Search Results - "SCHIMMER, Aaron"

Targeting nuclear import and export in hematological malignancies by Nachmias, Boaz, Schimmer, Aaron D.

“…The transport of proteins across the nuclear membrane is a highly regulated process, essential for the cell function. This transport is actively mediated by…”
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ZDHHC21: a mitochondrial vulnerability in AML by Schimmer, Aaron D.

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Mitochondrial ClpP serine protease-biological function and emerging target for cancer therapy by Nouri, Kazem, Feng, Yue, Schimmer, Aaron D.

“…Mitochondrial ClpP is a serine protease located in the mitochondrial matrix. This protease participates in mitochondrial protein quality control by degrading…”
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Contribution of metabolic abnormalities to acute myeloid leukemia pathogenesis by Egan, Grace, Schimmer, Aaron D.

“…Acute myeloid leukemia (AML) is a malignant disease of myeloid precursors. Somatic mutations have long been accepted as drivers of this malignancy. Over the…”
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E1 Enzymes as Therapeutic Targets in Cancer by Barghout, Samir H, Schimmer, Aaron D

“…Post-translational modifications of cellular substrates with ubiquitin and ubiquitin-like proteins (UBLs), including ubiquitin, SUMOs, and neural precursor…”
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What doesn’t kill you makes you stronger – bcl-2 promotes survival independent of proliferation by Schimmer, Aaron D.

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A 17-gene stemness score for rapid determination of risk in acute leukaemia by Ng, Stanley W. K., Mitchell, Amanda, Kennedy, James A., Chen, Weihsu C., McLeod, Jessica, Ibrahimova, Narmin, Arruda, Andrea, Popescu, Andreea, Gupta, Vikas, Schimmer, Aaron D., Schuh, Andre C., Yee, Karen W., Bullinger, Lars, Herold, Tobias, Görlich, Dennis, Büchner, Thomas, Hiddemann, Wolfgang, Berdel, Wolfgang E., Wörmann, Bernhard, Cheok, Meyling, Preudhomme, Claude, Dombret, Hervé, Metzeler, Klaus, Buske, Christian, Löwenberg, Bob, Valk, Peter J. M., Zandstra, Peter W., Minden, Mark D., Dick, John E., Wang, Jean C. Y.

“…A rapid gene signature test (LSC17) that captures stem cell expression programs in acute myeloid leukaemia patients at diagnosis is associated with therapy…”
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Anoikis resistance and tumor metastasis by Simpson, Craig D, Anyiwe, Kika, Schimmer, Aaron D

“…Abstract As a barrier to metastases, cells normally undergo apoptosis after they lose contact with their extra cellular matrix or their neighbouring cells…”
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Mitochondrial Shapeshifting Impacts AML Stemness and Differentiation by Schimmer, Aaron D.

“…In this issue of Cell Stem Cell, Pei et al. (2018) demonstrate that leukemic stem cells (LSCs) have enhanced mitochondrial fission, which is positively…”
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Venetoclax resistance in acute myeloid leukaemia—Clinical and biological insights by Nachmias, Boaz, Aumann, Shlomzion, Haran, Arnon, Schimmer, Aaron D.

“…Summary Venetoclax, an oral BCL‐2 inhibitor, has been widely incorporated in the treatment of acute myeloid leukaemia. The combination of hypomethylating…”
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Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia by Škrtić, Marko, Sriskanthadevan, Shrivani, Jhas, Bozhena, Gebbia, Marinella, Wang, Xiaoming, Wang, Zezhou, Hurren, Rose, Jitkova, Yulia, Gronda, Marcela, Maclean, Neil, Lai, Courteney K., Eberhard, Yanina, Bartoszko, Justyna, Spagnuolo, Paul, Rutledge, Angela C., Datti, Alessandro, Ketela, Troy, Moffat, Jason, Robinson, Brian H., Cameron, Jessie H., Wrana, Jeffery, Eaves, Connie J., Minden, Mark D., Wang, Jean C.Y., Dick, John E., Humphries, Keith, Nislow, Corey, Giaever, Guri, Schimmer, Aaron D.

