Search Results - "SCHIENE, K"

Burrowing as a non-reflex behavioural readout for analgesic action in a rat model of sub-chronic knee joint inflammation by Rutten, K., Schiene, K., Robens, A., Leipelt, A., Pasqualon, T., Read, S.J., Christoph, T.

“…Background Innate responses against spontaneous pain are proposed to improve the predictive validity of preclinical analgesia models. Therefore, development…”
Get full text

Electrophysiological characterization of activation state-dependent Cav2 channel antagonist TROX-1 in spinal nerve injured rats by Patel, R., Rutten, K., Valdor, M., Schiene, K., Wigge, S., Schunk, S., Damann, N., Christoph, T., Dickenson, A.H.

“…•TROX-1 exhibits activation state-dependent inhibition of Cav2.2 in vitro.•TROX-1 selectively attenuates neuronal responses to mechanical…”
Get full text

Electrophysiological characterization of activation state-dependent Ca(v)2 channel antagonist TROX-1 in spinal nerve injured rats by Patel, R, Rutten, K, Valdor, M, Schiene, K, Wigge, S, Schunk, S, Damann, N, Christoph, T, Dickenson, A H

“…Prialt, a synthetic version of Ca(v)2.2 antagonist ω-conotoxin MVIIA derived from Conus magus, is the first clinically approved voltage-gated calcium channel…”
Get full text

Broad analgesic profile of buprenorphine in rodent models of acute and chronic pain by Christoph, Thomas, Kögel, Babette, Schiene, Klaus, Méen, Murielle, De Vry, Jean, Friderichs, Elmar

“…Buprenorphine is a potent opioid analgesic clinically used to treat moderate to severe pain. The present study assessed its analgesic efficacy in a broad range…”
Get full text

Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice by Christoph, Thomas, Bahrenberg, Gregor, De Vry, Jean, Englberger, Werner, Erdmann, Volker A., Frech, Moritz, Kögel, Babette, Röhl, Thomas, Schiene, Klaus, Schröder, Wolfgang, Seibler, Jost, Kurreck, Jens

“…The function of the transient receptor potential vanilloid 1 (TRPV1) cation channel was analyzed with RNA interference technologies and compared to TRPV1…”
Get full text

Functional Differentiation of Multiple Perilesional Zones After Focal Cerebral Ischemia by Witte, Otto W., Bidmon, Hans-J., Schiene, Klaus, Redecker, Christoph, Hagemann, Georg

“…Transient and permanent focal cerebral ischemia results in a series of typical pathophysiologic events. These consequences evolve in time and space and are not…”
Get full text

Antiallodynic effects of NMDA glycine(B) antagonists in neuropathic pain: possible peripheral mechanisms by Christoph, Thomas, Reissmüller, Elke, Schiene, Klaus, Englberger, Werner, Chizh, Boris A

“…NMDA receptors are implicated in central sensitisation underlying chronic pain, and NMDA antagonists have a potential for the treatment of neuropathic pain…”
Get full text

Widespread up-regulation of N-methyl- d-aspartate receptors after focal photothrombotic lesion in rat brain by Que, Meishu, Schiene, Klaus, Witte, Otto W, Zilles, Karl

“…Following focal brain lesions, complex adaptive processes take place in remote intact areas. The present study examines changes in NMDA ( N-methyl-…”
Get full text

Characterization of a small GTP-binding protein of the rab 5 family in Mesembryanthemum crystallinum with increased level of expression during early salt stress by Bolte, S, Schiene, K, Dietz, K J

“…A cDNA encoding a member of the Ypt/Rab family of small GTP-binding proteins was cloned from the facultative CAM plant Mesembryanthemum crystallinum. Mcrab5b…”
Get full text

Changes in GABA(A) and GABA(B) receptor binding following cortical photothrombosis: a quantitative receptor autoradiographic study by Que, M, Witte, O W, Neumann-Haefelin, T, Schiene, K, Schroeter, M, Zilles, K

“…Experimental cortical photothrombosis leads to pronounced alterations in the binding density of [3H]muscimol and [3H]baclofen to GABA(A) and GABA(B) receptors,…”
Get full text

