Search Results - "SCHINKE, Thorsten"

Chemokines in Physiological and Pathological Bone Remodeling by Brylka, Laura J, Schinke, Thorsten

“…The bone matrix is constantly remodeled by bone-resorbing osteoclasts and bone-forming osteoblasts. These two cell types are fundamentally different in terms…”
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Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin by Albers, Joachim, Keller, Johannes, Baranowsky, Anke, Beil, Frank Timo, Catala-Lehnen, Philip, Schulze, Jochen, Amling, Michael, Schinke, Thorsten

“…Although Wnt signaling is considered a key regulatory pathway for bone formation, inactivation of β-catenin in osteoblasts does not affect their activity but…”
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Piezo1 Inactivation in Chondrocytes Impairs Trabecular Bone Formation by Hendrickx, Gretl, Fischer, Verena, Liedert, Astrid, Kroge, Simon, Haffner‐Luntzer, Melanie, Brylka, Laura, Pawlus, Eva, Schweizer, Michaela, Yorgan, Timur, Baranowsky, Anke, Rolvien, Tim, Neven, Mona, Schumacher, Udo, Beech, David J, Amling, Michael, Ignatius, Anita, Schinke, Thorsten

“…ABSTRACT The skeleton is a dynamic tissue continuously adapting to mechanical stimuli. Although matrix‐embedded osteocytes are considered as the key…”
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Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth by Dzamukova, Maria, Brunner, Tobias M., Miotla-Zarebska, Jadwiga, Heinrich, Frederik, Brylka, Laura, Mashreghi, Mir-Farzin, Kusumbe, Anjali, Kühn, Ralf, Schinke, Thorsten, Vincent, Tonia L., Löhning, Max

“…Bone growth requires a specialised, highly angiogenic blood vessel subtype, so-called type H vessels, which pave the way for osteoblasts surrounding these…”
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Chronic skin inflammation leads to bone loss by IL-17-mediated inhibition of Wnt signaling in osteoblasts by Uluçkan, Özge, Jimenez, Maria, Karbach, Susanne, Jeschke, Anke, Graña, Osvaldo, Keller, Johannes, Busse, Björn, Croxford, Andrew L, Finzel, Stephanie, Koenders, Marije, van den Berg, Wim, Schinke, Thorsten, Amling, Michael, Waisman, Ari, Schett, Georg, Wagner, Erwin F

“…Inflammation has important roles in tissue regeneration, autoimmunity, and cancer. Different inflammatory stimuli can lead to bone loss by mechanisms that are…”
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The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors by Benisch, Peggy, Schilling, Tatjana, Klein-Hitpass, Ludger, Frey, Sönke P, Seefried, Lothar, Raaijmakers, Nadja, Krug, Melanie, Regensburger, Martina, Zeck, Sabine, Schinke, Thorsten, Amling, Michael, Ebert, Regina, Jakob, Franz

“…Primary osteoporosis is an age-related disease characterized by an imbalance in bone homeostasis. While the resorptive aspect of the disease has been studied…”
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The chaperone activity of 4PBA ameliorates the skeletal phenotype of Chihuahua, a zebrafish model for dominant osteogenesis imperfecta by Gioia, Roberta, Tonelli, Francesca, Ceppi, Ilaria, Biggiogera, Marco, Leikin, Sergey, Fisher, Shannon, Tenedini, Elena, Yorgan, Timur A, Schinke, Thorsten, Tian, Kun, Schwartz, Jean-Marc, Forte, Fabiana, Wagener, Raimund, Villani, Simona, Rossi, Antonio, Forlino, Antonella

“…Classical osteogenesis imperfecta (OI) is a bone disease caused by type I collagen mutations and characterized by bone fragility, frequent fractures in absence…”
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Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling by Yorgan, Timur A., Peters, Stephanie, Amling, Michael, Schinke, Thorsten

“…Since cost-effective osteoanabolic treatment options remain to be established, it is relevant to identify specific molecules physiologically regulating…”
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Osteoblast-specific inactivation of p53 results in locally increased bone formation by Liao, Nannan, Koehne, Till, Tuckermann, Jan, Triviai, Ioanna, Amling, Michael, David, Jean-Pierre, Schinke, Thorsten, Luther, Julia

“…Inactivation of the tumor suppressor p53 (encoded by the Trp53 gene) is relevant for development and growth of different cancers, including osteosarcoma, a…”
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Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate by Trabszo, Christof, Ramms, Bastian, Chopra, Pradeep, Lüllmann-Rauch, Renate, Stroobants, Stijn, Sproß, Jens, Jeschke, Anke, Schinke, Thorsten, Boons, Geert-Jan, Esko, Jeffrey D, Lübke, Torben, Dierks, Thomas