“…To identify FDA-approved agents targeting leukemic cells, we performed a chemical screen on two human leukemic cell lines and identified the antimicrobial…”
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Inhibitor of apoptosis proteins: Translating basic knowledge into clinical practice by SCHIMMER, Aaron D

“…The inhibitor of apoptosis proteins (IAPs) are a family of antiapoptotic proteins that bind and inhibit caspases 3, 7, and/or 9, but not caspase 8. Growing…”
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Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality by Ishizawa, Jo, Zarabi, Sarah F., Davis, R. Eric, Halgas, Ondrej, Nii, Takenobu, Jitkova, Yulia, Zhao, Ran, St-Germain, Jonathan, Heese, Lauren E., Egan, Grace, Ruvolo, Vivian R., Barghout, Samir H., Nishida, Yuki, Hurren, Rose, Ma, Wencai, Gronda, Marcela, Link, Todd, Wong, Keith, Mabanglo, Mark, Kojima, Kensuke, Borthakur, Gautam, MacLean, Neil, Ma, Man Chun John, Leber, Andrew B., Minden, Mark D., Houry, Walid, Kantarjian, Hagop, Stogniew, Martin, Raught, Brian, Pai, Emil F., Schimmer, Aaron D., Andreeff, Michael

“…The mitochondrial caseinolytic protease P (ClpP) plays a central role in mitochondrial protein quality control by degrading misfolded proteins. Using genetic…”
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Novel Proteasome Inhibitors to Overcome Bortezomib Resistance by Ruschak, Amy M., Slassi, Malik, Kay, Lewis E., Schimmer, Aaron D.

“…The proteasome is an intracellular enzyme complex that degrades ubiquitin-tagged proteins and thereby regulates protein levels within the cell. Given this…”
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Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production by Lee, Jong Bok, Khan, Dilshad H., Hurren, Rose, Xu, Mingjing, Na, Yoosu, Kang, Hyeonjeong, Mirali, Sara, Wang, Xiaoming, Gronda, Marcela, Jitkova, Yulia, MacLean, Neil, Arruda, Andrea, Alaniz, Zoe, Konopleva, Marina Y., Andreeff, Michael, Minden, Mark D., Zhang, Li, Schimmer, Aaron D.

“…Venetoclax, a Bcl-2 inhibitor, in combination with the hypomethylating agent azacytidine, achieves complete remission with or without count recovery in ∼70% of…”
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Very long chain fatty acid metabolism is required in acute myeloid leukemia by Tcheng, Matthew, Roma, Alessia, Ahmed, Nawaz, Smith, Richard W., Jayanth, Preethi, Minden, Mark D., Schimmer, Aaron D., Hess, David A., Hope, Kristin, Rea, Kevin A., Akhtar, Tariq A., Bohrnsen, Eric, D'Alessandro, Angelo, Mohsen, Al-Walid, Vockley, Jerry, Spagnuolo, Paul A.

“…Acute myeloid leukemia (AML) cells have an atypical metabolic phenotype characterized by increased mitochondrial mass, as well as a greater reliance on…”
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Novel Mitochondrial Mechanisms of Cytarabine Resistance in Primary AML Cells by Schimmer, Aaron D

“…Farge and colleagues describe a novel approach to identify and study primary acute myeloid leukemia (AML) cells that persist in the marrow after chemotherapy…”
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Metabolic Flexibility in Leukemia—Adapt or Die by Nachmias, Boaz, Schimmer, Aaron D.

“…In this issue of Cancer Cell, Jones et al. demonstrate that LSCs are metabolically inflexible. LSCs rely on amino acid metabolism to fuel oxidative…”
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A multicenter phase I/II study of obatoclax mesylate administered as a 3- or 24-hour infusion in older patients with previously untreated acute myeloid leukemia by Schimmer, Aaron D, Raza, Azra, Carter, Thomas H, Claxton, David, Erba, Harry, DeAngelo, Daniel J, Tallman, Martin S, Goard, Carolyn, Borthakur, Gautam

“…An open-label phase I/II study of single-agent obatoclax determined a maximum tolerated dose (MTD) and schedule, safety, and efficacy in older patients (≥ 70…”
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Mitochondrial ATP-Dependent Proteases-Biological Function and Potential Anti-Cancer Targets by Feng, Yue, Nouri, Kazem, Schimmer, Aaron D

“…Cells must eliminate excess or damaged proteins to maintain protein homeostasis. To ensure protein homeostasis in the cytoplasm, cells rely on the…”
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