Rab-related small GTP binding protein is predominantly expressed in root nodules of Medicago sativa by Schiene, K, Donath, S, Brecht, M, Puhler, A, Niehaus, K

“…Rab-related small GTP-binding proteins are known to be involved in the regulation of the vesicular transport system in eucaryotic cells. In this paper we…”
Get full text

Bihemispheric reduction of GABA A receptor binding following focal cortical photothrombotic lesions in the rat brain by Qü, Meishu, Buchkremer-Ratzmann, Irmgard, Schiene, Klaus, Schroeter, Michael, Witte, Otto W, Zilles, Karl

“…Focal brain lesions may lead to neuronal dysfunctions in remote (exofocal) brain regions. In the present study, focal lesions were induced in the hindlimb…”
Get full text

The use of surface plasmon resonance (SPR) and fluorescence resonance energy transfer (FRET) to monitor the interaction of the plant G-proteins Ms-Rac1 and Ms-Rac4 with GTP by Brecht, Martina, Sewald, Katherina, Schiene, Karin, Keen, Gunnar, Fricke, Matthias, Sauer, Markus, Niehaus, Karsten

“…Using an RT-PCR approach a cDNA clone, designated Ms-Rac4 and putatively coding for a small GTPase was isolated from Medicago sativa. Ms-Rac4 and the earlier…”
Get full text

Astroglial responses in photochemically induced focal ischemia of the rat cortex by SCHROETER, M, SCHIENE, K, KRAEMER, M, HAGEMANN, G, WEIGEL, H, EYSEL, U. T, WITTE, O. W, STOLL, G

“…This study investigated astroglial responses after focal cerebral ischemia in the rat cortex induced by photothrombosis. Astrocyte activation was studied at…”
Get full text

Lesion-induced network plasticity in remote brain areas by Witte, O W, Buchkremer-Ratzmann, I, Schiene, K, Neumann-Haefelin, T, Hagemann, G, Kraemer, M, Zilles, K, Freund, H J

Get full text

Characterization of VR1 within the BMBF‐Leitproject: ‘Molecular Pain Research’ by Jostock, R., Christoph, T., Schiene, K., Behrendt, H.‐J., Kurreck, J., Grünweller, A., Erdmann, V. A., Jahnel, R., Hucho, F., Gillen, C.

“…The vanilloid receptor VR1 is a ligand, heat and proton gated ion channel, expressed predominantly by primary sensory neurons. We show the molecular…”
Get full text

Nociceptin/orphanin FQ opioid peptide (NOP) receptor and µ-opioid peptide (MOP) receptors both contribute to the anti-hypersensitive effect of cebranopadol in a rat model of arthritic pain by Schiene, Klaus, Schröder, Wolfgang, Linz, Klaus, Frosch, Stefanie, Tzschentke, Thomas M., Jansen, Ulla, Christoph, Thomas

“…Cebranopadol is a novel, first-in-class analgesic with agonist activity at the nociceptin/orphanin FQ opioid peptide (NOP) receptor as well as the classical…”
Get full text

Changes in GABAA and GABAB receptor binding following cortical photothrombosis : A quantitative receptor autoradiographic study by QUE, M, WITTE, O. W, NEUMANN-HAEFELIN, T, SCHIENE, K, SCHROETER, M, ZILLES, K

Get full text

Enlargement of cortical vibrissa representation in the surround of an ischemic cortical lesion by Schiene, Klaus, Staiger, Jochen F, Bruehl, Claus, Witte, Otto W

“…It has been shown that cortical lesions are associated with an increase of excitability in surrounding brain regions, and with a downregulation of GABA A…”
Get full text

Investigation of TRPV1 loss-of-function phenotypes in TRPV1 Leu206Stop mice generated by N-ethyl-N-nitrosourea mutagenesis by Christoph, Thomas, Kögel, Babette, Schiene, Klaus, Peters, Thomas, Schröder, Wolfgang

“…N-ethyl-N-nitrosourea (ENU) random mutagenesis was used to generate a mouse model for the analysis of the transient receptor potential vanilloid 1 (TRPV1)…”
Get full text