“…Mucopolysaccharidoses comprise a group of rare metabolic diseases, in which the lysosomal degradation of glycosaminoglycans (GAGs) is impaired due to…”
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Deficiency of sphingosine-1-phosphate receptor 3 does not affect the skeletal phenotype of mice lacking sphingosine-1-phosphate lyase by Heckt, Timo, Brylka, Laura J, Neven, Mona, Amling, Michael, Schinke, Thorsten

“…Albeit osteoporosis is one of the most prevalent disorders in the aged population, treatment options stimulating the activity of bone-forming osteoblasts are…”
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Mechanical-induced bone remodeling does not depend on Piezo1 in dentoalveolar hard tissue by Nottmeier, Cita, Lavicky, Josef, Gonzalez Lopez, Marcos, Knauth, Sarah, Kahl-Nieke, Bärbel, Amling, Michael, Schinke, Thorsten, Helms, Jill, Krivanek, Jan, Koehne, Till, Petersen, Julian

“…Mechanosensory ion channels are proteins that are sensitive to mechanical forces. They are found in tissues throughout the body and play an important role in…”
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The serum protein α2–Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification by Schäfer, Cora, Heiss, Alexander, Schwarz, Anke, Westenfeld, Ralf, Ketteler, Markus, Floege, Jürgen, Müller-Esterl, Werner, Schinke, Thorsten, Jahnen-Dechent, Willi

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Genotype–Phenotype Associations in 72 Adults with Suspected ALPL-Associated Hypophosphatasia by Jandl, Nico Maximilian, Schmidt, Tobias, Rolvien, Tim, Stürznickel, Julian, Chrysostomou, Konstantin, von Vopelius, Emil, Volk, Alexander E., Schinke, Thorsten, Kubisch, Christian, Amling, Michael, Barvencik, Florian

“…Hypophosphatasia (HPP) is a rare inborn error of metabolism due to a decreased activity of tissue nonspecific alkaline phosphatase (TNSALP). As the onset and…”
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Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing by Bergdolt, Stephanie, Kovtun, Anna, Hägele, Yvonne, Liedert, Astrid, Schinke, Thorsten, Amling, Michael, Huber-Lang, Markus, Ignatius, Anita

“…The anaphylatoxin receptor C5aR1 plays an important role not only in innate immune responses, but also in bone metabolism and fracture healing, being highly…”
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Transgenic inhibition of interleukin-6 trans-signaling does not prevent skeletal pathologies in mucolipidosis type II mice by Westermann, Lena Marie, Baranowsky, Anke, Di Lorenzo, Giorgia, Danyukova, Tatyana, Soul, Jamie, Schwartz, Jean-Marc, Hendrickx, Gretl, Amling, Michael, Rose-John, Stefan, Garbers, Christoph, Schinke, Thorsten, Pohl, Sandra

“…Severe skeletal alterations are common symptoms in patients with mucolipidosis type II (MLII), a rare lysosomal storage disorder of childhood. We have…”
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Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production by Bozec, Aline, Bakiri, Latifa, Jimenez, Maria, Schinke, Thorsten, Amling, Michael, Wagner, Erwin F

“…The activator protein-1 (AP-1) transcription factor complex, in particular the Fos proteins, is an important regulator of bone homeostasis. Fra-2 (Fosl2), a…”
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Increased concentrations of conjugated bile acids are associated with osteoporosis in PSC patients by Stürznickel, Julian, Behler-Janbeck, Friederike, Baranowsky, Anke, Schmidt, Tobias, Schwinge, Dorothee, John, Clara, Lohse, Ansgar W., Schramm, Christoph, Heeren, Joerg, Schinke, Thorsten, Amling, Michael

“…Primary sclerosing cholangitis (PSC) is an idiopathic cholestatic liver disease characterized by chronic inflammation and progressive fibrosis of intra- and…”
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Tissue-specific mineralization defects in the periodontium of the Hyp mouse model of X-linked hypophosphatemia by Coyac, Benjamin R., Falgayrac, Guillaume, Baroukh, Brigitte, Slimani, Lotfi, Sadoine, Jérémy, Penel, Guillaume, Biosse-Duplan, Martin, Schinke, Thorsten, Linglart, Agnès, McKee, Marc D., Chaussain, Catherine, Bardet, Claire

“…X-linked hypophosphatemia (XLH) is a dento-osseous disorder caused by inactivating mutations in the PHEX gene, leading to renal phosphate wasting and…”
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Comparison of Bone Microarchitecture Between Adult Osteogenesis Imperfecta and Early-Onset Osteoporosis by Rolvien, Tim, Stürznickel, Julian, Schmidt, Felix N., Butscheidt, Sebastian, Schmidt, Tobias, Busse, Björn, Mundlos, Stefan, Schinke, Thorsten, Kornak, Uwe, Amling, Michael, Oheim, Ralf

“…Diagnosis and management of adult individuals with low bone mass and increased bone fragility before the age of 50 can be challenging. A number of these…”
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