor, Jerry A., Preston, Ioana R., Schiopu, Elena, Shapiro, Lee, Silver, Richard, Simms, Robert, Varga, John, Gordon, Jessica K., Steen, Virginia D.

“…Objective To assess cumulative survival rates and identify independent predictors of mortality in patients with incident systemic sclerosis (SSc)–associated…”
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Survival in Systemic Sclerosis With Pulmonary Arterial Hypertension Has Not Improved in the Modern Era by Rubenfire, Melvyn, MD, Huffman, Mark D., MD, MPH, Krishnan, Sangeetha, MS, Seibold, James R., MD, Schiopu, Elena, MD, McLaughlin, Vallerie V., MD, FCCP

“…Background The impact of modern therapy on survival in pulmonary arterial hypertension (PAH) associated with systemic sclerosis (SSc) is not clear. We sought…”
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Ipilimumab induced digital vasculitis by Padda, Amrita, Schiopu, Elena, Sovich, Justin, Ma, Vincent, Alva, Ajjai, Fecher, Leslie

“…Immune check point inhibitors (ICIs) have emerged as a new therapeutic paradigm for a variety of malignancies including metastatic melanoma. As the use of ICIs…”
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Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma (PHAROS): Baseline Characteristics and Description of Study Population by HINCHCLIFF, Monique, FISCHER, Aryeh, SCHIOPU, Elena, STEEN, Virginia D

“…Pulmonary arterial hypertension (PAH) increases mortality in systemic sclerosis (SSc). The multicenter PHAROS registry (Pulmonary Hypertension Assessment and…”
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Utility of Coronary Calcium Scoring (CCS) in Connective Tissue Disorders (CTDs) for the Evaluation of Subclinical Coronary Atherosclerosis – A Systematic Review by Farshad, Sohail, Halalau, Alexandra, Townsend, Whitney, Schiopu, Elena

“…Objective To assess the current state of knowledge for the utility of coronary calcium scoring (CCS) in connective tissue disorders (CTDs) as it relates to the…”
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Prevalence, Correlates and Outcomes of Gastric Antral Vascular Ectasia in Systemic Sclerosis: A EUSTAR Case-control Study by GHRENASSIA, Etienne, AVOUAC, Jérome, BEREZNE, Alice, CABANE, Jean, INGEGNOLI, Francesca, ROSATO, Edoardo, CARAMASCHI, Paola, HESSELSTRAND, Roger, WALKER, Ulrich A, ALEGRE-SANCHO, Juan Jose, ZARROUK, Virginie, AGARD, Christian, KHANNA, Dinesh, RICCIERI, Valeria, SCHIOPU, Elena, GLADUE, Heather, STEEN, Virginia D, ALLANORE, Yannick, DERK, Chris T, DISTLER, Oliver, YOSSRA ATEF SULIMAN, AIRO, Paolo, CARREIRA, Patricia E, FOTI, Rosario, GRANEL, Brigitte

“…To estimate the prevalence, determine the subgroups at risk, and the outcomes of patients with systemic sclerosis (SSc) and gastric antral vascular ectasia…”
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Activation of the Thromboxane A2 Receptor by 8-Isoprostane Inhibits the Pro-Angiogenic Effect of Vascular Endothelial Growth Factor in Scleroderma by Tsou, Pei-Suen, Amin, M. Asif, Campbell, Phillip L., Zakhem, George, Balogh, Beatrix, Edhayan, Gautam, Ohara, Ray A., Schiopu, Elena, Khanna, Dinesh, Koch, Alisa E., Fox, David A.

“…The pathogenesis of scleroderma (SSc) includes components of autoimmunity, vascular dysfunction, and accumulation of extracellular matrix. 8-isoprostane, an…”
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Sustained and improved guselkumab response in patients with active psoriatic arthritis regardless of baseline demographic and disease characteristics: pooled results through week 52 of two phase III, randomised, placebo-controlled studies by Ritchlin, Christopher T, Mease, Philip J, Boehncke, Wolf-Henning, Tesser, John, Schiopu, Elena, Chakravarty, Soumya D, Kollmeier, Alexa P, Xu, Xie L, Shawi, May, Jiang, Yusang, Sheng, Shihong, Wang, Yanli, Xu, Stephen, Merola, Joseph F, McInnes, Iain B, Deodhar, Atul

“…ObjectivesTo evaluate the efficacy through 52 weeks of guselkumab, an interleukin 23-p19 subunit inhibitor, in subgroups of pooled psoriatic arthritis (PsA)…”
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Development of pulmonary hypertension in a high-risk population with systemic sclerosis in the Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma (PHAROS) cohort study by Hsu, Vivien M., MD, Chung, Lorinda, MD, MS, Hummers, Laura K., MD, Wigley, Fredrick, MD, Simms, Robert, MD, Bolster, Marcy, MD, Silver, Rick, MD, Fischer, Aryeh, MD, Hinchcliff, Monique E., MD, MS, Varga, John, MD, Goldberg, Avram Z., MD, Derk, Chris T., MD, Schiopu, Elena, MD, Khanna, Dinesh, MD, Shapiro, Lee S., MD, Domsic, Robyn T., MD, Medsger, Thomas, MD, Mayes, Maureen D., MD, MPH, Furst, Daniel, MD, Csuka, Mary E., MD, Molitor, Jerry A., MD, Alkassab, Firas, MD, Steen, Virginia D., MD

“…Abstract Objectives PHAROS registry is a prospective longitudinal cohort study to understand the natural history of pulmonary hypertension (PH) in systemic…”
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Relapsing Polychondritis following Treatment with Secukinumab for Ankylosing Spondylitis: Case Report and Review of the Literature by Zheutlin, Alexander, Schiopu, Elena

“…Relapsing polychondritis (RP) is an autoimmune disorder that often occurs concomitantly with other autoimmune diseases, though RP has been infrequently…”
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