Search Results - "SCHIMMEL, Paul"

The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis by Schimmel, Paul

“…Key Points There is an incalculable number of potential molecular tRNA species, represented by their post-transcriptionally modified forms, by the presence of…”
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Mistranslation and its control by tRNA synthetases by Schimmel, Paul

“…Aminoacyl tRNA synthetases are ancient proteins that interpret the genetic material in all life forms. They are thought to have appeared during the transition…”
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New functions of aminoacyl-tRNA synthetases beyond translation by Schimmel, Paul, Guo, Min, Yang, Xiang-Lei

“…Aminoacyl tRNA synthetases (aaRSs) have progressively added domains and motifs that have no connection to aminoacylation. These additions equip aaRSs with new…”
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Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs by Kuhle, Bernhard, Chihade, Joseph, Schimmel, Paul

“…Metazoan complexity and life-style depend on the bioenergetic potential of mitochondria. However, higher aerobic activity and genetic drift impose strong…”
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Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration by Ishimura, Ryuta, Nagy, Gabor, Dotu, Ivan, Zhou, Huihao, Yang, Xiang-Lei, Schimmel, Paul, Senju, Satoru, Nishimura, Yasuharu, Chuang, Jeffrey H., Ackerman, Susan L.

“…In higher eukaryotes, transfer RNAs (tRNAs) with the same anticodon are encoded by multiple nuclear genes, and little is known about how mutations in these…”
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Aminoacyl tRNA synthetases and their connections to disease by Park, Sang Gyu, Schimmel, Paul, Kim, Sunghoon

“…Aminoacylation of transfer RNAs establishes the rules of the genetic code. The reactions are catalyzed by an ancient group of 20 enzymes (one for each amino…”
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ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase by Zhou, Huihao, Sun, Litao, Yang, Xiang-Lei, Schimmel, Paul

“…The crystal structure of prolyl tRNA synthetase simultaneously bound to its substrate ATP and its inhibitor halofuginone, a derivative of a compound used to…”
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Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA by Kuhle, Bernhard, Hirschi, Marscha, Doerfel, Lili K., Lander, Gabriel C., Schimmel, Paul

“…Human mitochondrial gene expression relies on the specific recognition and aminoacylation of mitochondrial tRNAs (mtRNAs) by nuclear-encoded mitochondrial…”
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Structural basis for a degenerate tRNA identity code and the evolution of bimodal specificity in human mitochondrial tRNA recognition by Kuhle, Bernhard, Hirschi, Marscha, Doerfel, Lili K., Lander, Gabriel C., Schimmel, Paul

“…Animal mitochondrial gene expression relies on specific interactions between nuclear-encoded aminoacyl-tRNA synthetases and mitochondria-encoded tRNAs. Their…”
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Functional expansion of human tRNA synthetases achieved by structural inventions by Guo, Min, Schimmel, Paul, Yang, Xiang-Lei

“…Known as an essential component of the translational apparatus, the aminoacyl-tRNA synthetase family catalyzes the first step reaction in protein synthesis,…”
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Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy by Liu, Ye, Satz, Jakob S., Vo, My-Nuong, Nangle, Leslie A., Schimmel, Paul, Ackerman, Susan L.

“…Misfolded proteins are an emerging hallmark of cardiac diseases. Although some misfolded proteins, such as desmin, are associated with mutations in the genes…”
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Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia by Kanaji, Taisuke, Vo, My-Nuong, Kanaji, Sachiko, Zarpellon, Alessandro, Shapiro, Ryan, Morodomi, Yosuke, Yuzuriha, Akinori, Eto, Koji, Belani, Rajesh, Do, Minh-Ha, Yang, Xiang-Lei, Ruggeri, Zaverio M., Schimmel, Paul

“…New mechanisms behind blood cell formation continue to be uncovered, with therapeutic approaches for hematological diseases being of great interest. Here we…”
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Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis by Park, Min Chul, Kang, Taehee, Jin, Da, Han, Jung Min, Kim, Sang Bum, Park, Yun Jung, Cho, Kiwon, Park, Young Woo, Guo, Min, He, Weiwei, Yang, Xiang-Lei, Schimmel, Paul, Kim, Sunghoon

“…Although adaptive systems of immunity against tumor initiation and destruction are well investigated, less understood is the role, if any, of endogenous…”
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Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid by Song, Youngzee, Zhou, Huihao, Vo, My-Nuong, Shi, Yi, Nawaz, Mir Hussain, Vargas-Rodriguez, Oscar, Diedrich, Jolene K., Yates, John R., Kishi, Shuji, Musier-Forsyth, Karin, Schimmel, Paul

“…Hundreds of non-proteinogenic (np) amino acids (AA) are found in plants and can in principle enter human protein synthesis through foods. While aminoacyl-tRNA…”
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Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration by Longo-Guess, Chantal M, Sundberg, John P, Davisson, Muriel T, Schimmel, Paul, Ackerman, Susan L, Lee, Jeong Woong, Beebe, Kirk, Jang, Jaeseon, Nangle, Leslie A, Cook, Susan A

“…Misfolded proteins are associated with several pathological conditions including neurodegeneration. Although some of these abnormally folded proteins result…”
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Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription by Ofir-Birin, Yifat, Fang, Pengfei, Bennett, Steven P., Zhang, Hui-Min, Wang, Jing, Rachmin, Inbal, Shapiro, Ryan, Song, Jing, Dagan, Arie, Pozo, Jorge, Kim, Sunghoon, Marshall, Alan G., Schimmel, Paul, Yang, Xiang-Lei, Nechushtan, Hovav, Razin, Ehud, Guo, Min

“…Lysyl-tRNA synthetase (LysRS), a component of the translation apparatus, is released from the cytoplasmic multi-tRNA synthetase complex (MSC) to activate the…”
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Sca-1 As a Marker of Stress-Induced Thrombopoiesis in Mice by Morodomi, Yosuke, Aiolfi, Roberto, Won, Eric, Kanaji, Sachiko, Schimmel, Paul, Ruggeri, Zaverio M., Kanaji, Taisuke

“…Introduction: It has been shown that megakaryocytes (MKs) can develop from a subset of MK-biased hematopoietic stem cells (HSCs). We also demonstrated that an…”
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An Active Dominant Mutation of Glycyl-tRNA Synthetase Causes Neuropathy in a Charcot-Marie-Tooth 2D Mouse Model by Seburn, Kevin L., Nangle, Leslie A., Cox, Gregory A., Schimmel, Paul, Burgess, Robert W.

“…Of the many inherited Charcot-Marie-Tooth peripheral neuropathies, type 2D (CMT2D) is caused by dominant point mutations in the gene GARS, encoding glycyl tRNA…”
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Distinct domains of tRNA synthetase recognize the same base pair by Schimmel, Paul, Mock, Marissa, Beebe, Kirk, Merriman, Eve

“…Synthesis of proteins containing errors (mistranslation) is prevented by aminoacyl transfer RNA synthetases through their accurate aminoacylation of cognate…”
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Chiral-Selective Aminoacylation of an RNA Minihelix: Mechanistic Features and Chiral Suppression by Tamura, Koji, Schimmel, Paul R.

“…Aminoacylation of RNA minihelices is speculated to be a key step in the transition from the putative RNA world to the theater of proteins. This reaction…”
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